Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation

Detalhes bibliográficos
Autor(a) principal: Repeke, Carlos Eduardo
Data de Publicação: 2012
Outros Autores: Cardoso, Cristina Ribeiro, Claudino, Marcela, Silveira, Elcia Maria, Trombone, Ana Paula Favaro, Campanelli, Ana Paula, Silva, João Santana, Martins Júnior, Walter, Garlet, Gustavo Pompermaier
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/3995
Resumo: Periodontitis comprises a group of multifactorial diseases in which periodontopathogens accumulate in dental plaque and trigger host chronic inflammatory and immune responses against periodontal structures, which are determinant to the disease outcome. Although unusual cases of non-inflammatory destructive periodontal disease (NIDPD) are described, their pathogenesis remains unknown. A unique NIDPD case was investigated by clinical, microbiological, immunological and genetic tools. The patient, a non-smoking dental surgeon with excessive oral hygiene practice, presented a generalized bone resorption and tooth mobility, but not gingival inflammation or occlusion problems. No hematological, immunological or endocrine alterations were found. No periodontopathogens (A. actinomycetemcomitans, P. gingivalis, F. nucleatum and T. denticola) or viruses (HCMV, EBV-1 and HSV-1) were detected, along with levels of IL-1β and TNF-a in GCF compatible with healthy tissues. Conversely ALP, ACP and RANKL GCF levels were similar to diseased periodontal sites. Genetic investigation demonstrated that the patient carried some SNPs, as well HLA-DR4 (*0404) and HLA-B27 alleles, considered risk factors for bone loss. Then, a less vigorous and diminished frequency of toothbrushing was recommended to the patient, resulting in the arrest of alveolar bone loss, associated with the return of ALP, ACP and RANKL in GCF to normality levels. In conclusion, the unusual case presented here is compatible with the previous description of NIDPD, and the results that a possible combination of excessive force and frequency of mechanical stimulation with a potentially bone loss prone genotype could result in the alveolar bone loss seen in NIDPD.
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spelling Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation Periodontal diseasesNon-inflammatory destructive periodontal Periodontitis comprises a group of multifactorial diseases in which periodontopathogens accumulate in dental plaque and trigger host chronic inflammatory and immune responses against periodontal structures, which are determinant to the disease outcome. Although unusual cases of non-inflammatory destructive periodontal disease (NIDPD) are described, their pathogenesis remains unknown. A unique NIDPD case was investigated by clinical, microbiological, immunological and genetic tools. The patient, a non-smoking dental surgeon with excessive oral hygiene practice, presented a generalized bone resorption and tooth mobility, but not gingival inflammation or occlusion problems. No hematological, immunological or endocrine alterations were found. No periodontopathogens (A. actinomycetemcomitans, P. gingivalis, F. nucleatum and T. denticola) or viruses (HCMV, EBV-1 and HSV-1) were detected, along with levels of IL-1β and TNF-a in GCF compatible with healthy tissues. Conversely ALP, ACP and RANKL GCF levels were similar to diseased periodontal sites. Genetic investigation demonstrated that the patient carried some SNPs, as well HLA-DR4 (*0404) and HLA-B27 alleles, considered risk factors for bone loss. Then, a less vigorous and diminished frequency of toothbrushing was recommended to the patient, resulting in the arrest of alveolar bone loss, associated with the return of ALP, ACP and RANKL in GCF to normality levels. In conclusion, the unusual case presented here is compatible with the previous description of NIDPD, and the results that a possible combination of excessive force and frequency of mechanical stimulation with a potentially bone loss prone genotype could result in the alveolar bone loss seen in NIDPD. Universidade de São Paulo. Faculdade de Odontologia de Bauru2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/399510.1590/S1678-77572012000100020Journal of Applied Oral Science; Vol. 20 No. 1 (2012); 113-121 Journal of Applied Oral Science; Vol. 20 Núm. 1 (2012); 113-121 Journal of Applied Oral Science; v. 20 n. 1 (2012); 113-121 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3995/4685Copyright (c) 2012 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessRepeke, Carlos EduardoCardoso, Cristina RibeiroClaudino, MarcelaSilveira, Elcia MariaTrombone, Ana Paula FavaroCampanelli, Ana PaulaSilva, João SantanaMartins Júnior, WalterGarlet, Gustavo Pompermaier2012-04-27T12:18:01Zoai:revistas.usp.br:article/3995Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T12:18:01Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation
title Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation
spellingShingle Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation
Repeke, Carlos Eduardo
Periodontal diseases
Non-inflammatory destructive periodontal
title_short Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation
title_full Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation
title_fullStr Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation
title_full_unstemmed Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation
title_sort Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation
author Repeke, Carlos Eduardo
author_facet Repeke, Carlos Eduardo
Cardoso, Cristina Ribeiro
Claudino, Marcela
Silveira, Elcia Maria
Trombone, Ana Paula Favaro
Campanelli, Ana Paula
Silva, João Santana
Martins Júnior, Walter
Garlet, Gustavo Pompermaier
author_role author
author2 Cardoso, Cristina Ribeiro
Claudino, Marcela
Silveira, Elcia Maria
Trombone, Ana Paula Favaro
Campanelli, Ana Paula
Silva, João Santana
Martins Júnior, Walter
Garlet, Gustavo Pompermaier
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Repeke, Carlos Eduardo
Cardoso, Cristina Ribeiro
Claudino, Marcela
Silveira, Elcia Maria
Trombone, Ana Paula Favaro
Campanelli, Ana Paula
Silva, João Santana
Martins Júnior, Walter
Garlet, Gustavo Pompermaier
dc.subject.por.fl_str_mv Periodontal diseases
Non-inflammatory destructive periodontal
topic Periodontal diseases
Non-inflammatory destructive periodontal
description Periodontitis comprises a group of multifactorial diseases in which periodontopathogens accumulate in dental plaque and trigger host chronic inflammatory and immune responses against periodontal structures, which are determinant to the disease outcome. Although unusual cases of non-inflammatory destructive periodontal disease (NIDPD) are described, their pathogenesis remains unknown. A unique NIDPD case was investigated by clinical, microbiological, immunological and genetic tools. The patient, a non-smoking dental surgeon with excessive oral hygiene practice, presented a generalized bone resorption and tooth mobility, but not gingival inflammation or occlusion problems. No hematological, immunological or endocrine alterations were found. No periodontopathogens (A. actinomycetemcomitans, P. gingivalis, F. nucleatum and T. denticola) or viruses (HCMV, EBV-1 and HSV-1) were detected, along with levels of IL-1β and TNF-a in GCF compatible with healthy tissues. Conversely ALP, ACP and RANKL GCF levels were similar to diseased periodontal sites. Genetic investigation demonstrated that the patient carried some SNPs, as well HLA-DR4 (*0404) and HLA-B27 alleles, considered risk factors for bone loss. Then, a less vigorous and diminished frequency of toothbrushing was recommended to the patient, resulting in the arrest of alveolar bone loss, associated with the return of ALP, ACP and RANKL in GCF to normality levels. In conclusion, the unusual case presented here is compatible with the previous description of NIDPD, and the results that a possible combination of excessive force and frequency of mechanical stimulation with a potentially bone loss prone genotype could result in the alveolar bone loss seen in NIDPD.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3995
10.1590/S1678-77572012000100020
url https://www.revistas.usp.br/jaos/article/view/3995
identifier_str_mv 10.1590/S1678-77572012000100020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3995/4685
dc.rights.driver.fl_str_mv Copyright (c) 2012 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2012 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 20 No. 1 (2012); 113-121
Journal of Applied Oral Science; Vol. 20 Núm. 1 (2012); 113-121
Journal of Applied Oral Science; v. 20 n. 1 (2012); 113-121
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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