Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels

Detalhes bibliográficos
Autor(a) principal: Hoe, See-Ziau
Data de Publicação: 2011
Outros Autores: Lee, Chen-Neng, Mok, Shiueh-Lian, Kamaruddin, Mohd Yusoff, Lam, Sau-Kuen
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/19467
Resumo: INTRODUCTION: Gynura procumbens has been shown to decrease blood pressure via inhibition of the angiotensinconverting enzyme. However, other mechanisms that may contribute to the hypotensive effect have not been studied. OBJECTIVES: To investigate the cardiovascular effects of a butanolic fraction of Gynura procumbens in rats. METHODS: Anaesthetized rats were given intravenous bolus injections of butanolic fraction at doses of 2.5-20 mg/kg in vivo. The effect of butanolic fraction on vascular reactivity was recorded in isolated rat aortic rings in vitro. RESULTS: Intravenous administrations of butanolic fraction elicited significant (p
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spelling Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels Gynura procumbensHypotensionVasodilatationCalcium channelsButanolic fraction INTRODUCTION: Gynura procumbens has been shown to decrease blood pressure via inhibition of the angiotensinconverting enzyme. However, other mechanisms that may contribute to the hypotensive effect have not been studied. OBJECTIVES: To investigate the cardiovascular effects of a butanolic fraction of Gynura procumbens in rats. METHODS: Anaesthetized rats were given intravenous bolus injections of butanolic fraction at doses of 2.5-20 mg/kg in vivo. The effect of butanolic fraction on vascular reactivity was recorded in isolated rat aortic rings in vitro. RESULTS: Intravenous administrations of butanolic fraction elicited significant (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1946710.1590/S1807-59322011000100025Clinics; Vol. 66 No. 1 (2011); 143-150 Clinics; v. 66 n. 1 (2011); 143-150 Clinics; Vol. 66 Núm. 1 (2011); 143-150 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19467/21530Hoe, See-ZiauLee, Chen-NengMok, Shiueh-LianKamaruddin, Mohd YusoffLam, Sau-Kueninfo:eu-repo/semantics/openAccess2012-05-23T16:42:28Zoai:revistas.usp.br:article/19467Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:42:28Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels
title Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels
spellingShingle Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels
Hoe, See-Ziau
Gynura procumbens
Hypotension
Vasodilatation
Calcium channels
Butanolic fraction
title_short Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels
title_full Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels
title_fullStr Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels
title_full_unstemmed Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels
title_sort Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels
author Hoe, See-Ziau
author_facet Hoe, See-Ziau
Lee, Chen-Neng
Mok, Shiueh-Lian
Kamaruddin, Mohd Yusoff
Lam, Sau-Kuen
author_role author
author2 Lee, Chen-Neng
Mok, Shiueh-Lian
Kamaruddin, Mohd Yusoff
Lam, Sau-Kuen
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Hoe, See-Ziau
Lee, Chen-Neng
Mok, Shiueh-Lian
Kamaruddin, Mohd Yusoff
Lam, Sau-Kuen
dc.subject.por.fl_str_mv Gynura procumbens
Hypotension
Vasodilatation
Calcium channels
Butanolic fraction
topic Gynura procumbens
Hypotension
Vasodilatation
Calcium channels
Butanolic fraction
description INTRODUCTION: Gynura procumbens has been shown to decrease blood pressure via inhibition of the angiotensinconverting enzyme. However, other mechanisms that may contribute to the hypotensive effect have not been studied. OBJECTIVES: To investigate the cardiovascular effects of a butanolic fraction of Gynura procumbens in rats. METHODS: Anaesthetized rats were given intravenous bolus injections of butanolic fraction at doses of 2.5-20 mg/kg in vivo. The effect of butanolic fraction on vascular reactivity was recorded in isolated rat aortic rings in vitro. RESULTS: Intravenous administrations of butanolic fraction elicited significant (p
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19467
10.1590/S1807-59322011000100025
url https://www.revistas.usp.br/clinics/article/view/19467
identifier_str_mv 10.1590/S1807-59322011000100025
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19467/21530
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 66 No. 1 (2011); 143-150
Clinics; v. 66 n. 1 (2011); 143-150
Clinics; Vol. 66 Núm. 1 (2011); 143-150
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
_version_ 1800222757315674112

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