Clinical characteristics and evolution of 71 neonates born to mothers with COVID-19 at a tertiary center in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/213586 |
Resumo: | Introduction: Limited data are available on pregnant women with COVID-19 and their neonates. Objective: This study aimed to describe clinical characteristics and evolution from birth to discharge of a retrospective cohort of 71 neonates, with one set of twins, born to women with COVID-19 diagnosed at the end of pregnancy. The authors included all newborns admitted into a neonatal unit of a tertiary hospital in Brazil, between March 2020 and March 2021, whose unvaccinated mothers had COVID-19 symptoms and RT-PCR (Real-Time Polymerase Chain Reaction) for SARS-CoV-2 positive within fourteen days prior to delivery. Newborns to mothers with COVID-19 symptoms and negative tests for SARS-CoV-2 were excluded. Results: The main route of birth delivery was cesarean, corresponding to 60 pregnant women (84.5%). The foremost indications for cesarean were pregnant with critical disease (24.6%) and acute fetal distress (20.3%). The mean birth weight was 2452 g (865‒3870 g) and the mean gestational age was 345/7 weeks (25‒40 weeks). There were 45 premature newborns (63.3%), of which 21 newborns (29.5%) were less than 32 weeks of gestational age. RT-PCR for SARS-CoV-2 on oropharyngeal swabs was positive in 2 newborns (2.8%) and negative in the other 69 newborns (97.2%). Most newborns (51.4%) needed respiratory support. Therapeutic interventions during hospitalization were inotropic drugs (9.9%), antibiotics (22.8%), parenteral nutrition (26.8%), and phototherapy (46.5%). Conclusion: Maternal COVID-19 diagnosticated close to delivery has an impact on the first days of neonatal life. |
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Clinics |
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Clinical characteristics and evolution of 71 neonates born to mothers with COVID-19 at a tertiary center in BrazilNeonatologyCOVID-19NewbornBrazilIntroduction: Limited data are available on pregnant women with COVID-19 and their neonates. Objective: This study aimed to describe clinical characteristics and evolution from birth to discharge of a retrospective cohort of 71 neonates, with one set of twins, born to women with COVID-19 diagnosed at the end of pregnancy. The authors included all newborns admitted into a neonatal unit of a tertiary hospital in Brazil, between March 2020 and March 2021, whose unvaccinated mothers had COVID-19 symptoms and RT-PCR (Real-Time Polymerase Chain Reaction) for SARS-CoV-2 positive within fourteen days prior to delivery. Newborns to mothers with COVID-19 symptoms and negative tests for SARS-CoV-2 were excluded. Results: The main route of birth delivery was cesarean, corresponding to 60 pregnant women (84.5%). The foremost indications for cesarean were pregnant with critical disease (24.6%) and acute fetal distress (20.3%). The mean birth weight was 2452 g (865‒3870 g) and the mean gestational age was 345/7 weeks (25‒40 weeks). There were 45 premature newborns (63.3%), of which 21 newborns (29.5%) were less than 32 weeks of gestational age. RT-PCR for SARS-CoV-2 on oropharyngeal swabs was positive in 2 newborns (2.8%) and negative in the other 69 newborns (97.2%). Most newborns (51.4%) needed respiratory support. Therapeutic interventions during hospitalization were inotropic drugs (9.9%), antibiotics (22.8%), parenteral nutrition (26.8%), and phototherapy (46.5%). Conclusion: Maternal COVID-19 diagnosticated close to delivery has an impact on the first days of neonatal life.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2022-11-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21358610.1016/j.clinsp.2022.100136Clinics; Vol. 77 (2022); 100136Clinics; v. 77 (2022); 100136Clinics; Vol. 77 (2022); 1001361980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/213586/195670Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessDuarte, Bruna de PaulaKrebs, Vera Lucia JornadaCalil, Valdenise Martins Laurindo TumaCarvalho, Werther Brunow deGibelli, Maria Augusta Bento CicaroniFrancisco, Rossana Pulcineli Vieira2023-07-06T13:05:00Zoai:revistas.usp.br:article/213586Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:05Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Clinical characteristics and evolution of 71 neonates born to mothers with COVID-19 at a tertiary center in Brazil |
