Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma

Detalhes bibliográficos
Autor(a) principal: Toledo, Sergio PA
Data de Publicação: 2009
Outros Autores: Lourenço Jr, Delmar M, Santos, Marcelo Augusto, Tavares, Marcos R, Toledo, Rodrigo A, Correia-Deur, Joya Emilie de Menezes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/17896
Resumo: Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor size and progression, and as an index of biochemical improvement of medullary thyroid carcinomas. Although measurement of calcitonin is a highly sensitive method for the detection of medullary thyroid carcinoma, it presents a low specificity for this tumor. Several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. Several cases of thyroid nodules associated with increased values of calcitonin are not medullary thyroid carcinomas, but rather are related to other conditions, such as hypercalcemias, hypergastrinemias, neuroendocrine tumors, renal insufficiency, papillary and follicular thyroid carcinomas, and goiter. Furthermore, prolonged treatment with omeprazole (>; 2-4 months), beta-blockers, glucocorticoids and potential secretagogues, have been associated with hypercalcitoninemia. An association between calcitonin levels and chronic auto-immune thyroiditis remains controversial. Patients with calcitonin levels >;100 pg/mL have a high risk for medullary thyroid carcinoma (~90%-100%), whereas patients with values from 10 to 100 pg/mL (normal values:
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spelling Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma CalcitoninFalse-positive testRET mutationTotal thyroidectomy Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor size and progression, and as an index of biochemical improvement of medullary thyroid carcinomas. Although measurement of calcitonin is a highly sensitive method for the detection of medullary thyroid carcinoma, it presents a low specificity for this tumor. Several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. Several cases of thyroid nodules associated with increased values of calcitonin are not medullary thyroid carcinomas, but rather are related to other conditions, such as hypercalcemias, hypergastrinemias, neuroendocrine tumors, renal insufficiency, papillary and follicular thyroid carcinomas, and goiter. Furthermore, prolonged treatment with omeprazole (>; 2-4 months), beta-blockers, glucocorticoids and potential secretagogues, have been associated with hypercalcitoninemia. An association between calcitonin levels and chronic auto-immune thyroiditis remains controversial. Patients with calcitonin levels >;100 pg/mL have a high risk for medullary thyroid carcinoma (~90%-100%), whereas patients with values from 10 to 100 pg/mL (normal values: Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1789610.1590/S1807-59322009000700015Clinics; Vol. 64 No. 7 (2009); 699-706 Clinics; v. 64 n. 7 (2009); 699-706 Clinics; Vol. 64 Núm. 7 (2009); 699-706 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17896/19961Toledo, Sergio PALourenço Jr, Delmar MSantos, Marcelo AugustoTavares, Marcos RToledo, Rodrigo ACorreia-Deur, Joya Emilie de Menezesinfo:eu-repo/semantics/openAccess2012-05-22T18:42:25Zoai:revistas.usp.br:article/17896Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:42:25Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma
title Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma
spellingShingle Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma
Toledo, Sergio PA
Calcitonin
False-positive test
RET mutation
Total thyroidectomy
title_short Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma
title_full Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma
title_fullStr Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma
title_full_unstemmed Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma
title_sort Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma
author Toledo, Sergio PA
author_facet Toledo, Sergio PA
Lourenço Jr, Delmar M
Santos, Marcelo Augusto
Tavares, Marcos R
Toledo, Rodrigo A
Correia-Deur, Joya Emilie de Menezes
author_role author
author2 Lourenço Jr, Delmar M
Santos, Marcelo Augusto
Tavares, Marcos R
Toledo, Rodrigo A
Correia-Deur, Joya Emilie de Menezes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Toledo, Sergio PA
Lourenço Jr, Delmar M
Santos, Marcelo Augusto
Tavares, Marcos R
Toledo, Rodrigo A
Correia-Deur, Joya Emilie de Menezes
dc.subject.por.fl_str_mv Calcitonin
False-positive test
RET mutation
Total thyroidectomy
topic Calcitonin
False-positive test
RET mutation
Total thyroidectomy
description Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor size and progression, and as an index of biochemical improvement of medullary thyroid carcinomas. Although measurement of calcitonin is a highly sensitive method for the detection of medullary thyroid carcinoma, it presents a low specificity for this tumor. Several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. Several cases of thyroid nodules associated with increased values of calcitonin are not medullary thyroid carcinomas, but rather are related to other conditions, such as hypercalcemias, hypergastrinemias, neuroendocrine tumors, renal insufficiency, papillary and follicular thyroid carcinomas, and goiter. Furthermore, prolonged treatment with omeprazole (>; 2-4 months), beta-blockers, glucocorticoids and potential secretagogues, have been associated with hypercalcitoninemia. An association between calcitonin levels and chronic auto-immune thyroiditis remains controversial. Patients with calcitonin levels >;100 pg/mL have a high risk for medullary thyroid carcinoma (~90%-100%), whereas patients with values from 10 to 100 pg/mL (normal values:
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17896
10.1590/S1807-59322009000700015
url https://www.revistas.usp.br/clinics/article/view/17896
identifier_str_mv 10.1590/S1807-59322009000700015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17896/19961
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 64 No. 7 (2009); 699-706
Clinics; v. 64 n. 7 (2009); 699-706
Clinics; Vol. 64 Núm. 7 (2009); 699-706
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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