Microscopic and radiographic analysis of the effect of particle size of demineralized bovine cancellous bone matrix on the repair of bone defects in femurs of rabbits

Detalhes bibliográficos
Autor(a) principal: Carneiro, Everdan
Data de Publicação: 2005
Outros Autores: Garcia, Roberto Brandão, Oliveira, Rodrigo Cardoso de, Moraes, Fernanda Gomes de, Menezes, Renato, Letra, Ariadne, Canova, Giovana Calichio, Cestari, Tania Mary, Granjeiro, José Mauro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/3268
Resumo: The bone tissue has a great regenerative potential, with ability to completely restore its structure and original functions. In some situations, though, bone defects cannot be self-repaired, thus requiring the use of grafts for a correct treatment and good prognosis. This work aimed at microscopically analyzing the effect of the particle size of demineralized bovine cancellous bone matrix in micro and macrogranular forms on the repair of bone defects in femurs of rabbits, with blood clot used as control. At 1, 3 and 6 months after implantation of the materials, the animals were killed and the anatomic specimens were removed. A foreign body-type granulomatous reaction containing macrophages and multinucleated giant cells in contact with the implanted particles was observed. These results suggest a failure in demineralization and/or interruption of the antigenic potential during production of the biomaterial. It is concluded that the size of the particles did not influence the evolution of the repair process of bone defects, acting only as bone-filler substances, and that the material implanted should be improved by quality control during production, since it may represent a good alternative for bone graft.
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spelling Microscopic and radiographic analysis of the effect of particle size of demineralized bovine cancellous bone matrix on the repair of bone defects in femurs of rabbits Análise microscópica e radiográfica do efeito do tamanho das partículas de matriz de osso medular bovino desmineralizado na reparação de defeito ósseo em fêmures de coelhos Enxerto xenogênicoOsso medular bovinoTamanho de partículaFêmurCoelhosXenogenic graftBovine cancellous boneParticle sizeFemurRabbit The bone tissue has a great regenerative potential, with ability to completely restore its structure and original functions. In some situations, though, bone defects cannot be self-repaired, thus requiring the use of grafts for a correct treatment and good prognosis. This work aimed at microscopically analyzing the effect of the particle size of demineralized bovine cancellous bone matrix in micro and macrogranular forms on the repair of bone defects in femurs of rabbits, with blood clot used as control. At 1, 3 and 6 months after implantation of the materials, the animals were killed and the anatomic specimens were removed. A foreign body-type granulomatous reaction containing macrophages and multinucleated giant cells in contact with the implanted particles was observed. These results suggest a failure in demineralization and/or interruption of the antigenic potential during production of the biomaterial. It is concluded that the size of the particles did not influence the evolution of the repair process of bone defects, acting only as bone-filler substances, and that the material implanted should be improved by quality control during production, since it may represent a good alternative for bone graft. O tecido ósseo possui grande potencial regenerativo com capacidade para restaurar completamente sua estrutura e função originais. Há situações em que os defeitos ósseos não conseguem por si só obter o reparo, casos em que se fazem necessários o uso de enxertos, para um correto tratamento e bom prognóstico. Este experimento teve o propósito de analisar microscopicamente o efeito do tamanho das partículas de matriz de osso medular bovino desmineralizado, nas formas micro e macrogranular, na reparação de defeito ósseo em fêmures de coelhos, tendo como controle o coágulo sanguíneo. Após 1,3 e 6 meses da implantação dos materiais, os animais foram mortos e as peças anatômicas removidas. Uma reação granulomatosa tipo corpo estranho, envolvendo as partículas implantadas, foi observada. Estes resultados sugerem falhas na desmineralização e/ou na retirada de potenciais antigênicos durante a produção do biomaterial. Podemos concluir que o tamanho das partículas não influenciou na evolução do processo reparativo dos defeitos ósseos, atuando apenas como substâncias osteopreenchedoras e que o material implantado deverá sofrer um aprimoramento no controle de qualidade na linha de produção, uma vez que poderá representar uma boa alternativa para enxertos ósseos. Universidade de São Paulo. Faculdade de Odontologia de Bauru2005-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/326810.1590/S1678-77572005000200012Journal of Applied Oral Science; Vol. 13 No. 2 (2005); 157-162 Journal of Applied Oral Science; Vol. 13 Núm. 2 (2005); 157-162 Journal of Applied Oral Science; v. 13 n. 2 (2005); 157-162 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3268/3958Copyright (c) 2005 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessCarneiro, EverdanGarcia, Roberto BrandãoOliveira, Rodrigo Cardoso deMoraes, Fernanda Gomes deMenezes, RenatoLetra, AriadneCanova, Giovana CalichioCestari, Tania MaryGranjeiro, José Mauro2012-04-27T11:50:19Zoai:revistas.usp.br:article/3268Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T11:50:19Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Microscopic and radiographic analysis of the effect of particle size of demineralized bovine cancellous bone matrix on the repair of bone defects in femurs of rabbits
