Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/102014 |
Resumo: | OBJECTIVE: Little is known about metabolic factors in cirrhotic patients in China. Therefore, we aimed to quantify the prevalence of both metabolic factors and non-alcoholic steatohepatitis-related liver cirrhosis in China. METHODS: The medical records of 1,582 patients diagnosed with liver cirrhosis from June 2003 to July 2013 at Daping Hospital (Chongqing, China) were retrospectively reviewed through a computer-generated search. RESULTS: Serum hepatitis B virus surface antigen was present in 1,083 (68.5%) patients, and hepatitis B was found to be the only etiological factor in 938 (59.3%) of all patients. Obesity, diabetes mellitus, and arterial hypertension were observed in 229 (14.5%), 159 (10.1%), and 129 (8.2%) patients, respectively. From 2012-2013, the proportion of non-alcoholic steatohepatitis-related liver cirrhosis increased to 3.2%, whereas the average proportion of non-alcoholic steatohepatitis-related liver cirrhosis in the previous ten years was 1.9%. The incidence of hepatocellular carcinoma was much higher in males than in females (6.3% vs. 3.7%, respectively, p=0.036). Obesity and diabetes mellitus did not significantly increase the incidence of hepatocellular carcinoma in the whole cirrhotic group. The presence of hepatitis B virus was the only risk factor for hepatocellular carcinoma in cirrhotic patients (p |
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Clinics |
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Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study OBJECTIVE: Little is known about metabolic factors in cirrhotic patients in China. Therefore, we aimed to quantify the prevalence of both metabolic factors and non-alcoholic steatohepatitis-related liver cirrhosis in China. METHODS: The medical records of 1,582 patients diagnosed with liver cirrhosis from June 2003 to July 2013 at Daping Hospital (Chongqing, China) were retrospectively reviewed through a computer-generated search. RESULTS: Serum hepatitis B virus surface antigen was present in 1,083 (68.5%) patients, and hepatitis B was found to be the only etiological factor in 938 (59.3%) of all patients. Obesity, diabetes mellitus, and arterial hypertension were observed in 229 (14.5%), 159 (10.1%), and 129 (8.2%) patients, respectively. From 2012-2013, the proportion of non-alcoholic steatohepatitis-related liver cirrhosis increased to 3.2%, whereas the average proportion of non-alcoholic steatohepatitis-related liver cirrhosis in the previous ten years was 1.9%. The incidence of hepatocellular carcinoma was much higher in males than in females (6.3% vs. 3.7%, respectively, p=0.036). Obesity and diabetes mellitus did not significantly increase the incidence of hepatocellular carcinoma in the whole cirrhotic group. The presence of hepatitis B virus was the only risk factor for hepatocellular carcinoma in cirrhotic patients (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/10201410.6061/clinics/2015(08)06Clinics; Vol. 70 No. 8 (2015); 563-568Clinics; v. 70 n. 8 (2015); 563-568Clinics; Vol. 70 Núm. 8 (2015); 563-5681980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/102014/100446Copyright (c) 2015 Clinicsinfo:eu-repo/semantics/openAccessXiong, Ji Wang, Jun Huang, Juan Sun, Wenjing Wang, Jun Chen, Dongfeng 2015-08-07T12:48:44Zoai:revistas.usp.br:article/102014Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2015-08-07T12:48:44Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study |
title |
Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study |
spellingShingle |
Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study Xiong, Ji |
title_short |
Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study |
title_full |
Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study |
title_fullStr |
Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study |
title_full_unstemmed |
Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study |
title_sort |
Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study |
author |
Xiong, Ji |
author_facet |
Xiong, Ji Wang, Jun Huang, Juan Sun, Wenjing Chen, Dongfeng |
author_role |
author |
author2 |
Wang, Jun Huang, Juan Sun, Wenjing Chen, Dongfeng |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Xiong, Ji Wang, Jun Huang, Juan Sun, Wenjing Wang, Jun Chen, Dongfeng |
description |
OBJECTIVE: Little is known about metabolic factors in cirrhotic patients in China. Therefore, we aimed to quantify the prevalence of both metabolic factors and non-alcoholic steatohepatitis-related liver cirrhosis in China. METHODS: The medical records of 1,582 patients diagnosed with liver cirrhosis from June 2003 to July 2013 at Daping Hospital (Chongqing, China) were retrospectively reviewed through a computer-generated search. RESULTS: Serum hepatitis B virus surface antigen was present in 1,083 (68.5%) patients, and hepatitis B was found to be the only etiological factor in 938 (59.3%) of all patients. Obesity, diabetes mellitus, and arterial hypertension were observed in 229 (14.5%), 159 (10.1%), and 129 (8.2%) patients, respectively. From 2012-2013, the proportion of non-alcoholic steatohepatitis-related liver cirrhosis increased to 3.2%, whereas the average proportion of non-alcoholic steatohepatitis-related liver cirrhosis in the previous ten years was 1.9%. The incidence of hepatocellular carcinoma was much higher in males than in females (6.3% vs. 3.7%, respectively, p=0.036). Obesity and diabetes mellitus did not significantly increase the incidence of hepatocellular carcinoma in the whole cirrhotic group. The presence of hepatitis B virus was the only risk factor for hepatocellular carcinoma in cirrhotic patients (p |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/102014 10.6061/clinics/2015(08)06 |
url |
https://www.revistas.usp.br/clinics/article/view/102014 |
identifier_str_mv |
10.6061/clinics/2015(08)06 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/102014/100446 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2015 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2015 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 70 No. 8 (2015); 563-568 Clinics; v. 70 n. 8 (2015); 563-568 Clinics; Vol. 70 Núm. 8 (2015); 563-568 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222762195746816 |