Evaluation of systemic inflammation in patients being weaned from mechanical ventilation

Detalhes bibliográficos
Autor(a) principal: Forgiarini, Soraia Genebra Ibrahim
Data de Publicação: 2019
Outros Autores: Rosa, Darlan Pase da, Forgiarini, Luiz Felipe, Teixeira, Cassiano, Andrade, Cristiano Feijó, Forgiarini Junior, Luiz Alberto, Felix, Elaine Aparecida, Friedman, Gilberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/154636
Resumo: OBJECTIVES: The aim of this study was to evaluate systemic inflammatory factors and their relation to success or failure in a spontaneous ventilation test. METHODS: This cross-sectional study included a sample of 54 adult patients. Demographic data and clinical parameters were collected, and blood samples were collected in the first minute of the spontaneous ventilation test to evaluate interleukin (IL)-1b, IL-6, IL-8, and IL-10, tumour necrosis factor alpha (TNFa) and C-reactive protein. RESULTS: Patients who experienced extubation failure presented a lower rapid shallow breathing index than those who passed, and these patients also showed a significant increase in C-reactive protein 48 hours after extubation. We observed, moreover, that each unit increase in inflammatory factors led to a higher risk of spontaneous ventilation test failure, with a risk of 2.27 (1.001 – 4.60, p=0.049) for TNFa, 2.23 (1.06 – 6.54, p=0.037) for IL-6, 2.66 (1.06 – 6.70, p=0.037) for IL-8 and 2.08 (1.01 – 4.31, p=0.04) for IL-10, and the rapid shallow breathing index was correlated with IL-1 (r=-0.51, p=0.04). CONCLUSIONS: C-reactive protein is increased in patients who fail the spontaneous ventilation test, and increased ILs are associated with a greater prevalence of failure in this process; the rapid shallow breathing index may not be effective in patients who present systemic inflammation.
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spelling Evaluation of systemic inflammation in patients being weaned from mechanical ventilationMechanical VentilationWeaningInflammatory FactorsOBJECTIVES: The aim of this study was to evaluate systemic inflammatory factors and their relation to success or failure in a spontaneous ventilation test. METHODS: This cross-sectional study included a sample of 54 adult patients. Demographic data and clinical parameters were collected, and blood samples were collected in the first minute of the spontaneous ventilation test to evaluate interleukin (IL)-1b, IL-6, IL-8, and IL-10, tumour necrosis factor alpha (TNFa) and C-reactive protein. RESULTS: Patients who experienced extubation failure presented a lower rapid shallow breathing index than those who passed, and these patients also showed a significant increase in C-reactive protein 48 hours after extubation. We observed, moreover, that each unit increase in inflammatory factors led to a higher risk of spontaneous ventilation test failure, with a risk of 2.27 (1.001 – 4.60, p=0.049) for TNFa, 2.23 (1.06 – 6.54, p=0.037) for IL-6, 2.66 (1.06 – 6.70, p=0.037) for IL-8 and 2.08 (1.01 – 4.31, p=0.04) for IL-10, and the rapid shallow breathing index was correlated with IL-1 (r=-0.51, p=0.04). CONCLUSIONS: C-reactive protein is increased in patients who fail the spontaneous ventilation test, and increased ILs are associated with a greater prevalence of failure in this process; the rapid shallow breathing index may not be effective in patients who present systemic inflammation.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-02-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/15463610.6061/clinics/2018/e256Clinics; Vol. 73 (2018); e256Clinics; v. 73 (2018); e256Clinics; Vol. 73 (2018); e2561980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/154636/150735Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessForgiarini, Soraia Genebra IbrahimRosa, Darlan Pase daForgiarini, Luiz FelipeTeixeira, CassianoAndrade, Cristiano FeijóForgiarini Junior, Luiz AlbertoFelix, Elaine AparecidaFriedman, Gilberto2019-05-14T11:48:50Zoai:revistas.usp.br:article/154636Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-05-14T11:48:50Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Evaluation of systemic inflammation in patients being weaned from mechanical ventilation
title Evaluation of systemic inflammation in patients being weaned from mechanical ventilation
spellingShingle Evaluation of systemic inflammation in patients being weaned from mechanical ventilation
Forgiarini, Soraia Genebra Ibrahim
Mechanical Ventilation
Weaning
Inflammatory Factors
title_short Evaluation of systemic inflammation in patients being weaned from mechanical ventilation
title_full Evaluation of systemic inflammation in patients being weaned from mechanical ventilation
title_fullStr Evaluation of systemic inflammation in patients being weaned from mechanical ventilation
title_full_unstemmed Evaluation of systemic inflammation in patients being weaned from mechanical ventilation
title_sort Evaluation of systemic inflammation in patients being weaned from mechanical ventilation
author Forgiarini, Soraia Genebra Ibrahim
author_facet Forgiarini, Soraia Genebra Ibrahim
Rosa, Darlan Pase da
Forgiarini, Luiz Felipe
Teixeira, Cassiano
Andrade, Cristiano Feijó
Forgiarini Junior, Luiz Alberto
Felix, Elaine Aparecida
Friedman, Gilberto
author_role author
author2 Rosa, Darlan Pase da
Forgiarini, Luiz Felipe
Teixeira, Cassiano
Andrade, Cristiano Feijó
Forgiarini Junior, Luiz Alberto
Felix, Elaine Aparecida
Friedman, Gilberto
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Forgiarini, Soraia Genebra Ibrahim
Rosa, Darlan Pase da
Forgiarini, Luiz Felipe
Teixeira, Cassiano
Andrade, Cristiano Feijó
Forgiarini Junior, Luiz Alberto
Felix, Elaine Aparecida
Friedman, Gilberto
dc.subject.por.fl_str_mv Mechanical Ventilation
Weaning
Inflammatory Factors
topic Mechanical Ventilation
Weaning
Inflammatory Factors
description OBJECTIVES: The aim of this study was to evaluate systemic inflammatory factors and their relation to success or failure in a spontaneous ventilation test. METHODS: This cross-sectional study included a sample of 54 adult patients. Demographic data and clinical parameters were collected, and blood samples were collected in the first minute of the spontaneous ventilation test to evaluate interleukin (IL)-1b, IL-6, IL-8, and IL-10, tumour necrosis factor alpha (TNFa) and C-reactive protein. RESULTS: Patients who experienced extubation failure presented a lower rapid shallow breathing index than those who passed, and these patients also showed a significant increase in C-reactive protein 48 hours after extubation. We observed, moreover, that each unit increase in inflammatory factors led to a higher risk of spontaneous ventilation test failure, with a risk of 2.27 (1.001 – 4.60, p=0.049) for TNFa, 2.23 (1.06 – 6.54, p=0.037) for IL-6, 2.66 (1.06 – 6.70, p=0.037) for IL-8 and 2.08 (1.01 – 4.31, p=0.04) for IL-10, and the rapid shallow breathing index was correlated with IL-1 (r=-0.51, p=0.04). CONCLUSIONS: C-reactive protein is increased in patients who fail the spontaneous ventilation test, and increased ILs are associated with a greater prevalence of failure in this process; the rapid shallow breathing index may not be effective in patients who present systemic inflammation.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-11
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/154636
10.6061/clinics/2018/e256
url https://www.revistas.usp.br/clinics/article/view/154636
identifier_str_mv 10.6061/clinics/2018/e256
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/154636/150735
dc.rights.driver.fl_str_mv Copyright (c) 2019 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 73 (2018); e256
Clinics; v. 73 (2018); e256
Clinics; Vol. 73 (2018); e256
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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