Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient Little mice

• Autor(a) principal: Peroni, Cibele N.
• Data de Publicação: 2012
• Outros Autores: Hayashida, Cesar Y., Nascimento, Nancy, Longuini, Viviane C., Toledo, Rodrigo A., Bartolini, Paolo, Bowers, Cyril Y., Toledo, Sergio P.A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Clinics
• Texto Completo: https://www.revistas.usp.br/clinics/article/view/19665
• topic: Ghrelin; GH; GHRH-R; GHRP-2; Leptin; Little mouse

OBJECTIVE: To investigate a possible direct, growth hormone-releasing, hormone-independent action of a growth hormone secretagogue, GHRP-2, in pituitary somatotroph cells in the presence of inactive growth hormonereleasing hormone receptors. MATERIALS AND METHODS: The responses of serum growth hormone to acutely injected growth hormone-releasing P-2 in lit/litmice, which represent a model of GH deficiency arising frommutated growth hormone-releasing hormonereceptors, were compared to those observed in the heterozygous (lit/+) littermates and wild-type (+/+) C57BL/6J mice. RESULTS: After the administration of 10 mcg of growth hormone-releasing P-2 to lit/lit mice, a growth hormone release of 9.3±1.5 ng/ml was observed compared with 1.04±1.15 ng/ml in controls (p