Impact of cytomegalovirus and grafts versus host disease on the dynamics of CD57+CD28-CD8+ T cells after bone marrow transplant

Detalhes bibliográficos
Autor(a) principal: Mendes, Ana Verena Almeida
Data de Publicação: 2008
Outros Autores: Kallas, Esper Georges, Benard, Gil, Pannuti, Cláudio Sérgio, Menezes, Reneé, Dulley, Frederico Luiz, Evans, Thomas George, Salomão, Reinaldo, Machado, Clarisse Martins
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/17758
Resumo: OBJECTIVES: The present study aimed to evaluate the dynamics of CD28 and CD57 expression in CD8+ T lymphocytes during cytomegalovirus viremia in bone marrow transplant recipients. METHODS: In a prospective study, blood samples were obtained once weekly once from 33 healthy volunteers and weekly from 33 patients. To evaluate the expression of CD57 and CD28 on CD8+ T lymphocytes, flow cytometry analysis was performed on blood samples for four months after bone marrow transplant, together with cytomegalovirus antigenemia assays. RESULTS: Compared to cytomegalovirus-seronegative healthy subjects, seropositive healthy subjects demonstrated a higher percentage of CD57+ and a lower percentage of CD28+ cells (p
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spelling Impact of cytomegalovirus and grafts versus host disease on the dynamics of CD57+CD28-CD8+ T cells after bone marrow transplant CytomegalovirusGraft versus host diseaseBone marrow transplantCD57 lymphocytesimmuno-constitution OBJECTIVES: The present study aimed to evaluate the dynamics of CD28 and CD57 expression in CD8+ T lymphocytes during cytomegalovirus viremia in bone marrow transplant recipients. METHODS: In a prospective study, blood samples were obtained once weekly once from 33 healthy volunteers and weekly from 33 patients. To evaluate the expression of CD57 and CD28 on CD8+ T lymphocytes, flow cytometry analysis was performed on blood samples for four months after bone marrow transplant, together with cytomegalovirus antigenemia assays. RESULTS: Compared to cytomegalovirus-seronegative healthy subjects, seropositive healthy subjects demonstrated a higher percentage of CD57+ and a lower percentage of CD28+ cells (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1775810.1590/S1807-59322008000500016Clinics; Vol. 63 No. 5 (2008); 667-676 Clinics; v. 63 n. 5 (2008); 667-676 Clinics; Vol. 63 Núm. 5 (2008); 667-676 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17758/19823Mendes, Ana Verena AlmeidaKallas, Esper GeorgesBenard, GilPannuti, Cláudio SérgioMenezes, ReneéDulley, Frederico LuizEvans, Thomas GeorgeSalomão, ReinaldoMachado, Clarisse Martinsinfo:eu-repo/semantics/openAccess2012-05-22T18:31:04Zoai:revistas.usp.br:article/17758Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:31:04Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Impact of cytomegalovirus and grafts versus host disease on the dynamics of CD57+CD28-CD8+ T cells after bone marrow transplant
title Impact of cytomegalovirus and grafts versus host disease on the dynamics of CD57+CD28-CD8+ T cells after bone marrow transplant
spellingShingle Impact of cytomegalovirus and grafts versus host disease on the dynamics of CD57+CD28-CD8+ T cells after bone marrow transplant
Mendes, Ana Verena Almeida
Cytomegalovirus
Graft versus host disease
Bone marrow transplant
CD57 lymphocytes
immuno-constitution
title_short Impact of cytomegalovirus and grafts versus host disease on the dynamics of CD57+CD28-CD8+ T cells after bone marrow transplant
title_full Impact of cytomegalovirus and grafts versus host disease on the dynamics of CD57+CD28-CD8+ T cells after bone marrow transplant
title_fullStr Impact of cytomegalovirus and grafts versus host disease on the dynamics of CD57+CD28-CD8+ T cells after bone marrow transplant
title_full_unstemmed Impact of cytomegalovirus and grafts versus host disease on the dynamics of CD57+CD28-CD8+ T cells after bone marrow transplant
title_sort Impact of cytomegalovirus and grafts versus host disease on the dynamics of CD57+CD28-CD8+ T cells after bone marrow transplant
author Mendes, Ana Verena Almeida
author_facet Mendes, Ana Verena Almeida
Kallas, Esper Georges
Benard, Gil
Pannuti, Cláudio Sérgio
Menezes, Reneé
Dulley, Frederico Luiz
Evans, Thomas George
Salomão, Reinaldo
Machado, Clarisse Martins
author_role author
author2 Kallas, Esper Georges
Benard, Gil
Pannuti, Cláudio Sérgio
Menezes, Reneé
Dulley, Frederico Luiz
Evans, Thomas George
Salomão, Reinaldo
Machado, Clarisse Martins
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mendes, Ana Verena Almeida
Kallas, Esper Georges
Benard, Gil
Pannuti, Cláudio Sérgio
Menezes, Reneé
Dulley, Frederico Luiz
Evans, Thomas George
Salomão, Reinaldo
Machado, Clarisse Martins
dc.subject.por.fl_str_mv Cytomegalovirus
Graft versus host disease
Bone marrow transplant
CD57 lymphocytes
immuno-constitution
topic Cytomegalovirus
Graft versus host disease
Bone marrow transplant
CD57 lymphocytes
immuno-constitution
description OBJECTIVES: The present study aimed to evaluate the dynamics of CD28 and CD57 expression in CD8+ T lymphocytes during cytomegalovirus viremia in bone marrow transplant recipients. METHODS: In a prospective study, blood samples were obtained once weekly once from 33 healthy volunteers and weekly from 33 patients. To evaluate the expression of CD57 and CD28 on CD8+ T lymphocytes, flow cytometry analysis was performed on blood samples for four months after bone marrow transplant, together with cytomegalovirus antigenemia assays. RESULTS: Compared to cytomegalovirus-seronegative healthy subjects, seropositive healthy subjects demonstrated a higher percentage of CD57+ and a lower percentage of CD28+ cells (p
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17758
10.1590/S1807-59322008000500016
url https://www.revistas.usp.br/clinics/article/view/17758
identifier_str_mv 10.1590/S1807-59322008000500016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17758/19823
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 63 No. 5 (2008); 667-676
Clinics; v. 63 n. 5 (2008); 667-676
Clinics; Vol. 63 Núm. 5 (2008); 667-676
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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