The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/158004 |
Resumo: | The very large economic and social burdens of fracture-related complications make rapid fracture healing a major public health goal. The role of parathyroid hormone (PTH) in treating osteoporosis is generally accepted, but the effect of PTH on fracture healing is controversial. This meta-analysis was designed to investigate the efficacy and safety of PTH in fracture healing. The EMBASE, PubMed, and Cochrane Library databases were systematically searched from the inception dates to April 26, 2018. The primary randomized clinical trials comparing PTH treatment for fracture healing with placebo or no treatment were identified. We did not gain additional information by contacting the authors of the primary studies. Two reviewers independently extracted the data and evaluated study quality. This meta-analysis was executed to determine the odds ratio, mean difference, standardized mean difference, and 95% confidence intervals with random-effects models. In total, 8 randomized trials including 524 patients met the inclusion criteria. There were significant differences in fracture healing time, pain relief and function improvement. There were no significant differences in the fracture healing rate or adverse events, including light-headedness, hypercalcemia, nausea, sweating and headache, except for slight bruising at the injection site. We determined that the effectiveness and safety of PTH in fracture healing is reasonably well established and credible. |
id |
USP-19_2d86015653672ac0b0abc0a24c4ea56b |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/158004 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysisParathyroid HormonePTHTeriparatideFracture HealingThe very large economic and social burdens of fracture-related complications make rapid fracture healing a major public health goal. The role of parathyroid hormone (PTH) in treating osteoporosis is generally accepted, but the effect of PTH on fracture healing is controversial. This meta-analysis was designed to investigate the efficacy and safety of PTH in fracture healing. The EMBASE, PubMed, and Cochrane Library databases were systematically searched from the inception dates to April 26, 2018. The primary randomized clinical trials comparing PTH treatment for fracture healing with placebo or no treatment were identified. We did not gain additional information by contacting the authors of the primary studies. Two reviewers independently extracted the data and evaluated study quality. This meta-analysis was executed to determine the odds ratio, mean difference, standardized mean difference, and 95% confidence intervals with random-effects models. In total, 8 randomized trials including 524 patients met the inclusion criteria. There were significant differences in fracture healing time, pain relief and function improvement. There were no significant differences in the fracture healing rate or adverse events, including light-headedness, hypercalcemia, nausea, sweating and headache, except for slight bruising at the injection site. We determined that the effectiveness and safety of PTH in fracture healing is reasonably well established and credible.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-05-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/15800410.6061/clinics/2019/e800Clinics; Vol. 74 (2019); e800Clinics; v. 74 (2019); e800Clinics; Vol. 74 (2019); e8001980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/158004/153253https://www.revistas.usp.br/clinics/article/view/158004/153569Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessHong, HaoSong, TingLiu, YangLi, JunJiang, QilongSong, QizhiDeng, Zhongliang2019-08-12T16:37:17Zoai:revistas.usp.br:article/158004Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-08-12T16:37:17Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis |
title |
The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis |
spellingShingle |
The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis Hong, Hao Parathyroid Hormone PTH Teriparatide Fracture Healing |
title_short |
The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis |
title_full |
The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis |
title_fullStr |
The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis |
title_full_unstemmed |
The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis |
title_sort |
The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis |
author |
Hong, Hao |
author_facet |
Hong, Hao Song, Ting Liu, Yang Li, Jun Jiang, Qilong Song, Qizhi Deng, Zhongliang |
author_role |
author |
author2 |
Song, Ting Liu, Yang Li, Jun Jiang, Qilong Song, Qizhi Deng, Zhongliang |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Hong, Hao Song, Ting Liu, Yang Li, Jun Jiang, Qilong Song, Qizhi Deng, Zhongliang |
dc.subject.por.fl_str_mv |
Parathyroid Hormone PTH Teriparatide Fracture Healing |
topic |
Parathyroid Hormone PTH Teriparatide Fracture Healing |
description |
The very large economic and social burdens of fracture-related complications make rapid fracture healing a major public health goal. The role of parathyroid hormone (PTH) in treating osteoporosis is generally accepted, but the effect of PTH on fracture healing is controversial. This meta-analysis was designed to investigate the efficacy and safety of PTH in fracture healing. The EMBASE, PubMed, and Cochrane Library databases were systematically searched from the inception dates to April 26, 2018. The primary randomized clinical trials comparing PTH treatment for fracture healing with placebo or no treatment were identified. We did not gain additional information by contacting the authors of the primary studies. Two reviewers independently extracted the data and evaluated study quality. This meta-analysis was executed to determine the odds ratio, mean difference, standardized mean difference, and 95% confidence intervals with random-effects models. In total, 8 randomized trials including 524 patients met the inclusion criteria. There were significant differences in fracture healing time, pain relief and function improvement. There were no significant differences in the fracture healing rate or adverse events, including light-headedness, hypercalcemia, nausea, sweating and headache, except for slight bruising at the injection site. We determined that the effectiveness and safety of PTH in fracture healing is reasonably well established and credible. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-05-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/158004 10.6061/clinics/2019/e800 |
url |
https://www.revistas.usp.br/clinics/article/view/158004 |
identifier_str_mv |
10.6061/clinics/2019/e800 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/158004/153253 https://www.revistas.usp.br/clinics/article/view/158004/153569 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 74 (2019); e800 Clinics; v. 74 (2019); e800 Clinics; Vol. 74 (2019); e800 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222764149243904 |