Development of periradicular lesions in normal and diabetic rats

Detalhes bibliográficos
Autor(a) principal: Armada-Dias, Luci
Data de Publicação: 2006
Outros Autores: Breda, Jorge, Provenzano, José Claudio, Breitenbach, Marisa, Rôças, Isabela das Neves, Gahyva, Sérgio Márcio Motta, Siqueira Junior, José Freitas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/3402
Resumo: Evidence suggests that diabetic patients are more significantly affected by problems of endodontic origin. This study sought to radiographically and histologically examine the development of periradicular inflammation in control and in diabetic rats after induction of pulpal infection. The pulps of the mandibular first molars of normal and streptozotocin-induced diabetic rats were exposed and left in contact with their oral cavities for 21 and 40 days. Afterwards, the animals were sacrificed, the mandibles were surgically removed, fixed in formalin and then radiographed in a standardized position. The radiographic images of the periradicular lesions were scanned and computerized images were evaluated for the total area of the lesions using a specific software. Representative specimens were also prepared for histopathological analysis. Radiographic analysis revealed that diabetic rats presented significantly larger periradicular lesions when compared with control rats, regardless of the experimental period (p
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spelling Development of periradicular lesions in normal and diabetic rats Desenvolvimento de lesões perirradiculares em ratos normais e diabéticos Infecção endodônticaPeriodontite apicalDiabetesEndodontic infectionApical periodontitisDiabetes Evidence suggests that diabetic patients are more significantly affected by problems of endodontic origin. This study sought to radiographically and histologically examine the development of periradicular inflammation in control and in diabetic rats after induction of pulpal infection. The pulps of the mandibular first molars of normal and streptozotocin-induced diabetic rats were exposed and left in contact with their oral cavities for 21 and 40 days. Afterwards, the animals were sacrificed, the mandibles were surgically removed, fixed in formalin and then radiographed in a standardized position. The radiographic images of the periradicular lesions were scanned and computerized images were evaluated for the total area of the lesions using a specific software. Representative specimens were also prepared for histopathological analysis. Radiographic analysis revealed that diabetic rats presented significantly larger periradicular lesions when compared with control rats, regardless of the experimental period (p Evidências indicam que pacientes diabéticos são mais significativamente afetados por problemas de origem endodôntica. Este estudo avaliou radiográfica e histologicamente o desenvolvimento de inflamação perirradicular em ratos controle e diabéticos depois da indução de infecção pulpar. As polpas dos primeiros molares inferiores de ratos normais ou diabéticos foram expostas e deixadas em contato com a cavidade oral por 21 e 40 dias. Em seguida, os animais foram sacrificados, as mandíbulas removidas cirurgicamente, fixadas em formalina e depois radiografadas em posição padronizada. As imagens radiográficas das lesões perirradiculares foram escaneadas e as imagens computadorizadas avaliadas quanto à área total das lesões usando software específico. Espécimes representativos foram preparados também para análise histológica. A análise radiográfica revelou que os ratos diabéticos apresentaram lesões periradiculares significativamente maiores quando comparados com os ratos normais, independentemente do período experimental (pUniversidade de São Paulo. Faculdade de Odontologia de Bauru2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/340210.1590/S1678-77572006000500013Journal of Applied Oral Science; Vol. 14 No. 5 (2006); 371-375 Journal of Applied Oral Science; Vol. 14 Núm. 5 (2006); 371-375 Journal of Applied Oral Science; v. 14 n. 5 (2006); 371-375 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3402/4092Copyright (c) 2006 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessArmada-Dias, LuciBreda, JorgeProvenzano, José ClaudioBreitenbach, MarisaRôças, Isabela das NevesGahyva, Sérgio Márcio MottaSiqueira Junior, José Freitas2012-04-27T11:55:16Zoai:revistas.usp.br:article/3402Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T11:55:16Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Development of periradicular lesions in normal and diabetic rats
Desenvolvimento de lesões perirradiculares em ratos normais e diabéticos
title Development of periradicular lesions in normal and diabetic rats
spellingShingle Development of periradicular lesions in normal and diabetic rats
Armada-Dias, Luci
Infecção endodôntica
Periodontite apical
Diabetes
Endodontic infection
Apical periodontitis
Diabetes
title_short Development of periradicular lesions in normal and diabetic rats
title_full Development of periradicular lesions in normal and diabetic rats
title_fullStr Development of periradicular lesions in normal and diabetic rats
title_full_unstemmed Development of periradicular lesions in normal and diabetic rats
title_sort Development of periradicular lesions in normal and diabetic rats
author Armada-Dias, Luci
author_facet Armada-Dias, Luci
Breda, Jorge
Provenzano, José Claudio
Breitenbach, Marisa
Rôças, Isabela das Neves
Gahyva, Sérgio Márcio Motta
Siqueira Junior, José Freitas
author_role author
author2 Breda, Jorge
Provenzano, José Claudio
Breitenbach, Marisa
Rôças, Isabela das Neves
Gahyva, Sérgio Márcio Motta
Siqueira Junior, José Freitas
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Armada-Dias, Luci
Breda, Jorge
Provenzano, José Claudio
Breitenbach, Marisa
Rôças, Isabela das Neves
Gahyva, Sérgio Márcio Motta
Siqueira Junior, José Freitas
dc.subject.por.fl_str_mv Infecção endodôntica
Periodontite apical
Diabetes
Endodontic infection
Apical periodontitis
Diabetes
topic Infecção endodôntica
Periodontite apical
Diabetes
Endodontic infection
Apical periodontitis
Diabetes
description Evidence suggests that diabetic patients are more significantly affected by problems of endodontic origin. This study sought to radiographically and histologically examine the development of periradicular inflammation in control and in diabetic rats after induction of pulpal infection. The pulps of the mandibular first molars of normal and streptozotocin-induced diabetic rats were exposed and left in contact with their oral cavities for 21 and 40 days. Afterwards, the animals were sacrificed, the mandibles were surgically removed, fixed in formalin and then radiographed in a standardized position. The radiographic images of the periradicular lesions were scanned and computerized images were evaluated for the total area of the lesions using a specific software. Representative specimens were also prepared for histopathological analysis. Radiographic analysis revealed that diabetic rats presented significantly larger periradicular lesions when compared with control rats, regardless of the experimental period (p
publishDate 2006
dc.date.none.fl_str_mv 2006-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3402
10.1590/S1678-77572006000500013
url https://www.revistas.usp.br/jaos/article/view/3402
identifier_str_mv 10.1590/S1678-77572006000500013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3402/4092
dc.rights.driver.fl_str_mv Copyright (c) 2006 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2006 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 14 No. 5 (2006); 371-375
Journal of Applied Oral Science; Vol. 14 Núm. 5 (2006); 371-375
Journal of Applied Oral Science; v. 14 n. 5 (2006); 371-375
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
_version_ 1800221672823848960

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