Drug delivery systems for oral disease applications

Detalhes bibliográficos
Autor(a) principal: Zhang, Yue
Data de Publicação: 2022
Outros Autores: Jiang, Ruining, Lei, Lei, Yang, Yingming, Hu, Tao
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/195768
Resumo: There are many restrictions on topical medications for the oral cavity. Various factors affect the topical application of drugs in the oral cavity, an open and complex environment. The complex physical and chemical environment of the oral cavity, such as saliva and food, will influence the effect of free drugs. Therefore, drug delivery systems have served as supporting structures or as carriers loading active ingredients, such as antimicrobial agents and growth factors (GFs), to promote antibacterial properties, tissue regeneration, and engineering for drug diffusion. These drug delivery systems are considered in the prevention and treatment of dental caries, periodontal disease, periapical disease, the delivery of anesthetic drugs, etc. These carrier materials are designed in different ways for clinical application, including nanoparticles, hydrogels, nanofibers, films, and scaffolds. This review aimed to summarize the advantages and disadvantages of different carrier materials. We discuss synthesis methods and their application scope to provide new perspectives for the development and preparation of more favorable and effective local oral drug delivery systems.
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spelling Drug delivery systems for oral disease applicationsDelivery systemsDental cariesHydrogelsNanoparticlesPeriodontal diseaseThere are many restrictions on topical medications for the oral cavity. Various factors affect the topical application of drugs in the oral cavity, an open and complex environment. The complex physical and chemical environment of the oral cavity, such as saliva and food, will influence the effect of free drugs. Therefore, drug delivery systems have served as supporting structures or as carriers loading active ingredients, such as antimicrobial agents and growth factors (GFs), to promote antibacterial properties, tissue regeneration, and engineering for drug diffusion. These drug delivery systems are considered in the prevention and treatment of dental caries, periodontal disease, periapical disease, the delivery of anesthetic drugs, etc. These carrier materials are designed in different ways for clinical application, including nanoparticles, hydrogels, nanofibers, films, and scaffolds. This review aimed to summarize the advantages and disadvantages of different carrier materials. We discuss synthesis methods and their application scope to provide new perspectives for the development and preparation of more favorable and effective local oral drug delivery systems.Universidade de São Paulo. Faculdade de Odontologia de Bauru2022-03-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/19576810.1590/1678-7757-2021-0349Journal of Applied Oral Science; Vol. 30 (2022); e20210349Journal of Applied Oral Science; Vol. 30 (2022); e20210349Journal of Applied Oral Science; v. 30 (2022); e202103491678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/195768/180668Copyright (c) 2022 Journal of Applied Oral Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessZhang, Yue Jiang, Ruining Lei, Lei Yang, Yingming Hu, Tao 2022-03-18T12:11:07Zoai:revistas.usp.br:article/195768Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2022-03-18T12:11:07Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Drug delivery systems for oral disease applications
title Drug delivery systems for oral disease applications
spellingShingle Drug delivery systems for oral disease applications
Zhang, Yue
Delivery systems
Dental caries
Hydrogels
Nanoparticles
Periodontal disease
title_short Drug delivery systems for oral disease applications
title_full Drug delivery systems for oral disease applications
title_fullStr Drug delivery systems for oral disease applications
title_full_unstemmed Drug delivery systems for oral disease applications
title_sort Drug delivery systems for oral disease applications
author Zhang, Yue
author_facet Zhang, Yue
Jiang, Ruining
Lei, Lei
Yang, Yingming
Hu, Tao
author_role author
author2 Jiang, Ruining
Lei, Lei
Yang, Yingming
Hu, Tao
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Zhang, Yue
Jiang, Ruining
Lei, Lei
Yang, Yingming
Hu, Tao
dc.subject.por.fl_str_mv Delivery systems
Dental caries
Hydrogels
Nanoparticles
Periodontal disease
topic Delivery systems
Dental caries
Hydrogels
Nanoparticles
Periodontal disease
description There are many restrictions on topical medications for the oral cavity. Various factors affect the topical application of drugs in the oral cavity, an open and complex environment. The complex physical and chemical environment of the oral cavity, such as saliva and food, will influence the effect of free drugs. Therefore, drug delivery systems have served as supporting structures or as carriers loading active ingredients, such as antimicrobial agents and growth factors (GFs), to promote antibacterial properties, tissue regeneration, and engineering for drug diffusion. These drug delivery systems are considered in the prevention and treatment of dental caries, periodontal disease, periapical disease, the delivery of anesthetic drugs, etc. These carrier materials are designed in different ways for clinical application, including nanoparticles, hydrogels, nanofibers, films, and scaffolds. This review aimed to summarize the advantages and disadvantages of different carrier materials. We discuss synthesis methods and their application scope to provide new perspectives for the development and preparation of more favorable and effective local oral drug delivery systems.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-18
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/195768
10.1590/1678-7757-2021-0349
url https://www.revistas.usp.br/jaos/article/view/195768
identifier_str_mv 10.1590/1678-7757-2021-0349
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/195768/180668
dc.rights.driver.fl_str_mv Copyright (c) 2022 Journal of Applied Oral Science
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Journal of Applied Oral Science
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 30 (2022); e20210349
Journal of Applied Oral Science; Vol. 30 (2022); e20210349
Journal of Applied Oral Science; v. 30 (2022); e20210349
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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