Cellular proliferation markers in peripheral and central fibromas: a comparative study
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/80441 |
Resumo: | Objective: To perform a comparative study of the cellular proliferation in the peripheral and central fibromas. Material and Methods: Immunohistochemistry for PCNA and the AgNOR technique were performed in 9 cases of peripheral odontogenic fibroma (POF), in 4 cases of odontogenic fibroma (OdF), in 8 cases of peripheral ossifying fibroma (PEOF) and 7 cases of ossifying fibroma (OsF). The Kruskal-Wallis and Mann-Whitney tests were used for the statistical analyses. Results: Mesenchymal component of the central lesions presented a higher mean number of AgNOR per nucleus and PCNA index than did the peripheral lesions (P≤0.05). The mean number of AgNOR per nucleus in the epithelial component proved to be higher in the OdF than in the POF (P≤0.05). The mesenchymal and epithelial components presented similar mean numbers of AgNOR per nucleus and PCNA index in the OdF, as well as a similar mean number of AgNOR per nucleus in the POF. Conclusions: The mesenchymal component may well play a role in the differences between the biological behaviour of the central lesions as compared to the peripheral lesions. Moreover, considering that the epithelial and mesenchymal components in odontogenic fibromas presented a similar proliferation index, more research is warranted to understand the true role of the epithelial components, which are believed to be inactive in nature, as well as in the development and biological behaviour of these lesions. |
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Journal of applied oral science (Online) |
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Cellular proliferation markers in peripheral and central fibromas: a comparative study Objective: To perform a comparative study of the cellular proliferation in the peripheral and central fibromas. Material and Methods: Immunohistochemistry for PCNA and the AgNOR technique were performed in 9 cases of peripheral odontogenic fibroma (POF), in 4 cases of odontogenic fibroma (OdF), in 8 cases of peripheral ossifying fibroma (PEOF) and 7 cases of ossifying fibroma (OsF). The Kruskal-Wallis and Mann-Whitney tests were used for the statistical analyses. Results: Mesenchymal component of the central lesions presented a higher mean number of AgNOR per nucleus and PCNA index than did the peripheral lesions (P≤0.05). The mean number of AgNOR per nucleus in the epithelial component proved to be higher in the OdF than in the POF (P≤0.05). The mesenchymal and epithelial components presented similar mean numbers of AgNOR per nucleus and PCNA index in the OdF, as well as a similar mean number of AgNOR per nucleus in the POF. Conclusions: The mesenchymal component may well play a role in the differences between the biological behaviour of the central lesions as compared to the peripheral lesions. Moreover, considering that the epithelial and mesenchymal components in odontogenic fibromas presented a similar proliferation index, more research is warranted to understand the true role of the epithelial components, which are believed to be inactive in nature, as well as in the development and biological behaviour of these lesions. Universidade de São Paulo. Faculdade de Odontologia de Bauru2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/8044110.1590/1678-7757201302116Journal of Applied Oral Science; Vol. 21 No. 2 (2013); 106-111Journal of Applied Oral Science; Vol. 21 Núm. 2 (2013); 106-111Journal of Applied Oral Science; v. 21 n. 2 (2013); 106-1111678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/80441/84104Copyright (c) 2013 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessGarcia, Bruna Goncalves Caldeira, Patricia Carlos Johann, Aline Cristina Batista Rodrigues Sousa, Suzana Cantanhede Orsini Machado de Caliari, Marcelo Vidigal Carmo, Maria Auxiliadora Vieira do Mesquita, Ricardo Alves 2014-05-08T12:31:57Zoai:revistas.usp.br:article/80441Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2014-05-08T12:31:57Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Cellular proliferation markers in peripheral and central fibromas: a comparative study |
title |
Cellular proliferation markers in peripheral and central fibromas: a comparative study |
spellingShingle |
Cellular proliferation markers in peripheral and central fibromas: a comparative study Garcia, Bruna Goncalves |
title_short |
Cellular proliferation markers in peripheral and central fibromas: a comparative study |
title_full |
Cellular proliferation markers in peripheral and central fibromas: a comparative study |
title_fullStr |
Cellular proliferation markers in peripheral and central fibromas: a comparative study |
title_full_unstemmed |
Cellular proliferation markers in peripheral and central fibromas: a comparative study |
title_sort |
Cellular proliferation markers in peripheral and central fibromas: a comparative study |
author |
Garcia, Bruna Goncalves |
author_facet |
Garcia, Bruna Goncalves Caldeira, Patricia Carlos Johann, Aline Cristina Batista Rodrigues Sousa, Suzana Cantanhede Orsini Machado de Caliari, Marcelo Vidigal Carmo, Maria Auxiliadora Vieira do Mesquita, Ricardo Alves |
author_role |
author |
author2 |
Caldeira, Patricia Carlos Johann, Aline Cristina Batista Rodrigues Sousa, Suzana Cantanhede Orsini Machado de Caliari, Marcelo Vidigal Carmo, Maria Auxiliadora Vieira do Mesquita, Ricardo Alves |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Garcia, Bruna Goncalves Caldeira, Patricia Carlos Johann, Aline Cristina Batista Rodrigues Sousa, Suzana Cantanhede Orsini Machado de Caliari, Marcelo Vidigal Carmo, Maria Auxiliadora Vieira do Mesquita, Ricardo Alves |
description |
Objective: To perform a comparative study of the cellular proliferation in the peripheral and central fibromas. Material and Methods: Immunohistochemistry for PCNA and the AgNOR technique were performed in 9 cases of peripheral odontogenic fibroma (POF), in 4 cases of odontogenic fibroma (OdF), in 8 cases of peripheral ossifying fibroma (PEOF) and 7 cases of ossifying fibroma (OsF). The Kruskal-Wallis and Mann-Whitney tests were used for the statistical analyses. Results: Mesenchymal component of the central lesions presented a higher mean number of AgNOR per nucleus and PCNA index than did the peripheral lesions (P≤0.05). The mean number of AgNOR per nucleus in the epithelial component proved to be higher in the OdF than in the POF (P≤0.05). The mesenchymal and epithelial components presented similar mean numbers of AgNOR per nucleus and PCNA index in the OdF, as well as a similar mean number of AgNOR per nucleus in the POF. Conclusions: The mesenchymal component may well play a role in the differences between the biological behaviour of the central lesions as compared to the peripheral lesions. Moreover, considering that the epithelial and mesenchymal components in odontogenic fibromas presented a similar proliferation index, more research is warranted to understand the true role of the epithelial components, which are believed to be inactive in nature, as well as in the development and biological behaviour of these lesions. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/80441 10.1590/1678-7757201302116 |
url |
https://www.revistas.usp.br/jaos/article/view/80441 |
identifier_str_mv |
10.1590/1678-7757201302116 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/80441/84104 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2013 Journal of Applied Oral Science info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2013 Journal of Applied Oral Science |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 21 No. 2 (2013); 106-111 Journal of Applied Oral Science; Vol. 21 Núm. 2 (2013); 106-111 Journal of Applied Oral Science; v. 21 n. 2 (2013); 106-111 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221677562363904 |