Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly

Detalhes bibliográficos
Autor(a) principal: Ladeira, Rodolfo B.
Data de Publicação: 2009
Outros Autores: Diniz, Breno S., Nunes, Paula V., Forlenza, Orestes V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/17922
Resumo: OBJECTIVE: To determine the accuracy of the Mini-Mental State Examination combined with the Verbal Fluency Test and Clock Drawing Test for the identification of patients with mild cognitive impairment and Alzheimer's disease (AD). METHOD: These tests were used to evaluate cognitive function in 247 older adults. Subjects were divided into three groups according to their cognitive state: mild cognitive impairment (n=83), AD (n=81), cognitively unimpaired controls (n=83), based on clinical and neuropsychological data. The diagnostic accuracy of each test for discriminating between these diagnostic groups (mild cognitive impairment or AD vs. controls) was examined with the aid of Receiver Operating Characteristic (ROC) curves. Additionally, we evaluated the benefit of the combination of tests on diagnostic accuracy. RESULTS: Although they were accurate enough for the identification of Alzheimer's disease, neither test alone proved adequate for the correct separation of patients with mild cognitive impairment from healthy subjects. Combining these tests did not improve diagnostic accuracy, as compared to the Mini-Mental State Examination alone, in the identification of patients with mild cognitive impairment or Alzheimer's disease. CONCLUSIONS: The present data do not warrant the combined use of the Mini-Mental State Examination, the Verbal Fluency Test and the Clock Drawing Test as a sufficient diagnostic schedule in screening for mild cognitive impairment. The present data do not support the notion that the combination of test scores is better that the use of Mini-Mental State Examination scores alone in the screening for Alzheimer's disease.
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spelling Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly Alzheimer's diseaseDementiaMild cognitive impairmentDiagnosisNeuropsychology OBJECTIVE: To determine the accuracy of the Mini-Mental State Examination combined with the Verbal Fluency Test and Clock Drawing Test for the identification of patients with mild cognitive impairment and Alzheimer's disease (AD). METHOD: These tests were used to evaluate cognitive function in 247 older adults. Subjects were divided into three groups according to their cognitive state: mild cognitive impairment (n=83), AD (n=81), cognitively unimpaired controls (n=83), based on clinical and neuropsychological data. The diagnostic accuracy of each test for discriminating between these diagnostic groups (mild cognitive impairment or AD vs. controls) was examined with the aid of Receiver Operating Characteristic (ROC) curves. Additionally, we evaluated the benefit of the combination of tests on diagnostic accuracy. RESULTS: Although they were accurate enough for the identification of Alzheimer's disease, neither test alone proved adequate for the correct separation of patients with mild cognitive impairment from healthy subjects. Combining these tests did not improve diagnostic accuracy, as compared to the Mini-Mental State Examination alone, in the identification of patients with mild cognitive impairment or Alzheimer's disease. CONCLUSIONS: The present data do not warrant the combined use of the Mini-Mental State Examination, the Verbal Fluency Test and the Clock Drawing Test as a sufficient diagnostic schedule in screening for mild cognitive impairment. The present data do not support the notion that the combination of test scores is better that the use of Mini-Mental State Examination scores alone in the screening for Alzheimer's disease. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1792210.1590/S1807-59322009001000006Clinics; Vol. 64 No. 10 (2009); 967-973 Clinics; v. 64 n. 10 (2009); 967-973 Clinics; Vol. 64 Núm. 10 (2009); 967-973 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17922/19987Ladeira, Rodolfo B.Diniz, Breno S.Nunes, Paula V.Forlenza, Orestes V.info:eu-repo/semantics/openAccess2012-05-22T18:44:25Zoai:revistas.usp.br:article/17922Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:44:25Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly
title Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly
spellingShingle Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly
Ladeira, Rodolfo B.
Alzheimer's disease
Dementia
Mild cognitive impairment
Diagnosis
Neuropsychology
title_short Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly
title_full Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly
title_fullStr Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly
title_full_unstemmed Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly
title_sort Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly
author Ladeira, Rodolfo B.
author_facet Ladeira, Rodolfo B.
Diniz, Breno S.
Nunes, Paula V.
Forlenza, Orestes V.
author_role author
author2 Diniz, Breno S.
Nunes, Paula V.
Forlenza, Orestes V.
author2_role author
author
author
dc.contributor.author.fl_str_mv Ladeira, Rodolfo B.
Diniz, Breno S.
Nunes, Paula V.
Forlenza, Orestes V.
dc.subject.por.fl_str_mv Alzheimer's disease
Dementia
Mild cognitive impairment
Diagnosis
Neuropsychology
topic Alzheimer's disease
Dementia
Mild cognitive impairment
Diagnosis
Neuropsychology
description OBJECTIVE: To determine the accuracy of the Mini-Mental State Examination combined with the Verbal Fluency Test and Clock Drawing Test for the identification of patients with mild cognitive impairment and Alzheimer's disease (AD). METHOD: These tests were used to evaluate cognitive function in 247 older adults. Subjects were divided into three groups according to their cognitive state: mild cognitive impairment (n=83), AD (n=81), cognitively unimpaired controls (n=83), based on clinical and neuropsychological data. The diagnostic accuracy of each test for discriminating between these diagnostic groups (mild cognitive impairment or AD vs. controls) was examined with the aid of Receiver Operating Characteristic (ROC) curves. Additionally, we evaluated the benefit of the combination of tests on diagnostic accuracy. RESULTS: Although they were accurate enough for the identification of Alzheimer's disease, neither test alone proved adequate for the correct separation of patients with mild cognitive impairment from healthy subjects. Combining these tests did not improve diagnostic accuracy, as compared to the Mini-Mental State Examination alone, in the identification of patients with mild cognitive impairment or Alzheimer's disease. CONCLUSIONS: The present data do not warrant the combined use of the Mini-Mental State Examination, the Verbal Fluency Test and the Clock Drawing Test as a sufficient diagnostic schedule in screening for mild cognitive impairment. The present data do not support the notion that the combination of test scores is better that the use of Mini-Mental State Examination scores alone in the screening for Alzheimer's disease.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17922
10.1590/S1807-59322009001000006
url https://www.revistas.usp.br/clinics/article/view/17922
identifier_str_mv 10.1590/S1807-59322009001000006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17922/19987
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 64 No. 10 (2009); 967-973
Clinics; v. 64 n. 10 (2009); 967-973
Clinics; Vol. 64 Núm. 10 (2009); 967-973
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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