Lifetime psychopathology among the offspring of Bipolar I parents
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/19544 |
Resumo: | BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results. |
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Lifetime psychopathology among the offspring of Bipolar I parents Bipolar DisorderOffspringPsychopathologyChildAdolescent BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1954410.1590/S1807-59322011000500003Clinics; Vol. 66 No. 5 (2011); 725-730 Clinics; v. 66 n. 5 (2011); 725-730 Clinics; Vol. 66 Núm. 5 (2011); 725-730 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19544/21607Zappitelli, Marcelo C.Bordin, Isabel A.Hatch, John P.Caetano, Sheila C.Zunta-Soares, GiovanaOlvera, Rene L.Soares, Jair C.info:eu-repo/semantics/openAccess2012-05-23T16:47:47Zoai:revistas.usp.br:article/19544Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:47:47Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Lifetime psychopathology among the offspring of Bipolar I parents |
title |
Lifetime psychopathology among the offspring of Bipolar I parents |
spellingShingle |
Lifetime psychopathology among the offspring of Bipolar I parents Zappitelli, Marcelo C. Bipolar Disorder Offspring Psychopathology Child Adolescent |
title_short |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_full |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_fullStr |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_full_unstemmed |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_sort |
Lifetime psychopathology among the offspring of Bipolar I parents |
author |
Zappitelli, Marcelo C. |
author_facet |
Zappitelli, Marcelo C. Bordin, Isabel A. Hatch, John P. Caetano, Sheila C. Zunta-Soares, Giovana Olvera, Rene L. Soares, Jair C. |
author_role |
author |
author2 |
Bordin, Isabel A. Hatch, John P. Caetano, Sheila C. Zunta-Soares, Giovana Olvera, Rene L. Soares, Jair C. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Zappitelli, Marcelo C. Bordin, Isabel A. Hatch, John P. Caetano, Sheila C. Zunta-Soares, Giovana Olvera, Rene L. Soares, Jair C. |
dc.subject.por.fl_str_mv |
Bipolar Disorder Offspring Psychopathology Child Adolescent |
topic |
Bipolar Disorder Offspring Psychopathology Child Adolescent |
description |
BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19544 10.1590/S1807-59322011000500003 |
url |
https://www.revistas.usp.br/clinics/article/view/19544 |
identifier_str_mv |
10.1590/S1807-59322011000500003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19544/21607 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 66 No. 5 (2011); 725-730 Clinics; v. 66 n. 5 (2011); 725-730 Clinics; Vol. 66 Núm. 5 (2011); 725-730 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222757749784576 |