Importance of bacterial endotoxin (LPS) in endodontics
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/3184 |
Resumo: | New knowledge of the structure and biological activity of endotoxins (LPS) has revolutionized concepts concerning their mechanisms of action and forms of inactivation. Since the 1980's, technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, predominate in root canals of teeth with pulp necrosis and radiographically visible chronic periapical lesions. Gram-negative bacteria not only have different factors of virulence and generate sub-products that are toxic to apical and periapical tissues, as also contain endotoxin (LPS) on their cell wall. This is especially important because endotoxin is released during multiplication or bacterial death, causing a series of biological effects that lead to an inflammatory reaction and resorption of mineralized tissues. Thus, due to the role of endotoxin in the pathogenesis of periapical lesions, we reviewed the literature concerning the biological activity of endotoxin and the relevance of its inactivation during treatment of teeth with pulp necrosis and chronic periapical lesion. |
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Importance of bacterial endotoxin (LPS) in endodontics A importância da endotoxina bacteriana (LPS) na endodontia atual Endotoxina bacterianaGram-negativosHidróxido de cálcioBacterial endotoxin (LPS)Gram-negative bacteriaCalcium hydroxide New knowledge of the structure and biological activity of endotoxins (LPS) has revolutionized concepts concerning their mechanisms of action and forms of inactivation. Since the 1980's, technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, predominate in root canals of teeth with pulp necrosis and radiographically visible chronic periapical lesions. Gram-negative bacteria not only have different factors of virulence and generate sub-products that are toxic to apical and periapical tissues, as also contain endotoxin (LPS) on their cell wall. This is especially important because endotoxin is released during multiplication or bacterial death, causing a series of biological effects that lead to an inflammatory reaction and resorption of mineralized tissues. Thus, due to the role of endotoxin in the pathogenesis of periapical lesions, we reviewed the literature concerning the biological activity of endotoxin and the relevance of its inactivation during treatment of teeth with pulp necrosis and chronic periapical lesion. O conhecimento mais aprofundado sobre a estrutura e atividade biológica das endotoxinas (LPS) revolucionou os conceitos sobre seu mecanismo de ação e formas de inativação. A partir da década de 80, os avanços tecnológicos na cultura e identificação microbiológica demonstraram que, em canais radiculares de dentes portadores de necrose pulpar e lesão periapical crônica, visível radiograficamente, predominam microrganismos anaeróbios, particularmente os gram-negativos. Como se sabe, os microrganismos gram-negativos, além de possuírem diferentes fatores de virulência e gerarem produtos e sub-produtos tóxicos aos tecidos apicais e periapicais, contêm endotoxina em sua parede celular. Esse conhecimento é particularmente importante, uma vez que a endotoxina é liberada durante a multiplicação ou morte bacteriana, exercendo uma série de efeitos biológicos relevantes, que conduzem a uma reação inflamatória e à reabsorção dos tecidos mineralizados. Tendo em vista o papel da endotoxina na patogênese das lesões periapicais, os autores realizaram uma revisão da literatura específica, abordando suas atividades biológicas e a importância de sua inativação durante o tratamento de dentes portadores de necrose pulpar e lesão periapical. Universidade de São Paulo. Faculdade de Odontologia de Bauru2004-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/318410.1590/S1678-77572004000200002Journal of Applied Oral Science; Vol. 12 No. 2 (2004); 93-98 Journal of Applied Oral Science; Vol. 12 Núm. 2 (2004); 93-98 Journal of Applied Oral Science; v. 12 n. 2 (2004); 93-98 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3184/3873Copyright (c) 2004 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessLeonardo, Mario RobertoSilva, Raquel Assed Bezerra daAssed, SadaNelson-Filho, Paulo2012-04-27T11:47:09Zoai:revistas.usp.br:article/3184Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T11:47:09Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Importance of bacterial endotoxin (LPS) in endodontics A importância da endotoxina bacteriana (LPS) na endodontia atual |
title |
Importance of bacterial endotoxin (LPS) in endodontics |
spellingShingle |
Importance of bacterial endotoxin (LPS) in endodontics Leonardo, Mario Roberto Endotoxina bacteriana Gram-negativos Hidróxido de cálcio Bacterial endotoxin (LPS) Gram-negative bacteria Calcium hydroxide |
title_short |
Importance of bacterial endotoxin (LPS) in endodontics |
title_full |
Importance of bacterial endotoxin (LPS) in endodontics |
title_fullStr |
Importance of bacterial endotoxin (LPS) in endodontics |
title_full_unstemmed |
Importance of bacterial endotoxin (LPS) in endodontics |
title_sort |
Importance of bacterial endotoxin (LPS) in endodontics |
author |
Leonardo, Mario Roberto |
author_facet |
Leonardo, Mario Roberto Silva, Raquel Assed Bezerra da Assed, Sada Nelson-Filho, Paulo |
author_role |
author |
author2 |
Silva, Raquel Assed Bezerra da Assed, Sada Nelson-Filho, Paulo |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Leonardo, Mario Roberto Silva, Raquel Assed Bezerra da Assed, Sada Nelson-Filho, Paulo |
dc.subject.por.fl_str_mv |
Endotoxina bacteriana Gram-negativos Hidróxido de cálcio Bacterial endotoxin (LPS) Gram-negative bacteria Calcium hydroxide |
topic |
Endotoxina bacteriana Gram-negativos Hidróxido de cálcio Bacterial endotoxin (LPS) Gram-negative bacteria Calcium hydroxide |
description |
New knowledge of the structure and biological activity of endotoxins (LPS) has revolutionized concepts concerning their mechanisms of action and forms of inactivation. Since the 1980's, technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, predominate in root canals of teeth with pulp necrosis and radiographically visible chronic periapical lesions. Gram-negative bacteria not only have different factors of virulence and generate sub-products that are toxic to apical and periapical tissues, as also contain endotoxin (LPS) on their cell wall. This is especially important because endotoxin is released during multiplication or bacterial death, causing a series of biological effects that lead to an inflammatory reaction and resorption of mineralized tissues. Thus, due to the role of endotoxin in the pathogenesis of periapical lesions, we reviewed the literature concerning the biological activity of endotoxin and the relevance of its inactivation during treatment of teeth with pulp necrosis and chronic periapical lesion. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/3184 10.1590/S1678-77572004000200002 |
url |
https://www.revistas.usp.br/jaos/article/view/3184 |
identifier_str_mv |
10.1590/S1678-77572004000200002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/3184/3873 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2004 Journal of Applied Oral Science info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2004 Journal of Applied Oral Science |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 12 No. 2 (2004); 93-98 Journal of Applied Oral Science; Vol. 12 Núm. 2 (2004); 93-98 Journal of Applied Oral Science; v. 12 n. 2 (2004); 93-98 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221671339065344 |