Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/141022 |
Resumo: | OBJECTIVES: Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal damage. METHODS: We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein levels in the plasma of patients who underwent liver resection. RESULTS: We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle maneuver is not performed. CONCLUSION: We propose the use of insulin-like growth factor binding protein-1 as a novel biomarker of intestinal damage in such situations. |
id |
USP-19_17af99fdbb617d0606ab32b9ac2a0327 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/141022 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injuryLiverInflammationIntestinal BarrierBacterial TranslocationIGFBP-1OBJECTIVES: Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal damage. METHODS: We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein levels in the plasma of patients who underwent liver resection. RESULTS: We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle maneuver is not performed. CONCLUSION: We propose the use of insulin-like growth factor binding protein-1 as a novel biomarker of intestinal damage in such situations.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/14102210.6061/clinics/2017(10)10Clinics; Vol. 72 No. 10 (2017); 645-648Clinics; v. 72 n. 10 (2017); 645-648Clinics; Vol. 72 Núm. 10 (2017); 645-6481980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/141022/136088Copyright (c) 2017 Clinicsinfo:eu-repo/semantics/openAccessBarbeiro, Hermes VieiraMachado, Marcel Autran Césarde Souza, Heraldo Possoloda Silva, Fabiano PinheiroMachado, Marcel Cerqueira César2017-11-27T13:14:34Zoai:revistas.usp.br:article/141022Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2017-11-27T13:14:34Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury |
title |
Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury |
spellingShingle |
Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury Barbeiro, Hermes Vieira Liver Inflammation Intestinal Barrier Bacterial Translocation IGFBP-1 |
title_short |
Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury |
title_full |
Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury |
title_fullStr |
Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury |
title_full_unstemmed |
Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury |
title_sort |
Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury |
author |
Barbeiro, Hermes Vieira |
author_facet |
Barbeiro, Hermes Vieira Machado, Marcel Autran César de Souza, Heraldo Possolo da Silva, Fabiano Pinheiro Machado, Marcel Cerqueira César |
author_role |
author |
author2 |
Machado, Marcel Autran César de Souza, Heraldo Possolo da Silva, Fabiano Pinheiro Machado, Marcel Cerqueira César |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Barbeiro, Hermes Vieira Machado, Marcel Autran César de Souza, Heraldo Possolo da Silva, Fabiano Pinheiro Machado, Marcel Cerqueira César |
dc.subject.por.fl_str_mv |
Liver Inflammation Intestinal Barrier Bacterial Translocation IGFBP-1 |
topic |
Liver Inflammation Intestinal Barrier Bacterial Translocation IGFBP-1 |
description |
OBJECTIVES: Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal damage. METHODS: We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein levels in the plasma of patients who underwent liver resection. RESULTS: We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle maneuver is not performed. CONCLUSION: We propose the use of insulin-like growth factor binding protein-1 as a novel biomarker of intestinal damage in such situations. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/141022 10.6061/clinics/2017(10)10 |
url |
https://www.revistas.usp.br/clinics/article/view/141022 |
identifier_str_mv |
10.6061/clinics/2017(10)10 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/141022/136088 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 72 No. 10 (2017); 645-648 Clinics; v. 72 n. 10 (2017); 645-648 Clinics; Vol. 72 Núm. 10 (2017); 645-648 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222763270537216 |