Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/17896 |
Resumo: | Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor size and progression, and as an index of biochemical improvement of medullary thyroid carcinomas. Although measurement of calcitonin is a highly sensitive method for the detection of medullary thyroid carcinoma, it presents a low specificity for this tumor. Several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. Several cases of thyroid nodules associated with increased values of calcitonin are not medullary thyroid carcinomas, but rather are related to other conditions, such as hypercalcemias, hypergastrinemias, neuroendocrine tumors, renal insufficiency, papillary and follicular thyroid carcinomas, and goiter. Furthermore, prolonged treatment with omeprazole (>; 2-4 months), beta-blockers, glucocorticoids and potential secretagogues, have been associated with hypercalcitoninemia. An association between calcitonin levels and chronic auto-immune thyroiditis remains controversial. Patients with calcitonin levels >;100 pg/mL have a high risk for medullary thyroid carcinoma (~90%-100%), whereas patients with values from 10 to 100 pg/mL (normal values: |
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Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma CalcitoninFalse-positive testRET mutationTotal thyroidectomy Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor size and progression, and as an index of biochemical improvement of medullary thyroid carcinomas. Although measurement of calcitonin is a highly sensitive method for the detection of medullary thyroid carcinoma, it presents a low specificity for this tumor. Several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. Several cases of thyroid nodules associated with increased values of calcitonin are not medullary thyroid carcinomas, but rather are related to other conditions, such as hypercalcemias, hypergastrinemias, neuroendocrine tumors, renal insufficiency, papillary and follicular thyroid carcinomas, and goiter. Furthermore, prolonged treatment with omeprazole (>; 2-4 months), beta-blockers, glucocorticoids and potential secretagogues, have been associated with hypercalcitoninemia. An association between calcitonin levels and chronic auto-immune thyroiditis remains controversial. Patients with calcitonin levels >;100 pg/mL have a high risk for medullary thyroid carcinoma (~90%-100%), whereas patients with values from 10 to 100 pg/mL (normal values: Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1789610.1590/S1807-59322009000700015Clinics; Vol. 64 No. 7 (2009); 699-706 Clinics; v. 64 n. 7 (2009); 699-706 Clinics; Vol. 64 Núm. 7 (2009); 699-706 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17896/19961Toledo, Sergio PALourenço Jr, Delmar MSantos, Marcelo AugustoTavares, Marcos RToledo, Rodrigo ACorreia-Deur, Joya Emilie de Menezesinfo:eu-repo/semantics/openAccess2012-05-22T18:42:25Zoai:revistas.usp.br:article/17896Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:42:25Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma |
title |
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma |
spellingShingle |
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma Toledo, Sergio PA Calcitonin False-positive test RET mutation Total thyroidectomy |
title_short |
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma |
title_full |
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma |
title_fullStr |
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma |
title_full_unstemmed |
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma |
title_sort |
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma |
author |
Toledo, Sergio PA |
author_facet |
Toledo, Sergio PA Lourenço Jr, Delmar M Santos, Marcelo Augusto Tavares, Marcos R Toledo, Rodrigo A Correia-Deur, Joya Emilie de Menezes |
author_role |
author |
author2 |
Lourenço Jr, Delmar M Santos, Marcelo Augusto Tavares, Marcos R Toledo, Rodrigo A Correia-Deur, Joya Emilie de Menezes |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Toledo, Sergio PA Lourenço Jr, Delmar M Santos, Marcelo Augusto Tavares, Marcos R Toledo, Rodrigo A Correia-Deur, Joya Emilie de Menezes |
dc.subject.por.fl_str_mv |
Calcitonin False-positive test RET mutation Total thyroidectomy |
topic |
Calcitonin False-positive test RET mutation Total thyroidectomy |
description |
Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor size and progression, and as an index of biochemical improvement of medullary thyroid carcinomas. Although measurement of calcitonin is a highly sensitive method for the detection of medullary thyroid carcinoma, it presents a low specificity for this tumor. Several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. Several cases of thyroid nodules associated with increased values of calcitonin are not medullary thyroid carcinomas, but rather are related to other conditions, such as hypercalcemias, hypergastrinemias, neuroendocrine tumors, renal insufficiency, papillary and follicular thyroid carcinomas, and goiter. Furthermore, prolonged treatment with omeprazole (>; 2-4 months), beta-blockers, glucocorticoids and potential secretagogues, have been associated with hypercalcitoninemia. An association between calcitonin levels and chronic auto-immune thyroiditis remains controversial. Patients with calcitonin levels >;100 pg/mL have a high risk for medullary thyroid carcinoma (~90%-100%), whereas patients with values from 10 to 100 pg/mL (normal values: |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/17896 10.1590/S1807-59322009000700015 |
url |
https://www.revistas.usp.br/clinics/article/view/17896 |
identifier_str_mv |
10.1590/S1807-59322009000700015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/17896/19961 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 64 No. 7 (2009); 699-706 Clinics; v. 64 n. 7 (2009); 699-706 Clinics; Vol. 64 Núm. 7 (2009); 699-706 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222754026291200 |