Evaluation of systemic inflammation in patients being weaned from mechanical ventilation
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/154636 |
Resumo: | OBJECTIVES: The aim of this study was to evaluate systemic inflammatory factors and their relation to success or failure in a spontaneous ventilation test. METHODS: This cross-sectional study included a sample of 54 adult patients. Demographic data and clinical parameters were collected, and blood samples were collected in the first minute of the spontaneous ventilation test to evaluate interleukin (IL)-1b, IL-6, IL-8, and IL-10, tumour necrosis factor alpha (TNFa) and C-reactive protein. RESULTS: Patients who experienced extubation failure presented a lower rapid shallow breathing index than those who passed, and these patients also showed a significant increase in C-reactive protein 48 hours after extubation. We observed, moreover, that each unit increase in inflammatory factors led to a higher risk of spontaneous ventilation test failure, with a risk of 2.27 (1.001 – 4.60, p=0.049) for TNFa, 2.23 (1.06 – 6.54, p=0.037) for IL-6, 2.66 (1.06 – 6.70, p=0.037) for IL-8 and 2.08 (1.01 – 4.31, p=0.04) for IL-10, and the rapid shallow breathing index was correlated with IL-1 (r=-0.51, p=0.04). CONCLUSIONS: C-reactive protein is increased in patients who fail the spontaneous ventilation test, and increased ILs are associated with a greater prevalence of failure in this process; the rapid shallow breathing index may not be effective in patients who present systemic inflammation. |
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Clinics |
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Evaluation of systemic inflammation in patients being weaned from mechanical ventilationMechanical VentilationWeaningInflammatory FactorsOBJECTIVES: The aim of this study was to evaluate systemic inflammatory factors and their relation to success or failure in a spontaneous ventilation test. METHODS: This cross-sectional study included a sample of 54 adult patients. Demographic data and clinical parameters were collected, and blood samples were collected in the first minute of the spontaneous ventilation test to evaluate interleukin (IL)-1b, IL-6, IL-8, and IL-10, tumour necrosis factor alpha (TNFa) and C-reactive protein. RESULTS: Patients who experienced extubation failure presented a lower rapid shallow breathing index than those who passed, and these patients also showed a significant increase in C-reactive protein 48 hours after extubation. We observed, moreover, that each unit increase in inflammatory factors led to a higher risk of spontaneous ventilation test failure, with a risk of 2.27 (1.001 – 4.60, p=0.049) for TNFa, 2.23 (1.06 – 6.54, p=0.037) for IL-6, 2.66 (1.06 – 6.70, p=0.037) for IL-8 and 2.08 (1.01 – 4.31, p=0.04) for IL-10, and the rapid shallow breathing index was correlated with IL-1 (r=-0.51, p=0.04). CONCLUSIONS: C-reactive protein is increased in patients who fail the spontaneous ventilation test, and increased ILs are associated with a greater prevalence of failure in this process; the rapid shallow breathing index may not be effective in patients who present systemic inflammation.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-02-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/15463610.6061/clinics/2018/e256Clinics; Vol. 73 (2018); e256Clinics; v. 73 (2018); e256Clinics; Vol. 73 (2018); e2561980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/154636/150735Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessForgiarini, Soraia Genebra IbrahimRosa, Darlan Pase daForgiarini, Luiz FelipeTeixeira, CassianoAndrade, Cristiano FeijóForgiarini Junior, Luiz AlbertoFelix, Elaine AparecidaFriedman, Gilberto2019-05-14T11:48:50Zoai:revistas.usp.br:article/154636Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-05-14T11:48:50Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Evaluation of systemic inflammation in patients being weaned from mechanical ventilation |
title |
Evaluation of systemic inflammation in patients being weaned from mechanical ventilation |
spellingShingle |
Evaluation of systemic inflammation in patients being weaned from mechanical ventilation Forgiarini, Soraia Genebra Ibrahim Mechanical Ventilation Weaning Inflammatory Factors |
title_short |
Evaluation of systemic inflammation in patients being weaned from mechanical ventilation |
title_full |
Evaluation of systemic inflammation in patients being weaned from mechanical ventilation |
title_fullStr |
Evaluation of systemic inflammation in patients being weaned from mechanical ventilation |
title_full_unstemmed |
Evaluation of systemic inflammation in patients being weaned from mechanical ventilation |
title_sort |
Evaluation of systemic inflammation in patients being weaned from mechanical ventilation |
author |
Forgiarini, Soraia Genebra Ibrahim |
author_facet |
Forgiarini, Soraia Genebra Ibrahim Rosa, Darlan Pase da Forgiarini, Luiz Felipe Teixeira, Cassiano Andrade, Cristiano Feijó Forgiarini Junior, Luiz Alberto Felix, Elaine Aparecida Friedman, Gilberto |
author_role |
author |
author2 |
Rosa, Darlan Pase da Forgiarini, Luiz Felipe Teixeira, Cassiano Andrade, Cristiano Feijó Forgiarini Junior, Luiz Alberto Felix, Elaine Aparecida Friedman, Gilberto |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Forgiarini, Soraia Genebra Ibrahim Rosa, Darlan Pase da Forgiarini, Luiz Felipe Teixeira, Cassiano Andrade, Cristiano Feijó Forgiarini Junior, Luiz Alberto Felix, Elaine Aparecida Friedman, Gilberto |
dc.subject.por.fl_str_mv |
Mechanical Ventilation Weaning Inflammatory Factors |
topic |
Mechanical Ventilation Weaning Inflammatory Factors |
description |
OBJECTIVES: The aim of this study was to evaluate systemic inflammatory factors and their relation to success or failure in a spontaneous ventilation test. METHODS: This cross-sectional study included a sample of 54 adult patients. Demographic data and clinical parameters were collected, and blood samples were collected in the first minute of the spontaneous ventilation test to evaluate interleukin (IL)-1b, IL-6, IL-8, and IL-10, tumour necrosis factor alpha (TNFa) and C-reactive protein. RESULTS: Patients who experienced extubation failure presented a lower rapid shallow breathing index than those who passed, and these patients also showed a significant increase in C-reactive protein 48 hours after extubation. We observed, moreover, that each unit increase in inflammatory factors led to a higher risk of spontaneous ventilation test failure, with a risk of 2.27 (1.001 – 4.60, p=0.049) for TNFa, 2.23 (1.06 – 6.54, p=0.037) for IL-6, 2.66 (1.06 – 6.70, p=0.037) for IL-8 and 2.08 (1.01 – 4.31, p=0.04) for IL-10, and the rapid shallow breathing index was correlated with IL-1 (r=-0.51, p=0.04). CONCLUSIONS: C-reactive protein is increased in patients who fail the spontaneous ventilation test, and increased ILs are associated with a greater prevalence of failure in this process; the rapid shallow breathing index may not be effective in patients who present systemic inflammation. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02-11 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/154636 10.6061/clinics/2018/e256 |
url |
https://www.revistas.usp.br/clinics/article/view/154636 |
identifier_str_mv |
10.6061/clinics/2018/e256 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/154636/150735 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 73 (2018); e256 Clinics; v. 73 (2018); e256 Clinics; Vol. 73 (2018); e256 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222763711987712 |