COVID-19 outcomes in people living with HIV: Peering through the waves

• Autor(a) principal: Sales, Thaís Lorenna Souza
• Data de Publicação: 2023
• Outros Autores: Souza-Silva, Maíra Viana Rego, Delfino-Pereira, Polianna, Neves, João Victor Baroni, Sacioto, Manuela Furtado, Assis, Vivian Costa Morais de, Duani, Helena, Oliveira, Neimy Ramos de, Sampaio, Natália da Cunha Severino, Ramos, Lucas Emanuel Ferreira, Schwarzbold, Alexandre Vargas, Jorge, Alzira de Oliveira, Scotton, Ana Luiza Bahia Alves, Castro, Bruno Mateus de, Silva, Carla Thais Cândida Alves da, Ramos, Carolina Marques, Anschau, Fernando, Botoni, Fernando Antonio, Grizende, Genna Maira Santos, Nascimento, Guilherme Fagundes, Ruschel, Karen Brasil, Menezes, Luanna Silva Monteiro, Castro, Luís César de, Nasi, Luiz Antônio, Carneiro, Marcelo, Godoy, Mariana Frizzo de, Nogueira, Matheus Carvalho Alves, Guimarães Júnior, Milton Henriques, Ziegelmann, Patricia Klarmann, Almeida, Rafaela Charão de, Francisco, Saionara Cristina, Silveira Neto, Sidney Teodoro, Araújo, Silvia Ferreira, Avelino-Silva, Thiago Junqueira, Aliberti, Márlon Juliano Romero, Pires, Magda Carvalho, Silva, Eduardo Sérgio da, Marcolino, Milena Soriano
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Clinics
• Texto Completo: https://www.revistas.usp.br/clinics/article/view/214022
• topic: COVID-19; Intensive care unit; Mechanical ventilation; Mortality

Objective: To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods: This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results: Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions: Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.