Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/143350 |
Resumo: | OBJECTIVE: To assess the risk factors, incidence and severity of adverse drug reactions in in-patients. METHODS: This prospective study evaluated 472 patients treated at a teaching hospital in Brazil between 2010 and 2013 by five medical specialties: Internal Medicine, General Surgery, Geriatrics, Neurology, and Clinical Immunology and Allergy. The following variables were assessed: patient age, gender, comorbidities, family history of hypersensitivity, personal and family history of atopy, number of prescribed drugs before and during hospitalization, hospital diagnoses, days of hospitalization. The patients were visited every other day, and medical records were reviewed by the investigators to detect adverse drug reactions. RESULTS: There were a total of 94 adverse drug reactions in 75 patients. Most reactions were predictable and of moderate severity. The incidence of adverse drug reactions was 16.2%, and the incidence varied, according to the medical specialty; it was higher in Internal Medicine (30%). Antibiotics were the most commonly involved medication. Chronic renal failure, longer hospital stay, greater number of diagnoses and greater number of medications upon admission were risk factors. For each medication introduced during hospitalization, there was a 10% increase in the rate of adverse drug reaction. In the present study, the probability of observing an adverse drug reaction was 1 in 104 patients per day. CONCLUSIONS: Adverse drug reactions are frequent and potentially serious and should be better monitored in patients with chronic renal failure or prolonged hospitalization and especially in those on ‘polypharmacy’ regimens. The rational use of medications plays an important role in preventing adverse drug reactions. |
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Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized PatientsAdverse Drug ReactionsHypersensitivity ReactionsIn-patientsIncidenceRisk factorsOBJECTIVE: To assess the risk factors, incidence and severity of adverse drug reactions in in-patients. METHODS: This prospective study evaluated 472 patients treated at a teaching hospital in Brazil between 2010 and 2013 by five medical specialties: Internal Medicine, General Surgery, Geriatrics, Neurology, and Clinical Immunology and Allergy. The following variables were assessed: patient age, gender, comorbidities, family history of hypersensitivity, personal and family history of atopy, number of prescribed drugs before and during hospitalization, hospital diagnoses, days of hospitalization. The patients were visited every other day, and medical records were reviewed by the investigators to detect adverse drug reactions. RESULTS: There were a total of 94 adverse drug reactions in 75 patients. Most reactions were predictable and of moderate severity. The incidence of adverse drug reactions was 16.2%, and the incidence varied, according to the medical specialty; it was higher in Internal Medicine (30%). Antibiotics were the most commonly involved medication. Chronic renal failure, longer hospital stay, greater number of diagnoses and greater number of medications upon admission were risk factors. For each medication introduced during hospitalization, there was a 10% increase in the rate of adverse drug reaction. In the present study, the probability of observing an adverse drug reaction was 1 in 104 patients per day. CONCLUSIONS: Adverse drug reactions are frequent and potentially serious and should be better monitored in patients with chronic renal failure or prolonged hospitalization and especially in those on ‘polypharmacy’ regimens. The rational use of medications plays an important role in preventing adverse drug reactions.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/14335010.6061/clinics/2018/e185Clinics; Vol. 73 (2018); e185Clinics; v. 73 (2018); e185Clinics; Vol. 73 (2018); e1851980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/143350/138062Copyright (c) 2018 Clinicsinfo:eu-repo/semantics/openAccessRibeiro, Marisa RosimeireMotta, Antonio AbílioMarcondes-Fonseca, Luiz AugustoKalil-Filho, JorgeGiavina-Bianchi, Pedro2019-05-14T11:48:50Zoai:revistas.usp.br:article/143350Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-05-14T11:48:50Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients |
title |
Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients |
spellingShingle |
Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients Ribeiro, Marisa Rosimeire Adverse Drug Reactions Hypersensitivity Reactions In-patients Incidence Risk factors |
title_short |
Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients |
title_full |
Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients |
title_fullStr |
Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients |
title_full_unstemmed |
Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients |
title_sort |
Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients |
author |
Ribeiro, Marisa Rosimeire |
author_facet |
Ribeiro, Marisa Rosimeire Motta, Antonio Abílio Marcondes-Fonseca, Luiz Augusto Kalil-Filho, Jorge Giavina-Bianchi, Pedro |
author_role |
author |
author2 |
Motta, Antonio Abílio Marcondes-Fonseca, Luiz Augusto Kalil-Filho, Jorge Giavina-Bianchi, Pedro |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Ribeiro, Marisa Rosimeire Motta, Antonio Abílio Marcondes-Fonseca, Luiz Augusto Kalil-Filho, Jorge Giavina-Bianchi, Pedro |
dc.subject.por.fl_str_mv |
Adverse Drug Reactions Hypersensitivity Reactions In-patients Incidence Risk factors |
topic |
Adverse Drug Reactions Hypersensitivity Reactions In-patients Incidence Risk factors |
description |
OBJECTIVE: To assess the risk factors, incidence and severity of adverse drug reactions in in-patients. METHODS: This prospective study evaluated 472 patients treated at a teaching hospital in Brazil between 2010 and 2013 by five medical specialties: Internal Medicine, General Surgery, Geriatrics, Neurology, and Clinical Immunology and Allergy. The following variables were assessed: patient age, gender, comorbidities, family history of hypersensitivity, personal and family history of atopy, number of prescribed drugs before and during hospitalization, hospital diagnoses, days of hospitalization. The patients were visited every other day, and medical records were reviewed by the investigators to detect adverse drug reactions. RESULTS: There were a total of 94 adverse drug reactions in 75 patients. Most reactions were predictable and of moderate severity. The incidence of adverse drug reactions was 16.2%, and the incidence varied, according to the medical specialty; it was higher in Internal Medicine (30%). Antibiotics were the most commonly involved medication. Chronic renal failure, longer hospital stay, greater number of diagnoses and greater number of medications upon admission were risk factors. For each medication introduced during hospitalization, there was a 10% increase in the rate of adverse drug reaction. In the present study, the probability of observing an adverse drug reaction was 1 in 104 patients per day. CONCLUSIONS: Adverse drug reactions are frequent and potentially serious and should be better monitored in patients with chronic renal failure or prolonged hospitalization and especially in those on ‘polypharmacy’ regimens. The rational use of medications plays an important role in preventing adverse drug reactions. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/143350 10.6061/clinics/2018/e185 |
url |
https://www.revistas.usp.br/clinics/article/view/143350 |
identifier_str_mv |
10.6061/clinics/2018/e185 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/143350/138062 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 73 (2018); e185 Clinics; v. 73 (2018); e185 Clinics; Vol. 73 (2018); e185 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222763644878849 |