Lifetime psychopathology among the offspring of Bipolar I parents

Detalhes bibliográficos
Autor(a) principal: Zappitelli, Marcelo C.
Data de Publicação: 2011
Outros Autores: Bordin, Isabel A., Hatch, John P., Caetano, Sheila C., Zunta-Soares, Giovana, Olvera, Rene L., Soares, Jair C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/19544
Resumo: BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results.
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spelling Lifetime psychopathology among the offspring of Bipolar I parents Bipolar DisorderOffspringPsychopathologyChildAdolescent BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1954410.1590/S1807-59322011000500003Clinics; Vol. 66 No. 5 (2011); 725-730 Clinics; v. 66 n. 5 (2011); 725-730 Clinics; Vol. 66 Núm. 5 (2011); 725-730 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19544/21607Zappitelli, Marcelo C.Bordin, Isabel A.Hatch, John P.Caetano, Sheila C.Zunta-Soares, GiovanaOlvera, Rene L.Soares, Jair C.info:eu-repo/semantics/openAccess2012-05-23T16:47:47Zoai:revistas.usp.br:article/19544Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:47:47Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Lifetime psychopathology among the offspring of Bipolar I parents
title Lifetime psychopathology among the offspring of Bipolar I parents
spellingShingle Lifetime psychopathology among the offspring of Bipolar I parents
Zappitelli, Marcelo C.
Bipolar Disorder
Offspring
Psychopathology
Child
Adolescent
title_short Lifetime psychopathology among the offspring of Bipolar I parents
title_full Lifetime psychopathology among the offspring of Bipolar I parents
title_fullStr Lifetime psychopathology among the offspring of Bipolar I parents
title_full_unstemmed Lifetime psychopathology among the offspring of Bipolar I parents
title_sort Lifetime psychopathology among the offspring of Bipolar I parents
author Zappitelli, Marcelo C.
author_facet Zappitelli, Marcelo C.
Bordin, Isabel A.
Hatch, John P.
Caetano, Sheila C.
Zunta-Soares, Giovana
Olvera, Rene L.
Soares, Jair C.
author_role author
author2 Bordin, Isabel A.
Hatch, John P.
Caetano, Sheila C.
Zunta-Soares, Giovana
Olvera, Rene L.
Soares, Jair C.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zappitelli, Marcelo C.
Bordin, Isabel A.
Hatch, John P.
Caetano, Sheila C.
Zunta-Soares, Giovana
Olvera, Rene L.
Soares, Jair C.
dc.subject.por.fl_str_mv Bipolar Disorder
Offspring
Psychopathology
Child
Adolescent
topic Bipolar Disorder
Offspring
Psychopathology
Child
Adolescent
description BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19544
10.1590/S1807-59322011000500003
url https://www.revistas.usp.br/clinics/article/view/19544
identifier_str_mv 10.1590/S1807-59322011000500003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19544/21607
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 66 No. 5 (2011); 725-730
Clinics; v. 66 n. 5 (2011); 725-730
Clinics; Vol. 66 Núm. 5 (2011); 725-730
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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