Drug delivery systems for oral disease applications
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/195768 |
Resumo: | There are many restrictions on topical medications for the oral cavity. Various factors affect the topical application of drugs in the oral cavity, an open and complex environment. The complex physical and chemical environment of the oral cavity, such as saliva and food, will influence the effect of free drugs. Therefore, drug delivery systems have served as supporting structures or as carriers loading active ingredients, such as antimicrobial agents and growth factors (GFs), to promote antibacterial properties, tissue regeneration, and engineering for drug diffusion. These drug delivery systems are considered in the prevention and treatment of dental caries, periodontal disease, periapical disease, the delivery of anesthetic drugs, etc. These carrier materials are designed in different ways for clinical application, including nanoparticles, hydrogels, nanofibers, films, and scaffolds. This review aimed to summarize the advantages and disadvantages of different carrier materials. We discuss synthesis methods and their application scope to provide new perspectives for the development and preparation of more favorable and effective local oral drug delivery systems. |
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Journal of applied oral science (Online) |
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Drug delivery systems for oral disease applicationsDelivery systemsDental cariesHydrogelsNanoparticlesPeriodontal diseaseThere are many restrictions on topical medications for the oral cavity. Various factors affect the topical application of drugs in the oral cavity, an open and complex environment. The complex physical and chemical environment of the oral cavity, such as saliva and food, will influence the effect of free drugs. Therefore, drug delivery systems have served as supporting structures or as carriers loading active ingredients, such as antimicrobial agents and growth factors (GFs), to promote antibacterial properties, tissue regeneration, and engineering for drug diffusion. These drug delivery systems are considered in the prevention and treatment of dental caries, periodontal disease, periapical disease, the delivery of anesthetic drugs, etc. These carrier materials are designed in different ways for clinical application, including nanoparticles, hydrogels, nanofibers, films, and scaffolds. This review aimed to summarize the advantages and disadvantages of different carrier materials. We discuss synthesis methods and their application scope to provide new perspectives for the development and preparation of more favorable and effective local oral drug delivery systems.Universidade de São Paulo. Faculdade de Odontologia de Bauru2022-03-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/19576810.1590/1678-7757-2021-0349Journal of Applied Oral Science; Vol. 30 (2022); e20210349Journal of Applied Oral Science; Vol. 30 (2022); e20210349Journal of Applied Oral Science; v. 30 (2022); e202103491678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/195768/180668Copyright (c) 2022 Journal of Applied Oral Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessZhang, Yue Jiang, Ruining Lei, Lei Yang, Yingming Hu, Tao 2022-03-18T12:11:07Zoai:revistas.usp.br:article/195768Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2022-03-18T12:11:07Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Drug delivery systems for oral disease applications |
title |
Drug delivery systems for oral disease applications |
spellingShingle |
Drug delivery systems for oral disease applications Zhang, Yue Delivery systems Dental caries Hydrogels Nanoparticles Periodontal disease |
title_short |
Drug delivery systems for oral disease applications |
title_full |
Drug delivery systems for oral disease applications |
title_fullStr |
Drug delivery systems for oral disease applications |
title_full_unstemmed |
Drug delivery systems for oral disease applications |
title_sort |
Drug delivery systems for oral disease applications |
author |
Zhang, Yue |
author_facet |
Zhang, Yue Jiang, Ruining Lei, Lei Yang, Yingming Hu, Tao |
author_role |
author |
author2 |
Jiang, Ruining Lei, Lei Yang, Yingming Hu, Tao |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Zhang, Yue Jiang, Ruining Lei, Lei Yang, Yingming Hu, Tao |
dc.subject.por.fl_str_mv |
Delivery systems Dental caries Hydrogels Nanoparticles Periodontal disease |
topic |
Delivery systems Dental caries Hydrogels Nanoparticles Periodontal disease |
description |
There are many restrictions on topical medications for the oral cavity. Various factors affect the topical application of drugs in the oral cavity, an open and complex environment. The complex physical and chemical environment of the oral cavity, such as saliva and food, will influence the effect of free drugs. Therefore, drug delivery systems have served as supporting structures or as carriers loading active ingredients, such as antimicrobial agents and growth factors (GFs), to promote antibacterial properties, tissue regeneration, and engineering for drug diffusion. These drug delivery systems are considered in the prevention and treatment of dental caries, periodontal disease, periapical disease, the delivery of anesthetic drugs, etc. These carrier materials are designed in different ways for clinical application, including nanoparticles, hydrogels, nanofibers, films, and scaffolds. This review aimed to summarize the advantages and disadvantages of different carrier materials. We discuss synthesis methods and their application scope to provide new perspectives for the development and preparation of more favorable and effective local oral drug delivery systems. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-18 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/195768 10.1590/1678-7757-2021-0349 |
url |
https://www.revistas.usp.br/jaos/article/view/195768 |
identifier_str_mv |
10.1590/1678-7757-2021-0349 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/195768/180668 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 30 (2022); e20210349 Journal of Applied Oral Science; Vol. 30 (2022); e20210349 Journal of Applied Oral Science; v. 30 (2022); e20210349 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221682558828544 |