Association between bile acid metabolism and bone mineral density in postmenopausal women
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/168243 |
Resumo: | OBJECTIVES: Previous studies have not shown any correlation between bile acid metabolism and bone mineral density (BMD) in women with postmenopausal osteoporosis. Thus, the current study evaluated the association between bile acid levels as well as BMD and bone turnover marker levels in this group of women. METHODS: This single-center cross-sectional study included 150 postmenopausal Chinese women. According to BMD, the participants were divided into three groups: osteoporosis group, osteopenia group, and healthy control group. Serum bile acid, fibroblast growth factor 19 (FGF19), and bone turnover biomarker levels were assessed. Moreover, the concentrations of parathyroid hormone, 25-hydroxy vitamin D [25(OH)D], procollagen type I N-peptide (P1NP), and beta-CrossLaps of type I collagen containing cross-linked C-terminal telopeptide (bCTX) were evaluated. The BMD of the lumbar spine and proximal femur were examined via dual-energy X-ray absorptiometry. RESULTS: The serum total bile acid levels in the osteoporosis and osteopenia groups (5.28±1.56 and 5.31±1.56 umol/L, respectively) were significantly lower than that in the healthy control group (6.33±2.04 umol/L; p=0.002 and 0.018, respectively). Serum bile acid level was positively associated with the BMD of the lumbar spine, femoral neck, and total hip. However, it negatively correlated with b-CTX concentration. Moreover, no correlation was observed between bile acid and P1NP levels, and the levels of the other biomarkers that were measured did not differ between the groups. CONCLUSION: Serum bile acid was positively correlated with BMD and negatively correlated with bone turnover biomarkers reflecting bone absorption in postmenopausal women. Thus, bile acid may play an important role in bone metabolism. |
id |
USP-19_2bce1a70793300da42dc971b56e0c891 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/168243 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
Association between bile acid metabolism and bone mineral density in postmenopausal womenPostmenopausal OsteoporosisBile Acid MetabolismFGF19OBJECTIVES: Previous studies have not shown any correlation between bile acid metabolism and bone mineral density (BMD) in women with postmenopausal osteoporosis. Thus, the current study evaluated the association between bile acid levels as well as BMD and bone turnover marker levels in this group of women. METHODS: This single-center cross-sectional study included 150 postmenopausal Chinese women. According to BMD, the participants were divided into three groups: osteoporosis group, osteopenia group, and healthy control group. Serum bile acid, fibroblast growth factor 19 (FGF19), and bone turnover biomarker levels were assessed. Moreover, the concentrations of parathyroid hormone, 25-hydroxy vitamin D [25(OH)D], procollagen type I N-peptide (P1NP), and beta-CrossLaps of type I collagen containing cross-linked C-terminal telopeptide (bCTX) were evaluated. The BMD of the lumbar spine and proximal femur were examined via dual-energy X-ray absorptiometry. RESULTS: The serum total bile acid levels in the osteoporosis and osteopenia groups (5.28±1.56 and 5.31±1.56 umol/L, respectively) were significantly lower than that in the healthy control group (6.33±2.04 umol/L; p=0.002 and 0.018, respectively). Serum bile acid level was positively associated with the BMD of the lumbar spine, femoral neck, and total hip. However, it negatively correlated with b-CTX concentration. Moreover, no correlation was observed between bile acid and P1NP levels, and the levels of the other biomarkers that were measured did not differ between the groups. CONCLUSION: Serum bile acid was positively correlated with BMD and negatively correlated with bone turnover biomarkers reflecting bone absorption in postmenopausal women. Thus, bile acid may play an important role in bone metabolism.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2020-03-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/16824310.6061/clinics/2020/e1486Clinics; Vol. 75 (2020); e1486Clinics; v. 75 (2020); e1486Clinics; Vol. 75 (2020); e14861980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/168243/160054https://www.revistas.usp.br/clinics/article/view/168243/160055Copyright (c) 2020 Clinicsinfo:eu-repo/semantics/openAccessZhao, Yu-XiaoSong, Yu-WenZhang, LiangZheng, Feng-JieWang, Xue-MengZhuang, Xiang-HuaWu, FeiLiu, Jian2020-03-30T17:08:35Zoai:revistas.usp.br:article/168243Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2020-03-30T17:08:35Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Association between bile acid metabolism and bone mineral density in postmenopausal women |
