Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/3995 |
Resumo: | Periodontitis comprises a group of multifactorial diseases in which periodontopathogens accumulate in dental plaque and trigger host chronic inflammatory and immune responses against periodontal structures, which are determinant to the disease outcome. Although unusual cases of non-inflammatory destructive periodontal disease (NIDPD) are described, their pathogenesis remains unknown. A unique NIDPD case was investigated by clinical, microbiological, immunological and genetic tools. The patient, a non-smoking dental surgeon with excessive oral hygiene practice, presented a generalized bone resorption and tooth mobility, but not gingival inflammation or occlusion problems. No hematological, immunological or endocrine alterations were found. No periodontopathogens (A. actinomycetemcomitans, P. gingivalis, F. nucleatum and T. denticola) or viruses (HCMV, EBV-1 and HSV-1) were detected, along with levels of IL-1β and TNF-a in GCF compatible with healthy tissues. Conversely ALP, ACP and RANKL GCF levels were similar to diseased periodontal sites. Genetic investigation demonstrated that the patient carried some SNPs, as well HLA-DR4 (*0404) and HLA-B27 alleles, considered risk factors for bone loss. Then, a less vigorous and diminished frequency of toothbrushing was recommended to the patient, resulting in the arrest of alveolar bone loss, associated with the return of ALP, ACP and RANKL in GCF to normality levels. In conclusion, the unusual case presented here is compatible with the previous description of NIDPD, and the results that a possible combination of excessive force and frequency of mechanical stimulation with a potentially bone loss prone genotype could result in the alveolar bone loss seen in NIDPD. |
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Journal of applied oral science (Online) |
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Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation Periodontal diseasesNon-inflammatory destructive periodontal Periodontitis comprises a group of multifactorial diseases in which periodontopathogens accumulate in dental plaque and trigger host chronic inflammatory and immune responses against periodontal structures, which are determinant to the disease outcome. Although unusual cases of non-inflammatory destructive periodontal disease (NIDPD) are described, their pathogenesis remains unknown. A unique NIDPD case was investigated by clinical, microbiological, immunological and genetic tools. The patient, a non-smoking dental surgeon with excessive oral hygiene practice, presented a generalized bone resorption and tooth mobility, but not gingival inflammation or occlusion problems. No hematological, immunological or endocrine alterations were found. No periodontopathogens (A. actinomycetemcomitans, P. gingivalis, F. nucleatum and T. denticola) or viruses (HCMV, EBV-1 and HSV-1) were detected, along with levels of IL-1β and TNF-a in GCF compatible with healthy tissues. Conversely ALP, ACP and RANKL GCF levels were similar to diseased periodontal sites. Genetic investigation demonstrated that the patient carried some SNPs, as well HLA-DR4 (*0404) and HLA-B27 alleles, considered risk factors for bone loss. Then, a less vigorous and diminished frequency of toothbrushing was recommended to the patient, resulting in the arrest of alveolar bone loss, associated with the return of ALP, ACP and RANKL in GCF to normality levels. In conclusion, the unusual case presented here is compatible with the previous description of NIDPD, and the results that a possible combination of excessive force and frequency of mechanical stimulation with a potentially bone loss prone genotype could result in the alveolar bone loss seen in NIDPD. Universidade de São Paulo. Faculdade de Odontologia de Bauru2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/399510.1590/S1678-77572012000100020Journal of Applied Oral Science; Vol. 20 No. 1 (2012); 113-121 Journal of Applied Oral Science; Vol. 20 Núm. 1 (2012); 113-121 Journal of Applied Oral Science; v. 20 n. 1 (2012); 113-121 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3995/4685Copyright (c) 2012 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessRepeke, Carlos EduardoCardoso, Cristina RibeiroClaudino, MarcelaSilveira, Elcia MariaTrombone, Ana Paula FavaroCampanelli, Ana PaulaSilva, João SantanaMartins Júnior, WalterGarlet, Gustavo Pompermaier2012-04-27T12:18:01Zoai:revistas.usp.br:article/3995Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T12:18:01Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation |
title |
Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation |
spellingShingle |
Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation Repeke, Carlos Eduardo Periodontal diseases Non-inflammatory destructive periodontal |
title_short |
Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation |
title_full |
Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation |
title_fullStr |
Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation |
title_full_unstemmed |
Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation |
title_sort |
Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation |
author |
Repeke, Carlos Eduardo |
author_facet |
Repeke, Carlos Eduardo Cardoso, Cristina Ribeiro Claudino, Marcela Silveira, Elcia Maria Trombone, Ana Paula Favaro Campanelli, Ana Paula Silva, João Santana Martins Júnior, Walter Garlet, Gustavo Pompermaier |
author_role |
author |
author2 |
Cardoso, Cristina Ribeiro Claudino, Marcela Silveira, Elcia Maria Trombone, Ana Paula Favaro Campanelli, Ana Paula Silva, João Santana Martins Júnior, Walter Garlet, Gustavo Pompermaier |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Repeke, Carlos Eduardo Cardoso, Cristina Ribeiro Claudino, Marcela Silveira, Elcia Maria Trombone, Ana Paula Favaro Campanelli, Ana Paula Silva, João Santana Martins Júnior, Walter Garlet, Gustavo Pompermaier |
dc.subject.por.fl_str_mv |
Periodontal diseases Non-inflammatory destructive periodontal |
topic |
Periodontal diseases Non-inflammatory destructive periodontal |
description |
Periodontitis comprises a group of multifactorial diseases in which periodontopathogens accumulate in dental plaque and trigger host chronic inflammatory and immune responses against periodontal structures, which are determinant to the disease outcome. Although unusual cases of non-inflammatory destructive periodontal disease (NIDPD) are described, their pathogenesis remains unknown. A unique NIDPD case was investigated by clinical, microbiological, immunological and genetic tools. The patient, a non-smoking dental surgeon with excessive oral hygiene practice, presented a generalized bone resorption and tooth mobility, but not gingival inflammation or occlusion problems. No hematological, immunological or endocrine alterations were found. No periodontopathogens (A. actinomycetemcomitans, P. gingivalis, F. nucleatum and T. denticola) or viruses (HCMV, EBV-1 and HSV-1) were detected, along with levels of IL-1β and TNF-a in GCF compatible with healthy tissues. Conversely ALP, ACP and RANKL GCF levels were similar to diseased periodontal sites. Genetic investigation demonstrated that the patient carried some SNPs, as well HLA-DR4 (*0404) and HLA-B27 alleles, considered risk factors for bone loss. Then, a less vigorous and diminished frequency of toothbrushing was recommended to the patient, resulting in the arrest of alveolar bone loss, associated with the return of ALP, ACP and RANKL in GCF to normality levels. In conclusion, the unusual case presented here is compatible with the previous description of NIDPD, and the results that a possible combination of excessive force and frequency of mechanical stimulation with a potentially bone loss prone genotype could result in the alveolar bone loss seen in NIDPD. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/3995 10.1590/S1678-77572012000100020 |
url |
https://www.revistas.usp.br/jaos/article/view/3995 |
identifier_str_mv |
10.1590/S1678-77572012000100020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/3995/4685 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2012 Journal of Applied Oral Science info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2012 Journal of Applied Oral Science |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 20 No. 1 (2012); 113-121 Journal of Applied Oral Science; Vol. 20 Núm. 1 (2012); 113-121 Journal of Applied Oral Science; v. 20 n. 1 (2012); 113-121 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221676942655488 |