Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study

Detalhes bibliográficos
Autor(a) principal: Freitas, Nicole Rosa de
Data de Publicação: 2022
Outros Autores: Guerrini, Luísa Belluco, Esper, Luis Augusto, Sbrana, Michyele Cristhiane, Dalben, Gisele da Silva, Soares, Simone, Almeida, Ana Lúcia Pompéia Fraga de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/201150
Resumo: The repair of bone defects raises the interest of investigators in several health specialties. Grafting techniques with bone substitutes and laser therapies have been investigated to replace autogenous bone and accelerate the bone healing process. Objective: To evaluate the effect of photobiomodulation therapy (PBMT) associated with guided bone regeneration (GBR) in critical size defects. Material and Methods: The study was conducted on 80 male rats (Rattus norvegicus albinus, Wistar) submitted to surgical creation of a critical size defect on the calvaria, divided into eight study groups: group C (control - only blood clot); group M (collagen membrane); group PBMT (photobiomodulation therapy); group AB (autogenous bone); group AB+PBMT; group AB+M; group PBMT+M; group AB+PBMT+M. The animals were killed 30 days postoperatively. After tissue processing, bone regeneration was evaluated by histomorphometric analysis and statistical analyses were performed (Tukey test, p<0.05). Results: All groups had greater area of newly formed bone compared to group C (9.96±4.49%). The group PBMT+M (achieved the greater quantity of new bone (64.09±7.62%), followed by groups PBMT (47.67±8.66%), M (47.43±15.73%), AB+PBMT (39.15±16.72%) and AB+PBMT+M (35.82±7.68%). After group C, the groups AB (25.10±16.59%) and AB+M (22.72±13.83%) had the smallest quantities of newly formed bone. The area of remaining particles did not have statistically significant difference between groups AB+M (14.93±8.92%) and AB+PBMT+M (14.76±6.58%). Conclusion: The PBMT utilization may be effective for bone repair, when associated with bone regeneration techniques.
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spelling Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo studyAutograftBone regenerationLasersThe repair of bone defects raises the interest of investigators in several health specialties. Grafting techniques with bone substitutes and laser therapies have been investigated to replace autogenous bone and accelerate the bone healing process. Objective: To evaluate the effect of photobiomodulation therapy (PBMT) associated with guided bone regeneration (GBR) in critical size defects. Material and Methods: The study was conducted on 80 male rats (Rattus norvegicus albinus, Wistar) submitted to surgical creation of a critical size defect on the calvaria, divided into eight study groups: group C (control - only blood clot); group M (collagen membrane); group PBMT (photobiomodulation therapy); group AB (autogenous bone); group AB+PBMT; group AB+M; group PBMT+M; group AB+PBMT+M. The animals were killed 30 days postoperatively. After tissue processing, bone regeneration was evaluated by histomorphometric analysis and statistical analyses were performed (Tukey test, p<0.05). Results: All groups had greater area of newly formed bone compared to group C (9.96±4.49%). The group PBMT+M (achieved the greater quantity of new bone (64.09±7.62%), followed by groups PBMT (47.67±8.66%), M (47.43±15.73%), AB+PBMT (39.15±16.72%) and AB+PBMT+M (35.82±7.68%). After group C, the groups AB (25.10±16.59%) and AB+M (22.72±13.83%) had the smallest quantities of newly formed bone. The area of remaining particles did not have statistically significant difference between groups AB+M (14.93±8.92%) and AB+PBMT+M (14.76±6.58%). Conclusion: The PBMT utilization may be effective for bone repair, when associated with bone regeneration techniques.Universidade de São Paulo. Faculdade de Odontologia de Bauru2022-08-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/201150Journal of Applied Oral Science; Vol. 26 (2018); e20170244Journal of Applied Oral Science; Vol. 26 (2018); e20170244Journal of Applied Oral Science; v. 26 (2018); e201702441678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/201150/185293Copyright (c) 2022 Journal of Applied Oral Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFreitas, Nicole Rosa deGuerrini, Luísa BellucoEsper, Luis AugustoSbrana, Michyele CristhianeDalben, Gisele da SilvaSoares, SimoneAlmeida, Ana Lúcia Pompéia Fraga de2022-08-17T18:31:08Zoai:revistas.usp.br:article/201150Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2022-08-17T18:31:08Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study
title Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study
spellingShingle Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study
Freitas, Nicole Rosa de
Autograft
Bone regeneration
Lasers
title_short Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study
title_full Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study
title_fullStr Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study
title_full_unstemmed Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study
title_sort Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study
author Freitas, Nicole Rosa de
author_facet Freitas, Nicole Rosa de
Guerrini, Luísa Belluco
Esper, Luis Augusto
Sbrana, Michyele Cristhiane
Dalben, Gisele da Silva
Soares, Simone
Almeida, Ana Lúcia Pompéia Fraga de
author_role author
author2 Guerrini, Luísa Belluco
Esper, Luis Augusto
Sbrana, Michyele Cristhiane
Dalben, Gisele da Silva
Soares, Simone
Almeida, Ana Lúcia Pompéia Fraga de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Freitas, Nicole Rosa de
Guerrini, Luísa Belluco
Esper, Luis Augusto
Sbrana, Michyele Cristhiane
Dalben, Gisele da Silva
Soares, Simone
Almeida, Ana Lúcia Pompéia Fraga de
dc.subject.por.fl_str_mv Autograft
Bone regeneration
Lasers
topic Autograft
Bone regeneration
Lasers
description The repair of bone defects raises the interest of investigators in several health specialties. Grafting techniques with bone substitutes and laser therapies have been investigated to replace autogenous bone and accelerate the bone healing process. Objective: To evaluate the effect of photobiomodulation therapy (PBMT) associated with guided bone regeneration (GBR) in critical size defects. Material and Methods: The study was conducted on 80 male rats (Rattus norvegicus albinus, Wistar) submitted to surgical creation of a critical size defect on the calvaria, divided into eight study groups: group C (control - only blood clot); group M (collagen membrane); group PBMT (photobiomodulation therapy); group AB (autogenous bone); group AB+PBMT; group AB+M; group PBMT+M; group AB+PBMT+M. The animals were killed 30 days postoperatively. After tissue processing, bone regeneration was evaluated by histomorphometric analysis and statistical analyses were performed (Tukey test, p<0.05). Results: All groups had greater area of newly formed bone compared to group C (9.96±4.49%). The group PBMT+M (achieved the greater quantity of new bone (64.09±7.62%), followed by groups PBMT (47.67±8.66%), M (47.43±15.73%), AB+PBMT (39.15±16.72%) and AB+PBMT+M (35.82±7.68%). After group C, the groups AB (25.10±16.59%) and AB+M (22.72±13.83%) had the smallest quantities of newly formed bone. The area of remaining particles did not have statistically significant difference between groups AB+M (14.93±8.92%) and AB+PBMT+M (14.76±6.58%). Conclusion: The PBMT utilization may be effective for bone repair, when associated with bone regeneration techniques.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/201150
url https://www.revistas.usp.br/jaos/article/view/201150
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/201150/185293
dc.rights.driver.fl_str_mv Copyright (c) 2022 Journal of Applied Oral Science
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Journal of Applied Oral Science
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 26 (2018); e20170244
Journal of Applied Oral Science; Vol. 26 (2018); e20170244
Journal of Applied Oral Science; v. 26 (2018); e20170244
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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