Importance of bacterial endotoxin (LPS) in endodontics

Detalhes bibliográficos
Autor(a) principal: Leonardo, Mario Roberto
Data de Publicação: 2004
Outros Autores: Silva, Raquel Assed Bezerra da, Assed, Sada, Nelson-Filho, Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/3184
Resumo: New knowledge of the structure and biological activity of endotoxins (LPS) has revolutionized concepts concerning their mechanisms of action and forms of inactivation. Since the 1980's, technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, predominate in root canals of teeth with pulp necrosis and radiographically visible chronic periapical lesions. Gram-negative bacteria not only have different factors of virulence and generate sub-products that are toxic to apical and periapical tissues, as also contain endotoxin (LPS) on their cell wall. This is especially important because endotoxin is released during multiplication or bacterial death, causing a series of biological effects that lead to an inflammatory reaction and resorption of mineralized tissues. Thus, due to the role of endotoxin in the pathogenesis of periapical lesions, we reviewed the literature concerning the biological activity of endotoxin and the relevance of its inactivation during treatment of teeth with pulp necrosis and chronic periapical lesion.
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spelling Importance of bacterial endotoxin (LPS) in endodontics A importância da endotoxina bacteriana (LPS) na endodontia atual Endotoxina bacterianaGram-negativosHidróxido de cálcioBacterial endotoxin (LPS)Gram-negative bacteriaCalcium hydroxide New knowledge of the structure and biological activity of endotoxins (LPS) has revolutionized concepts concerning their mechanisms of action and forms of inactivation. Since the 1980's, technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, predominate in root canals of teeth with pulp necrosis and radiographically visible chronic periapical lesions. Gram-negative bacteria not only have different factors of virulence and generate sub-products that are toxic to apical and periapical tissues, as also contain endotoxin (LPS) on their cell wall. This is especially important because endotoxin is released during multiplication or bacterial death, causing a series of biological effects that lead to an inflammatory reaction and resorption of mineralized tissues. Thus, due to the role of endotoxin in the pathogenesis of periapical lesions, we reviewed the literature concerning the biological activity of endotoxin and the relevance of its inactivation during treatment of teeth with pulp necrosis and chronic periapical lesion. O conhecimento mais aprofundado sobre a estrutura e atividade biológica das endotoxinas (LPS) revolucionou os conceitos sobre seu mecanismo de ação e formas de inativação. A partir da década de 80, os avanços tecnológicos na cultura e identificação microbiológica demonstraram que, em canais radiculares de dentes portadores de necrose pulpar e lesão periapical crônica, visível radiograficamente, predominam microrganismos anaeróbios, particularmente os gram-negativos. Como se sabe, os microrganismos gram-negativos, além de possuírem diferentes fatores de virulência e gerarem produtos e sub-produtos tóxicos aos tecidos apicais e periapicais, contêm endotoxina em sua parede celular. Esse conhecimento é particularmente importante, uma vez que a endotoxina é liberada durante a multiplicação ou morte bacteriana, exercendo uma série de efeitos biológicos relevantes, que conduzem a uma reação inflamatória e à reabsorção dos tecidos mineralizados. Tendo em vista o papel da endotoxina na patogênese das lesões periapicais, os autores realizaram uma revisão da literatura específica, abordando suas atividades biológicas e a importância de sua inativação durante o tratamento de dentes portadores de necrose pulpar e lesão periapical. Universidade de São Paulo. Faculdade de Odontologia de Bauru2004-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/318410.1590/S1678-77572004000200002Journal of Applied Oral Science; Vol. 12 No. 2 (2004); 93-98 Journal of Applied Oral Science; Vol. 12 Núm. 2 (2004); 93-98 Journal of Applied Oral Science; v. 12 n. 2 (2004); 93-98 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3184/3873Copyright (c) 2004 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessLeonardo, Mario RobertoSilva, Raquel Assed Bezerra daAssed, SadaNelson-Filho, Paulo2012-04-27T11:47:09Zoai:revistas.usp.br:article/3184Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T11:47:09Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Importance of bacterial endotoxin (LPS) in endodontics
A importância da endotoxina bacteriana (LPS) na endodontia atual
title Importance of bacterial endotoxin (LPS) in endodontics
spellingShingle Importance of bacterial endotoxin (LPS) in endodontics
Leonardo, Mario Roberto
Endotoxina bacteriana
Gram-negativos
Hidróxido de cálcio
Bacterial endotoxin (LPS)
Gram-negative bacteria
Calcium hydroxide
title_short Importance of bacterial endotoxin (LPS) in endodontics
title_full Importance of bacterial endotoxin (LPS) in endodontics
title_fullStr Importance of bacterial endotoxin (LPS) in endodontics
title_full_unstemmed Importance of bacterial endotoxin (LPS) in endodontics
title_sort Importance of bacterial endotoxin (LPS) in endodontics
author Leonardo, Mario Roberto
author_facet Leonardo, Mario Roberto
Silva, Raquel Assed Bezerra da
Assed, Sada
Nelson-Filho, Paulo
author_role author
author2 Silva, Raquel Assed Bezerra da
Assed, Sada
Nelson-Filho, Paulo
author2_role author
author
author
dc.contributor.author.fl_str_mv Leonardo, Mario Roberto
Silva, Raquel Assed Bezerra da
Assed, Sada
Nelson-Filho, Paulo
dc.subject.por.fl_str_mv Endotoxina bacteriana
Gram-negativos
Hidróxido de cálcio
Bacterial endotoxin (LPS)
Gram-negative bacteria
Calcium hydroxide
topic Endotoxina bacteriana
Gram-negativos
Hidróxido de cálcio
Bacterial endotoxin (LPS)
Gram-negative bacteria
Calcium hydroxide
description New knowledge of the structure and biological activity of endotoxins (LPS) has revolutionized concepts concerning their mechanisms of action and forms of inactivation. Since the 1980's, technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, predominate in root canals of teeth with pulp necrosis and radiographically visible chronic periapical lesions. Gram-negative bacteria not only have different factors of virulence and generate sub-products that are toxic to apical and periapical tissues, as also contain endotoxin (LPS) on their cell wall. This is especially important because endotoxin is released during multiplication or bacterial death, causing a series of biological effects that lead to an inflammatory reaction and resorption of mineralized tissues. Thus, due to the role of endotoxin in the pathogenesis of periapical lesions, we reviewed the literature concerning the biological activity of endotoxin and the relevance of its inactivation during treatment of teeth with pulp necrosis and chronic periapical lesion.
publishDate 2004
dc.date.none.fl_str_mv 2004-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3184
10.1590/S1678-77572004000200002
url https://www.revistas.usp.br/jaos/article/view/3184
identifier_str_mv 10.1590/S1678-77572004000200002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3184/3873
dc.rights.driver.fl_str_mv Copyright (c) 2004 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2004 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 12 No. 2 (2004); 93-98
Journal of Applied Oral Science; Vol. 12 Núm. 2 (2004); 93-98
Journal of Applied Oral Science; v. 12 n. 2 (2004); 93-98
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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