Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma

Detalhes bibliográficos
Autor(a) principal: Pereira, Camila Santos
Data de Publicação: 2013
Outros Autores: Oliveira, Marcos Vinicius Macedo de, Barros, Lucas Oliveira, Bandeira, Gabriela Alencar, Santos, Sergio Henrique Sousa, Basile, John R., Guimaraes, Andre Luiz Sena, De Paula, Alfredo Mauricio Batista
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/80493
Resumo: OBJECTIVE: This study aimed to investigate the expression of the MSH2 DNA repair protein in head and neck squamous cell carcinoma (HNSCC) in order to analyze its association with clinicopathologic factors and overall survival of patients. MATERIAL AND METHODS: Clinical data and primary lesions of HNSSC were collected from 55 patients who underwent surgical resection with postoperative radiotherapy in Montes Claros, state of Minas Gerais, Brazil, between 2000 and 2008. Immunohistochemical reactions were performed to analyze MSH2 protein expression. RESULTS: Bivariate analysis showed no significant correlation or association between MSH2 expression and clinicopathologic parameters by Mann-Whitney and Kruskal-Wallis tests. Patients with locoregional metastatic disease (OR=4.949, p
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spelling Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma OBJECTIVE: This study aimed to investigate the expression of the MSH2 DNA repair protein in head and neck squamous cell carcinoma (HNSCC) in order to analyze its association with clinicopathologic factors and overall survival of patients. MATERIAL AND METHODS: Clinical data and primary lesions of HNSSC were collected from 55 patients who underwent surgical resection with postoperative radiotherapy in Montes Claros, state of Minas Gerais, Brazil, between 2000 and 2008. Immunohistochemical reactions were performed to analyze MSH2 protein expression. RESULTS: Bivariate analysis showed no significant correlation or association between MSH2 expression and clinicopathologic parameters by Mann-Whitney and Kruskal-Wallis tests. Patients with locoregional metastatic disease (OR=4.949, pUniversidade de São Paulo. Faculdade de Odontologia de Bauru2013-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/8049310.1590/1679-775720130206Journal of Applied Oral Science; Vol. 21 No. 5 (2013); 416-421 Journal of Applied Oral Science; Vol. 21 Núm. 5 (2013); 416-421 Journal of Applied Oral Science; v. 21 n. 5 (2013); 416-421 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/80493/84156Copyright (c) 2013 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessPereira, Camila Santos Oliveira, Marcos Vinicius Macedo de Barros, Lucas Oliveira Bandeira, Gabriela Alencar Santos, Sergio Henrique Sousa Basile, John R. Guimaraes, Andre Luiz Sena De Paula, Alfredo Mauricio Batista 2014-05-08T12:53:42Zoai:revistas.usp.br:article/80493Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2014-05-08T12:53:42Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma
title Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma
spellingShingle Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma
Pereira, Camila Santos
title_short Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma
title_full Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma
title_fullStr Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma
title_full_unstemmed Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma
title_sort Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma
author Pereira, Camila Santos
author_facet Pereira, Camila Santos
Oliveira, Marcos Vinicius Macedo de
Barros, Lucas Oliveira
Bandeira, Gabriela Alencar
Santos, Sergio Henrique Sousa
Basile, John R.
Guimaraes, Andre Luiz Sena
De Paula, Alfredo Mauricio Batista
author_role author
author2 Oliveira, Marcos Vinicius Macedo de
Barros, Lucas Oliveira
Bandeira, Gabriela Alencar
Santos, Sergio Henrique Sousa
Basile, John R.
Guimaraes, Andre Luiz Sena
De Paula, Alfredo Mauricio Batista
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Camila Santos
Oliveira, Marcos Vinicius Macedo de
Barros, Lucas Oliveira
Bandeira, Gabriela Alencar
Santos, Sergio Henrique Sousa
Basile, John R.
Guimaraes, Andre Luiz Sena
De Paula, Alfredo Mauricio Batista
description OBJECTIVE: This study aimed to investigate the expression of the MSH2 DNA repair protein in head and neck squamous cell carcinoma (HNSCC) in order to analyze its association with clinicopathologic factors and overall survival of patients. MATERIAL AND METHODS: Clinical data and primary lesions of HNSSC were collected from 55 patients who underwent surgical resection with postoperative radiotherapy in Montes Claros, state of Minas Gerais, Brazil, between 2000 and 2008. Immunohistochemical reactions were performed to analyze MSH2 protein expression. RESULTS: Bivariate analysis showed no significant correlation or association between MSH2 expression and clinicopathologic parameters by Mann-Whitney and Kruskal-Wallis tests. Patients with locoregional metastatic disease (OR=4.949, p
publishDate 2013
dc.date.none.fl_str_mv 2013-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/80493
10.1590/1679-775720130206
url https://www.revistas.usp.br/jaos/article/view/80493
identifier_str_mv 10.1590/1679-775720130206
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/80493/84156
dc.rights.driver.fl_str_mv Copyright (c) 2013 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2013 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 21 No. 5 (2013); 416-421
Journal of Applied Oral Science; Vol. 21 Núm. 5 (2013); 416-421
Journal of Applied Oral Science; v. 21 n. 5 (2013); 416-421
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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