Dysarthria in hereditary spastic paraplegia type 4
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/213653 |
Resumo: | Objective: To describe the speech pattern of patients with hereditary Spastic Paraplegia type 4 (SPG4) and correlated it with their clinical data. Methods: Cross-sectional study was carried out in two university hospitals in Brazil. Two groups participated in the study: the case group (n = 28) with a confirmed genetic diagnosis for SPG4 and a control group (n = 17) matched for sex and age. The speech assessment of both groups included: speech task recording, acoustic analysis, and auditory-perceptual analysis. In addition, disease severity was assessed with the Spastic Paraplegia Rating Scale (SPRS). Results: In the auditory-perceptual analysis, 53.5% (n = 15) of individuals with SPG4 were dysarthric, with mild to moderate changes in the subsystems of phonation and articulation. On acoustic analysis, SPG4 subjects’ performances were worse in measurements related to breathing (maximum phonation time) and articulation (speech rate, articulation rate). The articulation variables (speech rate, articulation rate) are related to the age of onset of the first motor symptom. Conclusion: Dysarthria in SPG4 is frequent and mild, and it did not evolve in conjunction with more advanced motor diseases. This data suggest that diagnosed patients should be screened and referred for speech therapy evaluation and those pathophysiological mechanisms of speech involvement may differ from the length-dependent degeneration of the corticospinal tract. |
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Clinics |
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Dysarthria in hereditary spastic paraplegia type 4Spastic ParaplegiaHereditarySpeechDysarthriaSpeech DisordersObjective: To describe the speech pattern of patients with hereditary Spastic Paraplegia type 4 (SPG4) and correlated it with their clinical data. Methods: Cross-sectional study was carried out in two university hospitals in Brazil. Two groups participated in the study: the case group (n = 28) with a confirmed genetic diagnosis for SPG4 and a control group (n = 17) matched for sex and age. The speech assessment of both groups included: speech task recording, acoustic analysis, and auditory-perceptual analysis. In addition, disease severity was assessed with the Spastic Paraplegia Rating Scale (SPRS). Results: In the auditory-perceptual analysis, 53.5% (n = 15) of individuals with SPG4 were dysarthric, with mild to moderate changes in the subsystems of phonation and articulation. On acoustic analysis, SPG4 subjects’ performances were worse in measurements related to breathing (maximum phonation time) and articulation (speech rate, articulation rate). The articulation variables (speech rate, articulation rate) are related to the age of onset of the first motor symptom. Conclusion: Dysarthria in SPG4 is frequent and mild, and it did not evolve in conjunction with more advanced motor diseases. This data suggest that diagnosed patients should be screened and referred for speech therapy evaluation and those pathophysiological mechanisms of speech involvement may differ from the length-dependent degeneration of the corticospinal tract.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2022-12-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21365310.1016/j.clinsp.2022.100128Clinics; Vol. 78 (2023); 100128Clinics; v. 78 (2023); 100128Clinics; Vol. 78 (2023); 1001281980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/213653/195748Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessJacinto-Scudeiro, Lais AlvesRothe-Neves, RuiSantos, Vanessa Brzoskowski dosMachado, Gustavo DarivaBurguêz, DanielaPadovani, Marina Martins PereiraAyres, AnneliseRech, Rafaela SoaresGonzález-Salazar, CarelisFrança Junior, Marcondes CavalcanteSaute, Jonas Alex MoralesOlchik, Maira Rozenfeld2023-07-06T13:05:37Zoai:revistas.usp.br:article/213653Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:05:37Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Dysarthria in hereditary spastic paraplegia type 4 |
title |
Dysarthria in hereditary spastic paraplegia type 4 |
spellingShingle |
Dysarthria in hereditary spastic paraplegia type 4 Jacinto-Scudeiro, Lais Alves Spastic Paraplegia Hereditary Speech Dysarthria Speech Disorders |
title_short |
Dysarthria in hereditary spastic paraplegia type 4 |
title_full |
Dysarthria in hereditary spastic paraplegia type 4 |
title_fullStr |
Dysarthria in hereditary spastic paraplegia type 4 |
title_full_unstemmed |
Dysarthria in hereditary spastic paraplegia type 4 |
title_sort |
Dysarthria in hereditary spastic paraplegia type 4 |
author |
Jacinto-Scudeiro, Lais Alves |
author_facet |
Jacinto-Scudeiro, Lais Alves Rothe-Neves, Rui Santos, Vanessa Brzoskowski dos Machado, Gustavo Dariva Burguêz, Daniela Padovani, Marina Martins Pereira Ayres, Annelise Rech, Rafaela Soares González-Salazar, Carelis França Junior, Marcondes Cavalcante Saute, Jonas Alex Morales Olchik, Maira Rozenfeld |
author_role |
author |
author2 |
Rothe-Neves, Rui Santos, Vanessa Brzoskowski dos Machado, Gustavo Dariva Burguêz, Daniela Padovani, Marina Martins Pereira Ayres, Annelise Rech, Rafaela Soares González-Salazar, Carelis França Junior, Marcondes Cavalcante Saute, Jonas Alex Morales Olchik, Maira Rozenfeld |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Jacinto-Scudeiro, Lais Alves Rothe-Neves, Rui Santos, Vanessa Brzoskowski dos Machado, Gustavo Dariva Burguêz, Daniela Padovani, Marina Martins Pereira Ayres, Annelise Rech, Rafaela Soares González-Salazar, Carelis França Junior, Marcondes Cavalcante Saute, Jonas Alex Morales Olchik, Maira Rozenfeld |
dc.subject.por.fl_str_mv |
Spastic Paraplegia Hereditary Speech Dysarthria Speech Disorders |
topic |
Spastic Paraplegia Hereditary Speech Dysarthria Speech Disorders |
description |
Objective: To describe the speech pattern of patients with hereditary Spastic Paraplegia type 4 (SPG4) and correlated it with their clinical data. Methods: Cross-sectional study was carried out in two university hospitals in Brazil. Two groups participated in the study: the case group (n = 28) with a confirmed genetic diagnosis for SPG4 and a control group (n = 17) matched for sex and age. The speech assessment of both groups included: speech task recording, acoustic analysis, and auditory-perceptual analysis. In addition, disease severity was assessed with the Spastic Paraplegia Rating Scale (SPRS). Results: In the auditory-perceptual analysis, 53.5% (n = 15) of individuals with SPG4 were dysarthric, with mild to moderate changes in the subsystems of phonation and articulation. On acoustic analysis, SPG4 subjects’ performances were worse in measurements related to breathing (maximum phonation time) and articulation (speech rate, articulation rate). The articulation variables (speech rate, articulation rate) are related to the age of onset of the first motor symptom. Conclusion: Dysarthria in SPG4 is frequent and mild, and it did not evolve in conjunction with more advanced motor diseases. This data suggest that diagnosed patients should be screened and referred for speech therapy evaluation and those pathophysiological mechanisms of speech involvement may differ from the length-dependent degeneration of the corticospinal tract. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-05 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/213653 10.1016/j.clinsp.2022.100128 |
url |
https://www.revistas.usp.br/clinics/article/view/213653 |
identifier_str_mv |
10.1016/j.clinsp.2022.100128 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/213653/195748 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 78 (2023); 100128 Clinics; v. 78 (2023); 100128 Clinics; Vol. 78 (2023); 100128 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222767087353856 |