title |
Association between bile acid metabolism and bone mineral density in postmenopausal women |
spellingShingle |
Association between bile acid metabolism and bone mineral density in postmenopausal women Zhao, Yu-Xiao Postmenopausal Osteoporosis Bile Acid Metabolism FGF19 |
title_short |
Association between bile acid metabolism and bone mineral density in postmenopausal women |
title_full |
Association between bile acid metabolism and bone mineral density in postmenopausal women |
title_fullStr |
Association between bile acid metabolism and bone mineral density in postmenopausal women |
title_full_unstemmed |
Association between bile acid metabolism and bone mineral density in postmenopausal women |
title_sort |
Association between bile acid metabolism and bone mineral density in postmenopausal women |
author |
Zhao, Yu-Xiao |
author_facet |
Zhao, Yu-Xiao Song, Yu-Wen Zhang, Liang Zheng, Feng-Jie Wang, Xue-Meng Zhuang, Xiang-Hua Wu, Fei Liu, Jian |
author_role |
author |
author2 |
Song, Yu-Wen Zhang, Liang Zheng, Feng-Jie Wang, Xue-Meng Zhuang, Xiang-Hua Wu, Fei Liu, Jian |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Zhao, Yu-Xiao Song, Yu-Wen Zhang, Liang Zheng, Feng-Jie Wang, Xue-Meng Zhuang, Xiang-Hua Wu, Fei Liu, Jian |
dc.subject.por.fl_str_mv |
Postmenopausal Osteoporosis Bile Acid Metabolism FGF19 |
topic |
Postmenopausal Osteoporosis Bile Acid Metabolism FGF19 |
description |
OBJECTIVES: Previous studies have not shown any correlation between bile acid metabolism and bone mineral density (BMD) in women with postmenopausal osteoporosis. Thus, the current study evaluated the association between bile acid levels as well as BMD and bone turnover marker levels in this group of women. METHODS: This single-center cross-sectional study included 150 postmenopausal Chinese women. According to BMD, the participants were divided into three groups: osteoporosis group, osteopenia group, and healthy control group. Serum bile acid, fibroblast growth factor 19 (FGF19), and bone turnover biomarker levels were assessed. Moreover, the concentrations of parathyroid hormone, 25-hydroxy vitamin D [25(OH)D], procollagen type I N-peptide (P1NP), and beta-CrossLaps of type I collagen containing cross-linked C-terminal telopeptide (bCTX) were evaluated. The BMD of the lumbar spine and proximal femur were examined via dual-energy X-ray absorptiometry. RESULTS: The serum total bile acid levels in the osteoporosis and osteopenia groups (5.28±1.56 and 5.31±1.56 umol/L, respectively) were significantly lower than that in the healthy control group (6.33±2.04 umol/L; p=0.002 and 0.018, respectively). Serum bile acid level was positively associated with the BMD of the lumbar spine, femoral neck, and total hip. However, it negatively correlated with b-CTX concentration. Moreover, no correlation was observed between bile acid and P1NP levels, and the levels of the other biomarkers that were measured did not differ between the groups. CONCLUSION: Serum bile acid was positively correlated with BMD and negatively correlated with bone turnover biomarkers reflecting bone absorption in postmenopausal women. Thus, bile acid may play an important role in bone metabolism. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/168243 10.6061/clinics/2020/e1486 |
url |
https://www.revistas.usp.br/clinics/article/view/168243 |
identifier_str_mv |
10.6061/clinics/2020/e1486 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/168243/160054 https://www.revistas.usp.br/clinics/article/view/168243/160055 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 75 (2020); e1486 Clinics; v. 75 (2020); e1486 Clinics; Vol. 75 (2020); e1486 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222764719669248 |