Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/160321 |
Resumo: | The efficacy and toxicity of radionuclide therapy are believed to be directly related to the radiation doses received by target tissues; however, nuclear medicine therapy continues to be based primarily on the administration of empirical activities to patients and less frequently on the use of internal dosimetry for individual therapeutic planning. This review aimed to critically describe the techniques and clinical evidence of dosimetry as a tool for therapeutic planning and the main limitations to its implementation in clinical practice. The present article is a nonsystematic review of voxel-based dosimetry. Clinical evidence pointing to a correlation between the radiation dose and therapeutic response in various diseases, such as thyroid carcinoma, neuroendocrine tumors and prostate cancer, is reviewed. Its limitations include technical aspects related to image acquisition and processing and the lack of randomized clinical trials demonstrating the impact of dosimetry on patient therapy. A more widespread use of dosimetry in therapeutic planning involves the development of user-friendly dosimetric protocols and confirmation that dose estimation implies good efficacy and low treatment-related toxicity. |
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Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planningNuclear MedicineRadionuclide ImagingIn vivo DosimetryThe efficacy and toxicity of radionuclide therapy are believed to be directly related to the radiation doses received by target tissues; however, nuclear medicine therapy continues to be based primarily on the administration of empirical activities to patients and less frequently on the use of internal dosimetry for individual therapeutic planning. This review aimed to critically describe the techniques and clinical evidence of dosimetry as a tool for therapeutic planning and the main limitations to its implementation in clinical practice. The present article is a nonsystematic review of voxel-based dosimetry. Clinical evidence pointing to a correlation between the radiation dose and therapeutic response in various diseases, such as thyroid carcinoma, neuroendocrine tumors and prostate cancer, is reviewed. Its limitations include technical aspects related to image acquisition and processing and the lack of randomized clinical trials demonstrating the impact of dosimetry on patient therapy. A more widespread use of dosimetry in therapeutic planning involves the development of user-friendly dosimetric protocols and confirmation that dose estimation implies good efficacy and low treatment-related toxicity.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-07-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/16032110.6061/clinics/2019/e835Clinics; v. 74 (2019); e835Clinics; Vol. 74 (2019); e835Clinics; Vol. 74 (2019); e8351980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/160321/154668https://www.revistas.usp.br/clinics/article/view/160321/154669Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessSapienza, Marcelo TatitWillegaignon, José2019-09-09T10:59:03Zoai:revistas.usp.br:article/160321Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-09-09T10:59:03Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning |
title |
Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning |
spellingShingle |
Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning Sapienza, Marcelo Tatit Nuclear Medicine Radionuclide Imaging In vivo Dosimetry |
title_short |
Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning |
title_full |
Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning |
title_fullStr |
Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning |
title_full_unstemmed |
Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning |
title_sort |
Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning |
author |
Sapienza, Marcelo Tatit |
author_facet |
Sapienza, Marcelo Tatit Willegaignon, José |
author_role |
author |
author2 |
Willegaignon, José |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Sapienza, Marcelo Tatit Willegaignon, José |
dc.subject.por.fl_str_mv |
Nuclear Medicine Radionuclide Imaging In vivo Dosimetry |
topic |
Nuclear Medicine Radionuclide Imaging In vivo Dosimetry |
description |
The efficacy and toxicity of radionuclide therapy are believed to be directly related to the radiation doses received by target tissues; however, nuclear medicine therapy continues to be based primarily on the administration of empirical activities to patients and less frequently on the use of internal dosimetry for individual therapeutic planning. This review aimed to critically describe the techniques and clinical evidence of dosimetry as a tool for therapeutic planning and the main limitations to its implementation in clinical practice. The present article is a nonsystematic review of voxel-based dosimetry. Clinical evidence pointing to a correlation between the radiation dose and therapeutic response in various diseases, such as thyroid carcinoma, neuroendocrine tumors and prostate cancer, is reviewed. Its limitations include technical aspects related to image acquisition and processing and the lack of randomized clinical trials demonstrating the impact of dosimetry on patient therapy. A more widespread use of dosimetry in therapeutic planning involves the development of user-friendly dosimetric protocols and confirmation that dose estimation implies good efficacy and low treatment-related toxicity. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-07-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/160321 10.6061/clinics/2019/e835 |
url |
https://www.revistas.usp.br/clinics/article/view/160321 |
identifier_str_mv |
10.6061/clinics/2019/e835 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/160321/154668 https://www.revistas.usp.br/clinics/article/view/160321/154669 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; v. 74 (2019); e835 Clinics; Vol. 74 (2019); e835 Clinics; Vol. 74 (2019); e835 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1787713181088481280 |