Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Marisa Rosimeire
Data de Publicação: 2018
Outros Autores: Motta, Antonio Abílio, Marcondes-Fonseca, Luiz Augusto, Kalil-Filho, Jorge, Giavina-Bianchi, Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/143350
Resumo: OBJECTIVE: To assess the risk factors, incidence and severity of adverse drug reactions in in-patients. METHODS: This prospective study evaluated 472 patients treated at a teaching hospital in Brazil between 2010 and 2013 by five medical specialties: Internal Medicine, General Surgery, Geriatrics, Neurology, and Clinical Immunology and Allergy. The following variables were assessed: patient age, gender, comorbidities, family history of hypersensitivity, personal and family history of atopy, number of prescribed drugs before and during hospitalization, hospital diagnoses, days of hospitalization. The patients were visited every other day, and medical records were reviewed by the investigators to detect adverse drug reactions. RESULTS: There were a total of 94 adverse drug reactions in 75 patients. Most reactions were predictable and of moderate severity. The incidence of adverse drug reactions was 16.2%, and the incidence varied, according to the medical specialty; it was higher in Internal Medicine (30%). Antibiotics were the most commonly involved medication. Chronic renal failure, longer hospital stay, greater number of diagnoses and greater number of medications upon admission were risk factors. For each medication introduced during hospitalization, there was a 10% increase in the rate of adverse drug reaction. In the present study, the probability of observing an adverse drug reaction was 1 in 104 patients per day. CONCLUSIONS: Adverse drug reactions are frequent and potentially serious and should be better monitored in patients with chronic renal failure or prolonged hospitalization and especially in those on ‘polypharmacy’ regimens. The rational use of medications plays an important role in preventing adverse drug reactions.
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spelling Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized PatientsAdverse Drug ReactionsHypersensitivity ReactionsIn-patientsIncidenceRisk factorsOBJECTIVE: To assess the risk factors, incidence and severity of adverse drug reactions in in-patients. METHODS: This prospective study evaluated 472 patients treated at a teaching hospital in Brazil between 2010 and 2013 by five medical specialties: Internal Medicine, General Surgery, Geriatrics, Neurology, and Clinical Immunology and Allergy. The following variables were assessed: patient age, gender, comorbidities, family history of hypersensitivity, personal and family history of atopy, number of prescribed drugs before and during hospitalization, hospital diagnoses, days of hospitalization. The patients were visited every other day, and medical records were reviewed by the investigators to detect adverse drug reactions. RESULTS: There were a total of 94 adverse drug reactions in 75 patients. Most reactions were predictable and of moderate severity. The incidence of adverse drug reactions was 16.2%, and the incidence varied, according to the medical specialty; it was higher in Internal Medicine (30%). Antibiotics were the most commonly involved medication. Chronic renal failure, longer hospital stay, greater number of diagnoses and greater number of medications upon admission were risk factors. For each medication introduced during hospitalization, there was a 10% increase in the rate of adverse drug reaction. In the present study, the probability of observing an adverse drug reaction was 1 in 104 patients per day. CONCLUSIONS: Adverse drug reactions are frequent and potentially serious and should be better monitored in patients with chronic renal failure or prolonged hospitalization and especially in those on ‘polypharmacy’ regimens. The rational use of medications plays an important role in preventing adverse drug reactions.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/14335010.6061/clinics/2018/e185Clinics; Vol. 73 (2018); e185Clinics; v. 73 (2018); e185Clinics; Vol. 73 (2018); e1851980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/143350/138062Copyright (c) 2018 Clinicsinfo:eu-repo/semantics/openAccessRibeiro, Marisa RosimeireMotta, Antonio AbílioMarcondes-Fonseca, Luiz AugustoKalil-Filho, JorgeGiavina-Bianchi, Pedro2019-05-14T11:48:50Zoai:revistas.usp.br:article/143350Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-05-14T11:48:50Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients
title Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients
spellingShingle Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients
Ribeiro, Marisa Rosimeire
Adverse Drug Reactions
Hypersensitivity Reactions
In-patients
Incidence
Risk factors
title_short Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients
title_full Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients
title_fullStr Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients
title_full_unstemmed Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients
title_sort Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients
author Ribeiro, Marisa Rosimeire
author_facet Ribeiro, Marisa Rosimeire
Motta, Antonio Abílio
Marcondes-Fonseca, Luiz Augusto
Kalil-Filho, Jorge
Giavina-Bianchi, Pedro
author_role author
author2 Motta, Antonio Abílio
Marcondes-Fonseca, Luiz Augusto
Kalil-Filho, Jorge
Giavina-Bianchi, Pedro
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro, Marisa Rosimeire
Motta, Antonio Abílio
Marcondes-Fonseca, Luiz Augusto
Kalil-Filho, Jorge
Giavina-Bianchi, Pedro
dc.subject.por.fl_str_mv Adverse Drug Reactions
Hypersensitivity Reactions
In-patients
Incidence
Risk factors
topic Adverse Drug Reactions
Hypersensitivity Reactions
In-patients
Incidence
Risk factors
description OBJECTIVE: To assess the risk factors, incidence and severity of adverse drug reactions in in-patients. METHODS: This prospective study evaluated 472 patients treated at a teaching hospital in Brazil between 2010 and 2013 by five medical specialties: Internal Medicine, General Surgery, Geriatrics, Neurology, and Clinical Immunology and Allergy. The following variables were assessed: patient age, gender, comorbidities, family history of hypersensitivity, personal and family history of atopy, number of prescribed drugs before and during hospitalization, hospital diagnoses, days of hospitalization. The patients were visited every other day, and medical records were reviewed by the investigators to detect adverse drug reactions. RESULTS: There were a total of 94 adverse drug reactions in 75 patients. Most reactions were predictable and of moderate severity. The incidence of adverse drug reactions was 16.2%, and the incidence varied, according to the medical specialty; it was higher in Internal Medicine (30%). Antibiotics were the most commonly involved medication. Chronic renal failure, longer hospital stay, greater number of diagnoses and greater number of medications upon admission were risk factors. For each medication introduced during hospitalization, there was a 10% increase in the rate of adverse drug reaction. In the present study, the probability of observing an adverse drug reaction was 1 in 104 patients per day. CONCLUSIONS: Adverse drug reactions are frequent and potentially serious and should be better monitored in patients with chronic renal failure or prolonged hospitalization and especially in those on ‘polypharmacy’ regimens. The rational use of medications plays an important role in preventing adverse drug reactions.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/143350
10.6061/clinics/2018/e185
url https://www.revistas.usp.br/clinics/article/view/143350
identifier_str_mv 10.6061/clinics/2018/e185
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/143350/138062
dc.rights.driver.fl_str_mv Copyright (c) 2018 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 73 (2018); e185
Clinics; v. 73 (2018); e185
Clinics; Vol. 73 (2018); e185
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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