Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/47933 |
Resumo: | OBJECTIVE: We present a prospective study of a microemulsion of cyclosporin to treat idiopathic nephrotic syndrome in ten children with normal renal function who presented cyclosporin trough levels between 50 and 150 ng/ml and achieved complete remission with cyclosporin. To compare the pharmacokinetic parameters of cyclosporin in idiopathic nephrotic syndrome during remission and relapse of the nephrotic state. METHOD: The pharmacokinetic profile of cyclosporin was evaluated with the 12-hour area under the timeconcentration curve (auc0-12) using seven time-point samples. This procedure was performed on each patient during remission and relapse with the same cyclosporin dose in mg/kg/day. The 12-hour area under the timeconcentration curve was calculated using the trapezoidal rule. All of the pharmacokinetic parameters and the resumed 4-hour area under the time-concentration curve were correlated with the 12-hour area under the timeconcentration curve. ClinicalTrials.gov:NCT01616446. RESULTS: There were no significant differences in any parameters of the pharmacokinetic of cyclosporin during remission and relapse, even when the data were normalized by dose. The best correlation with the 12-hour area under the time-concentration curve was the 4-hour area under the time-concentration curve on remission and relapse of the disease, followed by the 2-hour level after cyclosporin (c2) dosing in both disease states. CONCLUSIONS: These data indicate that the same parameters used for cyclosporin therapeutic monitoring estimated during the nephrotic state can also be used during remission. Larger controlled studies are needed to confirm these findings. |
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Clinics |
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Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndromeCyclosporin-ANephrotic SyndromeChildrenPharmacokineticsArea Under CurveOBJECTIVE: We present a prospective study of a microemulsion of cyclosporin to treat idiopathic nephrotic syndrome in ten children with normal renal function who presented cyclosporin trough levels between 50 and 150 ng/ml and achieved complete remission with cyclosporin. To compare the pharmacokinetic parameters of cyclosporin in idiopathic nephrotic syndrome during remission and relapse of the nephrotic state. METHOD: The pharmacokinetic profile of cyclosporin was evaluated with the 12-hour area under the timeconcentration curve (auc0-12) using seven time-point samples. This procedure was performed on each patient during remission and relapse with the same cyclosporin dose in mg/kg/day. The 12-hour area under the timeconcentration curve was calculated using the trapezoidal rule. All of the pharmacokinetic parameters and the resumed 4-hour area under the time-concentration curve were correlated with the 12-hour area under the timeconcentration curve. ClinicalTrials.gov:NCT01616446. RESULTS: There were no significant differences in any parameters of the pharmacokinetic of cyclosporin during remission and relapse, even when the data were normalized by dose. The best correlation with the 12-hour area under the time-concentration curve was the 4-hour area under the time-concentration curve on remission and relapse of the disease, followed by the 2-hour level after cyclosporin (c2) dosing in both disease states. CONCLUSIONS: These data indicate that the same parameters used for cyclosporin therapeutic monitoring estimated during the nephrotic state can also be used during remission. Larger controlled studies are needed to confirm these findings.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/4793310.6061/clinics/2012(10)12Clinics; Vol. 67 No. 10 (2012); 1197-1202Clinics; v. 67 n. 10 (2012); 1197-1202Clinics; Vol. 67 Núm. 10 (2012); 1197-12021980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/47933/51673Henriques, Luciana dos SantosMatos, Fabíola de MarcosVaisbich, Maria Helenainfo:eu-repo/semantics/openAccess2012-12-13T11:01:04Zoai:revistas.usp.br:article/47933Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-12-13T11:01:04Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome |
title |
Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome |
spellingShingle |
Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome Henriques, Luciana dos Santos Cyclosporin-A Nephrotic Syndrome Children Pharmacokinetics Area Under Curve |
title_short |
Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome |
title_full |
Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome |
title_fullStr |
Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome |
title_full_unstemmed |
Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome |
title_sort |
Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome |
author |
Henriques, Luciana dos Santos |
author_facet |
Henriques, Luciana dos Santos Matos, Fabíola de Marcos Vaisbich, Maria Helena |
author_role |
author |
author2 |
Matos, Fabíola de Marcos Vaisbich, Maria Helena |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Henriques, Luciana dos Santos Matos, Fabíola de Marcos Vaisbich, Maria Helena |
dc.subject.por.fl_str_mv |
Cyclosporin-A Nephrotic Syndrome Children Pharmacokinetics Area Under Curve |
topic |
Cyclosporin-A Nephrotic Syndrome Children Pharmacokinetics Area Under Curve |
description |
OBJECTIVE: We present a prospective study of a microemulsion of cyclosporin to treat idiopathic nephrotic syndrome in ten children with normal renal function who presented cyclosporin trough levels between 50 and 150 ng/ml and achieved complete remission with cyclosporin. To compare the pharmacokinetic parameters of cyclosporin in idiopathic nephrotic syndrome during remission and relapse of the nephrotic state. METHOD: The pharmacokinetic profile of cyclosporin was evaluated with the 12-hour area under the timeconcentration curve (auc0-12) using seven time-point samples. This procedure was performed on each patient during remission and relapse with the same cyclosporin dose in mg/kg/day. The 12-hour area under the timeconcentration curve was calculated using the trapezoidal rule. All of the pharmacokinetic parameters and the resumed 4-hour area under the time-concentration curve were correlated with the 12-hour area under the timeconcentration curve. ClinicalTrials.gov:NCT01616446. RESULTS: There were no significant differences in any parameters of the pharmacokinetic of cyclosporin during remission and relapse, even when the data were normalized by dose. The best correlation with the 12-hour area under the time-concentration curve was the 4-hour area under the time-concentration curve on remission and relapse of the disease, followed by the 2-hour level after cyclosporin (c2) dosing in both disease states. CONCLUSIONS: These data indicate that the same parameters used for cyclosporin therapeutic monitoring estimated during the nephrotic state can also be used during remission. Larger controlled studies are needed to confirm these findings. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/47933 10.6061/clinics/2012(10)12 |
url |
https://www.revistas.usp.br/clinics/article/view/47933 |
identifier_str_mv |
10.6061/clinics/2012(10)12 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/47933/51673 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 67 No. 10 (2012); 1197-1202 Clinics; v. 67 n. 10 (2012); 1197-1202 Clinics; Vol. 67 Núm. 10 (2012); 1197-1202 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222759172702208 |