title |
Clinical characteristics and evolution of 71 neonates born to mothers with COVID-19 at a tertiary center in Brazil |
spellingShingle |
Clinical characteristics and evolution of 71 neonates born to mothers with COVID-19 at a tertiary center in Brazil Duarte, Bruna de Paula Neonatology COVID-19 Newborn Brazil |
title_short |
Clinical characteristics and evolution of 71 neonates born to mothers with COVID-19 at a tertiary center in Brazil |
title_full |
Clinical characteristics and evolution of 71 neonates born to mothers with COVID-19 at a tertiary center in Brazil |
title_fullStr |
Clinical characteristics and evolution of 71 neonates born to mothers with COVID-19 at a tertiary center in Brazil |
title_full_unstemmed |
Clinical characteristics and evolution of 71 neonates born to mothers with COVID-19 at a tertiary center in Brazil |
title_sort |
Clinical characteristics and evolution of 71 neonates born to mothers with COVID-19 at a tertiary center in Brazil |
author |
Duarte, Bruna de Paula |
author_facet |
Duarte, Bruna de Paula Krebs, Vera Lucia Jornada Calil, Valdenise Martins Laurindo Tuma Carvalho, Werther Brunow de Gibelli, Maria Augusta Bento Cicaroni Francisco, Rossana Pulcineli Vieira |
author_role |
author |
author2 |
Krebs, Vera Lucia Jornada Calil, Valdenise Martins Laurindo Tuma Carvalho, Werther Brunow de Gibelli, Maria Augusta Bento Cicaroni Francisco, Rossana Pulcineli Vieira |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Duarte, Bruna de Paula Krebs, Vera Lucia Jornada Calil, Valdenise Martins Laurindo Tuma Carvalho, Werther Brunow de Gibelli, Maria Augusta Bento Cicaroni Francisco, Rossana Pulcineli Vieira |
dc.subject.por.fl_str_mv |
Neonatology COVID-19 Newborn Brazil |
topic |
Neonatology COVID-19 Newborn Brazil |
description |
Introduction: Limited data are available on pregnant women with COVID-19 and their neonates. Objective: This study aimed to describe clinical characteristics and evolution from birth to discharge of a retrospective cohort of 71 neonates, with one set of twins, born to women with COVID-19 diagnosed at the end of pregnancy. The authors included all newborns admitted into a neonatal unit of a tertiary hospital in Brazil, between March 2020 and March 2021, whose unvaccinated mothers had COVID-19 symptoms and RT-PCR (Real-Time Polymerase Chain Reaction) for SARS-CoV-2 positive within fourteen days prior to delivery. Newborns to mothers with COVID-19 symptoms and negative tests for SARS-CoV-2 were excluded. Results: The main route of birth delivery was cesarean, corresponding to 60 pregnant women (84.5%). The foremost indications for cesarean were pregnant with critical disease (24.6%) and acute fetal distress (20.3%). The mean birth weight was 2452 g (865‒3870 g) and the mean gestational age was 345/7 weeks (25‒40 weeks). There were 45 premature newborns (63.3%), of which 21 newborns (29.5%) were less than 32 weeks of gestational age. RT-PCR for SARS-CoV-2 on oropharyngeal swabs was positive in 2 newborns (2.8%) and negative in the other 69 newborns (97.2%). Most newborns (51.4%) needed respiratory support. Therapeutic interventions during hospitalization were inotropic drugs (9.9%), antibiotics (22.8%), parenteral nutrition (26.8%), and phototherapy (46.5%). Conclusion: Maternal COVID-19 diagnosticated close to delivery has an impact on the first days of neonatal life. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/213586 10.1016/j.clinsp.2022.100136 |
url |
https://www.revistas.usp.br/clinics/article/view/213586 |
identifier_str_mv |
10.1016/j.clinsp.2022.100136 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/213586/195670 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 77 (2022); 100136 Clinics; v. 77 (2022); 100136 Clinics; Vol. 77 (2022); 100136 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222767019196416 |