Local and systemic effects of fibrin and cyanoacrylate adhesives on lung lesions in rabbits
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/141018 |
Resumo: | OBJECTIVES: Tissue adhesives can be used to prevent pulmonary air leaks, which frequently occur after lung interventions. The objective of this study is to evaluate local and systemic effects of fibrin and cyanoacrylate tissue adhesives on lung lesions in rabbits. METHODS: Eighteen rabbits were submitted to videothoracoscopy + lung incision alone (control) or videothoracoscopy + lung incision + local application of fibrin or cyanoacrylate adhesive. Blood samples were collected and assessed for leukocyte, neutrophil and lymphocyte counts and interleukin-8 levels preoperatively and at 48 hours and 28 days post-operatively. After 28 days, the animals were euthanized for gross examination of the lung surface, and lung fragments were excised for histopathological analysis. RESULTS: Fibrin and cyanoacrylate produced similar adhesion scores of the lung to the parietal pleura. Microscopic analysis revealed uniform low-cellular tissue infiltration in the fibrin group and an intense tissue reaction characterized by dense inflammatory infiltration of granulocytes, giant cells and necrosis in the cyanoacrylate group. No changes were detected in the leukocyte, neutrophil or lymphocyte count at any time-point, while the interleukin-8 levels were increased in the fibrin and cyanoacrylate groups after 48 hours compared with the pre-operative control levels (p |
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Clinics |
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Local and systemic effects of fibrin and cyanoacrylate adhesives on lung lesions in rabbitsThoracic SurgeryCyanoacrylateFibrinTissue AdhesivesSystemic EffectsOBJECTIVES: Tissue adhesives can be used to prevent pulmonary air leaks, which frequently occur after lung interventions. The objective of this study is to evaluate local and systemic effects of fibrin and cyanoacrylate tissue adhesives on lung lesions in rabbits. METHODS: Eighteen rabbits were submitted to videothoracoscopy + lung incision alone (control) or videothoracoscopy + lung incision + local application of fibrin or cyanoacrylate adhesive. Blood samples were collected and assessed for leukocyte, neutrophil and lymphocyte counts and interleukin-8 levels preoperatively and at 48 hours and 28 days post-operatively. After 28 days, the animals were euthanized for gross examination of the lung surface, and lung fragments were excised for histopathological analysis. RESULTS: Fibrin and cyanoacrylate produced similar adhesion scores of the lung to the parietal pleura. Microscopic analysis revealed uniform low-cellular tissue infiltration in the fibrin group and an intense tissue reaction characterized by dense inflammatory infiltration of granulocytes, giant cells and necrosis in the cyanoacrylate group. No changes were detected in the leukocyte, neutrophil or lymphocyte count at any time-point, while the interleukin-8 levels were increased in the fibrin and cyanoacrylate groups after 48 hours compared with the pre-operative control levels (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/14101810.6061/clinics/2017(10)06Clinics; Vol. 72 No. 10 (2017); 624-628Clinics; v. 72 n. 10 (2017); 624-628Clinics; Vol. 72 Núm. 10 (2017); 624-6281980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/141018/136084Copyright (c) 2017 Clinicsinfo:eu-repo/semantics/openAccessCarvalho, Marcus V.H.Marchi, EvaldoFruchi, Andre J.Dias, Bruno V.B.Pinto, Clovis L.dos Santos, Geovane R.Acencio, Milena M.P.2017-11-27T13:14:34Zoai:revistas.usp.br:article/141018Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2017-11-27T13:14:34Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Local and systemic effects of fibrin and cyanoacrylate adhesives on lung lesions in rabbits |
title |
Local and systemic effects of fibrin and cyanoacrylate adhesives on lung lesions in rabbits |
spellingShingle |
Local and systemic effects of fibrin and cyanoacrylate adhesives on lung lesions in rabbits Carvalho, Marcus V.H. Thoracic Surgery Cyanoacrylate Fibrin Tissue Adhesives Systemic Effects |
title_short |
Local and systemic effects of fibrin and cyanoacrylate adhesives on lung lesions in rabbits |
title_full |
Local and systemic effects of fibrin and cyanoacrylate adhesives on lung lesions in rabbits |
title_fullStr |
Local and systemic effects of fibrin and cyanoacrylate adhesives on lung lesions in rabbits |
title_full_unstemmed |
Local and systemic effects of fibrin and cyanoacrylate adhesives on lung lesions in rabbits |
title_sort |
Local and systemic effects of fibrin and cyanoacrylate adhesives on lung lesions in rabbits |
author |
Carvalho, Marcus V.H. |
author_facet |
Carvalho, Marcus V.H. Marchi, Evaldo Fruchi, Andre J. Dias, Bruno V.B. Pinto, Clovis L. dos Santos, Geovane R. Acencio, Milena M.P. |
author_role |
author |
author2 |
Marchi, Evaldo Fruchi, Andre J. Dias, Bruno V.B. Pinto, Clovis L. dos Santos, Geovane R. Acencio, Milena M.P. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, Marcus V.H. Marchi, Evaldo Fruchi, Andre J. Dias, Bruno V.B. Pinto, Clovis L. dos Santos, Geovane R. Acencio, Milena M.P. |
dc.subject.por.fl_str_mv |
Thoracic Surgery Cyanoacrylate Fibrin Tissue Adhesives Systemic Effects |
topic |
Thoracic Surgery Cyanoacrylate Fibrin Tissue Adhesives Systemic Effects |
description |
OBJECTIVES: Tissue adhesives can be used to prevent pulmonary air leaks, which frequently occur after lung interventions. The objective of this study is to evaluate local and systemic effects of fibrin and cyanoacrylate tissue adhesives on lung lesions in rabbits. METHODS: Eighteen rabbits were submitted to videothoracoscopy + lung incision alone (control) or videothoracoscopy + lung incision + local application of fibrin or cyanoacrylate adhesive. Blood samples were collected and assessed for leukocyte, neutrophil and lymphocyte counts and interleukin-8 levels preoperatively and at 48 hours and 28 days post-operatively. After 28 days, the animals were euthanized for gross examination of the lung surface, and lung fragments were excised for histopathological analysis. RESULTS: Fibrin and cyanoacrylate produced similar adhesion scores of the lung to the parietal pleura. Microscopic analysis revealed uniform low-cellular tissue infiltration in the fibrin group and an intense tissue reaction characterized by dense inflammatory infiltration of granulocytes, giant cells and necrosis in the cyanoacrylate group. No changes were detected in the leukocyte, neutrophil or lymphocyte count at any time-point, while the interleukin-8 levels were increased in the fibrin and cyanoacrylate groups after 48 hours compared with the pre-operative control levels (p |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/141018 10.6061/clinics/2017(10)06 |
url |
https://www.revistas.usp.br/clinics/article/view/141018 |
identifier_str_mv |
10.6061/clinics/2017(10)06 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/141018/136084 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 72 No. 10 (2017); 624-628 Clinics; v. 72 n. 10 (2017); 624-628 Clinics; Vol. 72 Núm. 10 (2017); 624-628 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222763264245760 |