Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp : a laser Doppler flowmetry study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/205862 |
Resumo: | Objective: This study aims to determine and compare the dental pulp and gingival blood flow in patients referred for oropharyngeal radiotherapy (RT) at three different time points: before the start, immediately after, and six months following the completion of RT. The aim is also to evaluate the dependence of the pulp and gingival blood flow on the radiation dose. Methodology: A prospective study included 10 patients referred for intensity-modulated RT (IMRT) in the oropharyngeal region, with at least one intact tooth surrounded by a healthy gingiva. The dose received by each selected tooth and adjacent gingiva was determined according to the map of treatment planning and computer systems. The blood flow measurements were performed using the laser Doppler flowmetry (LDF) method. Results: Comparing vascular flows at three different time points, the median blood flow in the dental pulp showed no statistically significant difference (p=0.325), contrary to gingiva (p=0.011). Immediately after RT completion, the gingival flow significantly increased compared to its starting point (p=0.012). The pulp flow correlated negatively with the radiation dose, whereas a strong correlation was noted 6 months following the RT completion. Conclusions: RT caused a significant acute gingival blood flow increase, followed by a long-term (over six months) tendency to return to the starting levels. The dental pulp blood flow is differently affected by higher radiation doses (over 50Gy) in comparison to lower doses (below 50Gy). During RT planning, considering the possibility of protecting the teeth localized near the Gross Tumor Volume as a sensitive organ is recommended. |
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USP-17 |
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Journal of applied oral science (Online) |
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Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp : a laser Doppler flowmetry studyBlood flowDental pulpGingivaRadiotherapyLaser Doppler flowmetryObjective: This study aims to determine and compare the dental pulp and gingival blood flow in patients referred for oropharyngeal radiotherapy (RT) at three different time points: before the start, immediately after, and six months following the completion of RT. The aim is also to evaluate the dependence of the pulp and gingival blood flow on the radiation dose. Methodology: A prospective study included 10 patients referred for intensity-modulated RT (IMRT) in the oropharyngeal region, with at least one intact tooth surrounded by a healthy gingiva. The dose received by each selected tooth and adjacent gingiva was determined according to the map of treatment planning and computer systems. The blood flow measurements were performed using the laser Doppler flowmetry (LDF) method. Results: Comparing vascular flows at three different time points, the median blood flow in the dental pulp showed no statistically significant difference (p=0.325), contrary to gingiva (p=0.011). Immediately after RT completion, the gingival flow significantly increased compared to its starting point (p=0.012). The pulp flow correlated negatively with the radiation dose, whereas a strong correlation was noted 6 months following the RT completion. Conclusions: RT caused a significant acute gingival blood flow increase, followed by a long-term (over six months) tendency to return to the starting levels. The dental pulp blood flow is differently affected by higher radiation doses (over 50Gy) in comparison to lower doses (below 50Gy). During RT planning, considering the possibility of protecting the teeth localized near the Gross Tumor Volume as a sensitive organ is recommended.Universidade de São Paulo. Faculdade de Odontologia de Bauru2022-12-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/20586210.1590/1678-7757-2022-0329 Journal of Applied Oral Science; Vol. 30 (2022); e20220329Journal of Applied Oral Science; Vol. 30 (2022); e20220329Journal of Applied Oral Science; v. 30 (2022); e202203291678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/205862/189353Copyright (c) 2022 Journal of Applied Oral Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAntic, SvetlanaMarkovic-Vasiljkovic, BiljanaDzeletovic, BojanJelovac, Drago B.Kuzmanovic-Pficer, Jovana2022-12-15T14:07:35Zoai:revistas.usp.br:article/205862Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2022-12-15T14:07:35Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp : a laser Doppler flowmetry study |
title |
Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp : a laser Doppler flowmetry study |
spellingShingle |
Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp : a laser Doppler flowmetry study Antic, Svetlana Blood flow Dental pulp Gingiva Radiotherapy Laser Doppler flowmetry |
title_short |
Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp : a laser Doppler flowmetry study |
title_full |
Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp : a laser Doppler flowmetry study |
title_fullStr |
Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp : a laser Doppler flowmetry study |
title_full_unstemmed |
Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp : a laser Doppler flowmetry study |
title_sort |
Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp : a laser Doppler flowmetry study |
author |
Antic, Svetlana |
author_facet |
Antic, Svetlana Markovic-Vasiljkovic, Biljana Dzeletovic, Bojan Jelovac, Drago B. Kuzmanovic-Pficer, Jovana |
author_role |
author |
author2 |
Markovic-Vasiljkovic, Biljana Dzeletovic, Bojan Jelovac, Drago B. Kuzmanovic-Pficer, Jovana |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Antic, Svetlana Markovic-Vasiljkovic, Biljana Dzeletovic, Bojan Jelovac, Drago B. Kuzmanovic-Pficer, Jovana |
dc.subject.por.fl_str_mv |
Blood flow Dental pulp Gingiva Radiotherapy Laser Doppler flowmetry |
topic |
Blood flow Dental pulp Gingiva Radiotherapy Laser Doppler flowmetry |
description |
Objective: This study aims to determine and compare the dental pulp and gingival blood flow in patients referred for oropharyngeal radiotherapy (RT) at three different time points: before the start, immediately after, and six months following the completion of RT. The aim is also to evaluate the dependence of the pulp and gingival blood flow on the radiation dose. Methodology: A prospective study included 10 patients referred for intensity-modulated RT (IMRT) in the oropharyngeal region, with at least one intact tooth surrounded by a healthy gingiva. The dose received by each selected tooth and adjacent gingiva was determined according to the map of treatment planning and computer systems. The blood flow measurements were performed using the laser Doppler flowmetry (LDF) method. Results: Comparing vascular flows at three different time points, the median blood flow in the dental pulp showed no statistically significant difference (p=0.325), contrary to gingiva (p=0.011). Immediately after RT completion, the gingival flow significantly increased compared to its starting point (p=0.012). The pulp flow correlated negatively with the radiation dose, whereas a strong correlation was noted 6 months following the RT completion. Conclusions: RT caused a significant acute gingival blood flow increase, followed by a long-term (over six months) tendency to return to the starting levels. The dental pulp blood flow is differently affected by higher radiation doses (over 50Gy) in comparison to lower doses (below 50Gy). During RT planning, considering the possibility of protecting the teeth localized near the Gross Tumor Volume as a sensitive organ is recommended. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/205862 10.1590/1678-7757-2022-0329 |
url |
https://www.revistas.usp.br/jaos/article/view/205862 |
identifier_str_mv |
10.1590/1678-7757-2022-0329 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/205862/189353 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 30 (2022); e20220329 Journal of Applied Oral Science; Vol. 30 (2022); e20220329 Journal of Applied Oral Science; v. 30 (2022); e20220329 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221683309608960 |