Hydroxyapatite crystallinity does not affect the repair of critical size bone defects

Detalhes bibliográficos
Autor(a) principal: Conz, Marcio Baltazar
Data de Publicação: 2011
Outros Autores: Granjeiro, José Mauro, Soares, Gloria de Almeida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/3918
Resumo: OBJECTIVE: The physicochemical properties of hydroxyapatite (HA) granules were observed to affect the biological behavior of graft materials. The aim of this work was to analyze the tissue response of two HA granules with different crystallinity and Ca/P ratio in vivo. MATERIAL AND METHODS: The HA granules were produced in the Biomaterials Laboratory (COPPE/UFRJ). The testing materials were HA granules presenting a Ca/P molar ratio of 1.60 and 28% crystallinity (HA-1), and a Ca/P molar ratio of 1.67 and 70% crystallinity (HA-2). Both HAs were implanted into a critical-size calvaria rat defects. RESULTS: To note, in the control group, the bone defects were filled with blood clot only. Descriptive and histomorphometric analyses after 1, 3, and 6 months postoperatively showed mild inflammatory infiltrate, mainly comprising macrophage-like and multinucleated giant cells, and an increase in the volume density of the fibrous tissues (p
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spelling Hydroxyapatite crystallinity does not affect the repair of critical size bone defects HydroxyapatiteBone graftingRatsHistologyBiocompatibility testing OBJECTIVE: The physicochemical properties of hydroxyapatite (HA) granules were observed to affect the biological behavior of graft materials. The aim of this work was to analyze the tissue response of two HA granules with different crystallinity and Ca/P ratio in vivo. MATERIAL AND METHODS: The HA granules were produced in the Biomaterials Laboratory (COPPE/UFRJ). The testing materials were HA granules presenting a Ca/P molar ratio of 1.60 and 28% crystallinity (HA-1), and a Ca/P molar ratio of 1.67 and 70% crystallinity (HA-2). Both HAs were implanted into a critical-size calvaria rat defects. RESULTS: To note, in the control group, the bone defects were filled with blood clot only. Descriptive and histomorphometric analyses after 1, 3, and 6 months postoperatively showed mild inflammatory infiltrate, mainly comprising macrophage-like and multinucleated giant cells, and an increase in the volume density of the fibrous tissues (pUniversidade de São Paulo. Faculdade de Odontologia de Bauru2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/391810.1590/S1678-77572011005000007Journal of Applied Oral Science; Vol. 19 No. 4 (2011); 337-342 Journal of Applied Oral Science; Vol. 19 Núm. 4 (2011); 337-342 Journal of Applied Oral Science; v. 19 n. 4 (2011); 337-342 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3918/4608Copyright (c) 2011 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessConz, Marcio BaltazarGranjeiro, José MauroSoares, Gloria de Almeida2012-04-27T12:14:19Zoai:revistas.usp.br:article/3918Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T12:14:19Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Hydroxyapatite crystallinity does not affect the repair of critical size bone defects
title Hydroxyapatite crystallinity does not affect the repair of critical size bone defects
spellingShingle Hydroxyapatite crystallinity does not affect the repair of critical size bone defects
Conz, Marcio Baltazar
Hydroxyapatite
Bone grafting
Rats
Histology
Biocompatibility testing
title_short Hydroxyapatite crystallinity does not affect the repair of critical size bone defects
title_full Hydroxyapatite crystallinity does not affect the repair of critical size bone defects
title_fullStr Hydroxyapatite crystallinity does not affect the repair of critical size bone defects
title_full_unstemmed Hydroxyapatite crystallinity does not affect the repair of critical size bone defects
title_sort Hydroxyapatite crystallinity does not affect the repair of critical size bone defects
author Conz, Marcio Baltazar
author_facet Conz, Marcio Baltazar
Granjeiro, José Mauro
Soares, Gloria de Almeida
author_role author
author2 Granjeiro, José Mauro
Soares, Gloria de Almeida
author2_role author
author
dc.contributor.author.fl_str_mv Conz, Marcio Baltazar
Granjeiro, José Mauro
Soares, Gloria de Almeida
dc.subject.por.fl_str_mv Hydroxyapatite
Bone grafting
Rats
Histology
Biocompatibility testing
topic Hydroxyapatite
Bone grafting
Rats
Histology
Biocompatibility testing
description OBJECTIVE: The physicochemical properties of hydroxyapatite (HA) granules were observed to affect the biological behavior of graft materials. The aim of this work was to analyze the tissue response of two HA granules with different crystallinity and Ca/P ratio in vivo. MATERIAL AND METHODS: The HA granules were produced in the Biomaterials Laboratory (COPPE/UFRJ). The testing materials were HA granules presenting a Ca/P molar ratio of 1.60 and 28% crystallinity (HA-1), and a Ca/P molar ratio of 1.67 and 70% crystallinity (HA-2). Both HAs were implanted into a critical-size calvaria rat defects. RESULTS: To note, in the control group, the bone defects were filled with blood clot only. Descriptive and histomorphometric analyses after 1, 3, and 6 months postoperatively showed mild inflammatory infiltrate, mainly comprising macrophage-like and multinucleated giant cells, and an increase in the volume density of the fibrous tissues (p
publishDate 2011
dc.date.none.fl_str_mv 2011-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3918
10.1590/S1678-77572011005000007
url https://www.revistas.usp.br/jaos/article/view/3918
identifier_str_mv 10.1590/S1678-77572011005000007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3918/4608
dc.rights.driver.fl_str_mv Copyright (c) 2011 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2011 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 19 No. 4 (2011); 337-342
Journal of Applied Oral Science; Vol. 19 Núm. 4 (2011); 337-342
Journal of Applied Oral Science; v. 19 n. 4 (2011); 337-342
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
_version_ 1800221676270518272

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