Second hand tobacco smoke adversely affects the bone of immature rats
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/142558 |
Resumo: | OBJECTIVES: To evaluate the influence of secondhand cigarette smoke exposure on longitudinal growth of the tibia of growing rats and some parameters of bone quality. METHODS: Forty female rats were randomly divided into four groups: control: rats were sham exposed; 30 days: rats were exposed to tobacco smoke for 30 days; 45 days: rats were exposed to tobacco smoke for 45 days; and 60 days: rats were exposed to tobacco smoke for 60 days. Blood samples were collected to evaluate the levels of cotinine and alkaline phosphatase. Both tibias were dissected and weighed; the lengths were measured, and the bones were then stored in a freezer for analysis of bone mineral content and mechanical resistance (maximal load and stiffness). RESULTS: Exposure of rats to tobacco smoke significantly compromised bone health, suggesting that the harmful effects may be time dependent. Harmful effects on bone growth were detected and were more pronounced at 60-day follow-ups with a 41.8% reduction in alkaline phosphatase levels (p |
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Clinics |
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Second hand tobacco smoke adversely affects the bone of immature ratsSmokingBone DevelopmentBone DensityTibiaRatsOBJECTIVES: To evaluate the influence of secondhand cigarette smoke exposure on longitudinal growth of the tibia of growing rats and some parameters of bone quality. METHODS: Forty female rats were randomly divided into four groups: control: rats were sham exposed; 30 days: rats were exposed to tobacco smoke for 30 days; 45 days: rats were exposed to tobacco smoke for 45 days; and 60 days: rats were exposed to tobacco smoke for 60 days. Blood samples were collected to evaluate the levels of cotinine and alkaline phosphatase. Both tibias were dissected and weighed; the lengths were measured, and the bones were then stored in a freezer for analysis of bone mineral content and mechanical resistance (maximal load and stiffness). RESULTS: Exposure of rats to tobacco smoke significantly compromised bone health, suggesting that the harmful effects may be time dependent. Harmful effects on bone growth were detected and were more pronounced at 60-day follow-ups with a 41.8% reduction in alkaline phosphatase levels (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2017-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/14255810.6061/clinics/2017(12)11Clinics; Vol. 72 No. 12 (2017); 785-789Clinics; v. 72 n. 12 (2017); 785-789Clinics; Vol. 72 Núm. 12 (2017); 785-7891980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/142558/137591Copyright (c) 2018 Clinicsinfo:eu-repo/semantics/openAccessRosa, Rodrigo CésarPereira, Sângela CunhaCardoso, Fabrizio Antônio GomideCaetano, Abadio GonçalvesSantiago, Hildemberg Agostinho Rocha deVolpon, José Batista2018-01-23T10:06:01Zoai:revistas.usp.br:article/142558Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2018-01-23T10:06:01Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Second hand tobacco smoke adversely affects the bone of immature rats |
title |
Second hand tobacco smoke adversely affects the bone of immature rats |
spellingShingle |
Second hand tobacco smoke adversely affects the bone of immature rats Rosa, Rodrigo César Smoking Bone Development Bone Density Tibia Rats |
title_short |
Second hand tobacco smoke adversely affects the bone of immature rats |
title_full |
Second hand tobacco smoke adversely affects the bone of immature rats |
title_fullStr |
Second hand tobacco smoke adversely affects the bone of immature rats |
title_full_unstemmed |
Second hand tobacco smoke adversely affects the bone of immature rats |
title_sort |
Second hand tobacco smoke adversely affects the bone of immature rats |
author |
Rosa, Rodrigo César |
author_facet |
Rosa, Rodrigo César Pereira, Sângela Cunha Cardoso, Fabrizio Antônio Gomide Caetano, Abadio Gonçalves Santiago, Hildemberg Agostinho Rocha de Volpon, José Batista |
author_role |
author |
author2 |
Pereira, Sângela Cunha Cardoso, Fabrizio Antônio Gomide Caetano, Abadio Gonçalves Santiago, Hildemberg Agostinho Rocha de Volpon, José Batista |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Rosa, Rodrigo César Pereira, Sângela Cunha Cardoso, Fabrizio Antônio Gomide Caetano, Abadio Gonçalves Santiago, Hildemberg Agostinho Rocha de Volpon, José Batista |
dc.subject.por.fl_str_mv |
Smoking Bone Development Bone Density Tibia Rats |
topic |
Smoking Bone Development Bone Density Tibia Rats |
description |
OBJECTIVES: To evaluate the influence of secondhand cigarette smoke exposure on longitudinal growth of the tibia of growing rats and some parameters of bone quality. METHODS: Forty female rats were randomly divided into four groups: control: rats were sham exposed; 30 days: rats were exposed to tobacco smoke for 30 days; 45 days: rats were exposed to tobacco smoke for 45 days; and 60 days: rats were exposed to tobacco smoke for 60 days. Blood samples were collected to evaluate the levels of cotinine and alkaline phosphatase. Both tibias were dissected and weighed; the lengths were measured, and the bones were then stored in a freezer for analysis of bone mineral content and mechanical resistance (maximal load and stiffness). RESULTS: Exposure of rats to tobacco smoke significantly compromised bone health, suggesting that the harmful effects may be time dependent. Harmful effects on bone growth were detected and were more pronounced at 60-day follow-ups with a 41.8% reduction in alkaline phosphatase levels (p |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/142558 10.6061/clinics/2017(12)11 |
url |
https://www.revistas.usp.br/clinics/article/view/142558 |
identifier_str_mv |
10.6061/clinics/2017(12)11 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/142558/137591 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 72 No. 12 (2017); 785-789 Clinics; v. 72 n. 12 (2017); 785-789 Clinics; Vol. 72 Núm. 12 (2017); 785-789 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222763642781696 |