Análise microscópica e radiográfica do efeito do tamanho das partículas de matriz de osso medular bovino desmineralizado na reparação de defeito ósseo em fêmures de coelhos
title Microscopic and radiographic analysis of the effect of particle size of demineralized bovine cancellous bone matrix on the repair of bone defects in femurs of rabbits
spellingShingle Microscopic and radiographic analysis of the effect of particle size of demineralized bovine cancellous bone matrix on the repair of bone defects in femurs of rabbits
Carneiro, Everdan
Enxerto xenogênico
Osso medular bovino
Tamanho de partícula
Fêmur
Coelhos
Xenogenic graft
Bovine cancellous bone
Particle size
Femur
Rabbit
title_short Microscopic and radiographic analysis of the effect of particle size of demineralized bovine cancellous bone matrix on the repair of bone defects in femurs of rabbits
title_full Microscopic and radiographic analysis of the effect of particle size of demineralized bovine cancellous bone matrix on the repair of bone defects in femurs of rabbits
title_fullStr Microscopic and radiographic analysis of the effect of particle size of demineralized bovine cancellous bone matrix on the repair of bone defects in femurs of rabbits
title_full_unstemmed Microscopic and radiographic analysis of the effect of particle size of demineralized bovine cancellous bone matrix on the repair of bone defects in femurs of rabbits
title_sort Microscopic and radiographic analysis of the effect of particle size of demineralized bovine cancellous bone matrix on the repair of bone defects in femurs of rabbits
author Carneiro, Everdan
author_facet Carneiro, Everdan
Garcia, Roberto Brandão
Oliveira, Rodrigo Cardoso de
Moraes, Fernanda Gomes de
Menezes, Renato
Letra, Ariadne
Canova, Giovana Calichio
Cestari, Tania Mary
Granjeiro, José Mauro
author_role author
author2 Garcia, Roberto Brandão
Oliveira, Rodrigo Cardoso de
Moraes, Fernanda Gomes de
Menezes, Renato
Letra, Ariadne
Canova, Giovana Calichio
Cestari, Tania Mary
Granjeiro, José Mauro
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carneiro, Everdan
Garcia, Roberto Brandão
Oliveira, Rodrigo Cardoso de
Moraes, Fernanda Gomes de
Menezes, Renato
Letra, Ariadne
Canova, Giovana Calichio
Cestari, Tania Mary
Granjeiro, José Mauro
dc.subject.por.fl_str_mv Enxerto xenogênico
Osso medular bovino
Tamanho de partícula
Fêmur
Coelhos
Xenogenic graft
Bovine cancellous bone
Particle size
Femur
Rabbit
topic Enxerto xenogênico
Osso medular bovino
Tamanho de partícula
Fêmur
Coelhos
Xenogenic graft
Bovine cancellous bone
Particle size
Femur
Rabbit
description The bone tissue has a great regenerative potential, with ability to completely restore its structure and original functions. In some situations, though, bone defects cannot be self-repaired, thus requiring the use of grafts for a correct treatment and good prognosis. This work aimed at microscopically analyzing the effect of the particle size of demineralized bovine cancellous bone matrix in micro and macrogranular forms on the repair of bone defects in femurs of rabbits, with blood clot used as control. At 1, 3 and 6 months after implantation of the materials, the animals were killed and the anatomic specimens were removed. A foreign body-type granulomatous reaction containing macrophages and multinucleated giant cells in contact with the implanted particles was observed. These results suggest a failure in demineralization and/or interruption of the antigenic potential during production of the biomaterial. It is concluded that the size of the particles did not influence the evolution of the repair process of bone defects, acting only as bone-filler substances, and that the material implanted should be improved by quality control during production, since it may represent a good alternative for bone graft.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3268
10.1590/S1678-77572005000200012
url https://www.revistas.usp.br/jaos/article/view/3268
identifier_str_mv 10.1590/S1678-77572005000200012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3268/3958
dc.rights.driver.fl_str_mv Copyright (c) 2005 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2005 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 13 No. 2 (2005); 157-162
Journal of Applied Oral Science; Vol. 13 Núm. 2 (2005); 157-162
Journal of Applied Oral Science; v. 13 n. 2 (2005); 157-162
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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