Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/18382 |
Resumo: | INTRODUCTION: Oral β-blockers improve the prognosis of patients with acute myocardial infarction, while atrial fibrillation worsens the prognosis of this population. The reduction of atrial fibrillation incidence in patients treated with β-blockers could at least in part explain the benefits of this drug. OBJECTIVE: To investigate the effect of β-blockers on the incidence of atrial fibrillation in patients with acute myocardial infarction. METHODS: We analyzed 1401 patients with acute myocardial infarction and evaluated the occurrence or absence of atrial fibrillation, the use of oral β-blockers and mortality during the first 24 hours. RESULTS: a) The use of β-blockers was inversely correlated with the presence of atrial fibrillation (ρ = 0.004; OR = 0.54). b) Correlations with mortality were as follows: 31.5% in patients with atrial fibrillation, 9.2% in those without atrial fibrillation (ρ < 0.001; Odds Ratio = 4.52), and 17.5% in patients not treated with β-blockers and 6.7% in those who received the drug (ρ < 0.001; OR = 0.34). c) Adjusted Models: The presence of atrial fibrillation was independently correlated with mortality (OR = 2.48, ρ = 0.002). The use of β-blockers was inversely and independently correlated with mortality (OR = 0.53; ρ = 0.002). The patients who used β-blockers showed a lower risk of atrial fibrillation (OR = 0.59; ρ = 0.029) in the adjusted model. CONCLUSION: The presence of atrial fibrillation and the absence of oral β-blockers increased in-hospital mortality in patients with acute myocardial infarction. Oral β-blockers reduced the incidence of atrial fibrillation, which might be at least partially responsible for the drug's benefit. |
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Clinics |
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Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction Acute myocardial infarctionβ-blockersAtrial fibrillationMortalityArrhythmias INTRODUCTION: Oral β-blockers improve the prognosis of patients with acute myocardial infarction, while atrial fibrillation worsens the prognosis of this population. The reduction of atrial fibrillation incidence in patients treated with β-blockers could at least in part explain the benefits of this drug. OBJECTIVE: To investigate the effect of β-blockers on the incidence of atrial fibrillation in patients with acute myocardial infarction. METHODS: We analyzed 1401 patients with acute myocardial infarction and evaluated the occurrence or absence of atrial fibrillation, the use of oral β-blockers and mortality during the first 24 hours. RESULTS: a) The use of β-blockers was inversely correlated with the presence of atrial fibrillation (ρ = 0.004; OR = 0.54). b) Correlations with mortality were as follows: 31.5% in patients with atrial fibrillation, 9.2% in those without atrial fibrillation (ρ < 0.001; Odds Ratio = 4.52), and 17.5% in patients not treated with β-blockers and 6.7% in those who received the drug (ρ < 0.001; OR = 0.34). c) Adjusted Models: The presence of atrial fibrillation was independently correlated with mortality (OR = 2.48, ρ = 0.002). The use of β-blockers was inversely and independently correlated with mortality (OR = 0.53; ρ = 0.002). The patients who used β-blockers showed a lower risk of atrial fibrillation (OR = 0.59; ρ = 0.029) in the adjusted model. CONCLUSION: The presence of atrial fibrillation and the absence of oral β-blockers increased in-hospital mortality in patients with acute myocardial infarction. Oral β-blockers reduced the incidence of atrial fibrillation, which might be at least partially responsible for the drug's benefit. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1838210.1590/S1807-59322010000300005Clinics; Vol. 65 No. 3 (2010); 265-270 Clinics; v. 65 n. 3 (2010); 265-270 Clinics; Vol. 65 Núm. 3 (2010); 265-270 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18382/20445Pesaro, Antonio EduardoSoeiro, Alexandre de MatosSerrano, Carlos VicenteGiraldez, Roberto RochaLadeira, Renata TeixeiraNicolau, José Carlosinfo:eu-repo/semantics/openAccess2012-05-23T11:18:48Zoai:revistas.usp.br:article/18382Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:18:48Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
title |
Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
spellingShingle |
Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction Pesaro, Antonio Eduardo Acute myocardial infarction β -blockers Atrial fibrillation Mortality Arrhythmias |
title_short |
Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
title_full |
Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
title_fullStr |
Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
title_full_unstemmed |
Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
title_sort |
Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
author |
Pesaro, Antonio Eduardo |
author_facet |
Pesaro, Antonio Eduardo Soeiro, Alexandre de Matos Serrano, Carlos Vicente Giraldez, Roberto Rocha Ladeira, Renata Teixeira Nicolau, José Carlos |
author_role |
author |
author2 |
Soeiro, Alexandre de Matos Serrano, Carlos Vicente Giraldez, Roberto Rocha Ladeira, Renata Teixeira Nicolau, José Carlos |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pesaro, Antonio Eduardo Soeiro, Alexandre de Matos Serrano, Carlos Vicente Giraldez, Roberto Rocha Ladeira, Renata Teixeira Nicolau, José Carlos |
dc.subject.por.fl_str_mv |
Acute myocardial infarction β -blockers Atrial fibrillation Mortality Arrhythmias |
topic |
Acute myocardial infarction β -blockers Atrial fibrillation Mortality Arrhythmias |
description |
INTRODUCTION: Oral β-blockers improve the prognosis of patients with acute myocardial infarction, while atrial fibrillation worsens the prognosis of this population. The reduction of atrial fibrillation incidence in patients treated with β-blockers could at least in part explain the benefits of this drug. OBJECTIVE: To investigate the effect of β-blockers on the incidence of atrial fibrillation in patients with acute myocardial infarction. METHODS: We analyzed 1401 patients with acute myocardial infarction and evaluated the occurrence or absence of atrial fibrillation, the use of oral β-blockers and mortality during the first 24 hours. RESULTS: a) The use of β-blockers was inversely correlated with the presence of atrial fibrillation (ρ = 0.004; OR = 0.54). b) Correlations with mortality were as follows: 31.5% in patients with atrial fibrillation, 9.2% in those without atrial fibrillation (ρ < 0.001; Odds Ratio = 4.52), and 17.5% in patients not treated with β-blockers and 6.7% in those who received the drug (ρ < 0.001; OR = 0.34). c) Adjusted Models: The presence of atrial fibrillation was independently correlated with mortality (OR = 2.48, ρ = 0.002). The use of β-blockers was inversely and independently correlated with mortality (OR = 0.53; ρ = 0.002). The patients who used β-blockers showed a lower risk of atrial fibrillation (OR = 0.59; ρ = 0.029) in the adjusted model. CONCLUSION: The presence of atrial fibrillation and the absence of oral β-blockers increased in-hospital mortality in patients with acute myocardial infarction. Oral β-blockers reduced the incidence of atrial fibrillation, which might be at least partially responsible for the drug's benefit. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18382 10.1590/S1807-59322010000300005 |
url |
https://www.revistas.usp.br/clinics/article/view/18382 |
identifier_str_mv |
10.1590/S1807-59322010000300005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18382/20445 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 65 No. 3 (2010); 265-270 Clinics; v. 65 n. 3 (2010); 265-270 Clinics; Vol. 65 Núm. 3 (2010); 265-270 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222755244736512 |