Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/19641 |
Resumo: | OBJECTIVE: To describe the chest computed tomography findings for severe influenza H1N1 infection in a series of hospitalized neutropenic cancer patients. METHODS: We performed a retrospective systematic analysis of chest computed tomography scans for eight hospitalized patients with fever, neutropenia, and confirmed diagnoses of influenza H1N1. The clinical data had been prospectively collected. RESULTS: Six of eight patients (75%) developed respiratory failure and required intensive care. Prolonged H1N1 shedding was observed in the three mechanically ventilated patients, and overall hospital mortality in our series was 25%. The most frequent computed tomography findings were ground-glass opacity (all patients), consolidation (7/8 cases), and airspace nodules (6/8 cases) that were frequently moderate or severe. Other parenchymal findings were not common. Five patients had features of pneumonia, two had computed tomography findings compatible with bronchitis and/or bronchiolitis, and one had tomographic signs of chronicity. CONCLUSION: In this series of neutropenic patients with severe influenza H1N1 infection, chest computed tomography demonstrated mainly moderate or severe parenchymatous disease, but bronchiolitis was not a common feature. These findings associated with febrile neutropenia should elicit a diagnosis of severe viral infection. |
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Clinics |
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Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patientsH1N1Viral pneumoniaNeutropeniaCancerComputed tomographyOBJECTIVE: To describe the chest computed tomography findings for severe influenza H1N1 infection in a series of hospitalized neutropenic cancer patients. METHODS: We performed a retrospective systematic analysis of chest computed tomography scans for eight hospitalized patients with fever, neutropenia, and confirmed diagnoses of influenza H1N1. The clinical data had been prospectively collected. RESULTS: Six of eight patients (75%) developed respiratory failure and required intensive care. Prolonged H1N1 shedding was observed in the three mechanically ventilated patients, and overall hospital mortality in our series was 25%. The most frequent computed tomography findings were ground-glass opacity (all patients), consolidation (7/8 cases), and airspace nodules (6/8 cases) that were frequently moderate or severe. Other parenchymal findings were not common. Five patients had features of pneumonia, two had computed tomography findings compatible with bronchitis and/or bronchiolitis, and one had tomographic signs of chronicity. CONCLUSION: In this series of neutropenic patients with severe influenza H1N1 infection, chest computed tomography demonstrated mainly moderate or severe parenchymatous disease, but bronchiolitis was not a common feature. These findings associated with febrile neutropenia should elicit a diagnosis of severe viral infection.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1964110.6061/clinics/2012(04)03Clinics; Vol. 67 No. 4 (2012); 313-318Clinics; v. 67 n. 4 (2012); 313-318Clinics; Vol. 67 Núm. 4 (2012); 313-3181980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19641/21705Rodrigues, Rosana SouzaMarchiori, EdsonBozza, Fernando A.Pitrowsky, Melissa TassanoVelasco, EduardoSoares, MárcioSalluh, Jorge I. F.info:eu-repo/semantics/openAccess2012-05-24T18:45:55Zoai:revistas.usp.br:article/19641Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-24T18:45:55Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients |
title |
Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients |
spellingShingle |
Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients Rodrigues, Rosana Souza H1N1 Viral pneumonia Neutropenia Cancer Computed tomography |
title_short |
Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients |
title_full |
Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients |
title_fullStr |
Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients |
title_full_unstemmed |
Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients |
title_sort |
Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients |
author |
Rodrigues, Rosana Souza |
author_facet |
Rodrigues, Rosana Souza Marchiori, Edson Bozza, Fernando A. Pitrowsky, Melissa Tassano Velasco, Eduardo Soares, Márcio Salluh, Jorge I. F. |
author_role |
author |
author2 |
Marchiori, Edson Bozza, Fernando A. Pitrowsky, Melissa Tassano Velasco, Eduardo Soares, Márcio Salluh, Jorge I. F. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, Rosana Souza Marchiori, Edson Bozza, Fernando A. Pitrowsky, Melissa Tassano Velasco, Eduardo Soares, Márcio Salluh, Jorge I. F. |
dc.subject.por.fl_str_mv |
H1N1 Viral pneumonia Neutropenia Cancer Computed tomography |
topic |
H1N1 Viral pneumonia Neutropenia Cancer Computed tomography |
description |
OBJECTIVE: To describe the chest computed tomography findings for severe influenza H1N1 infection in a series of hospitalized neutropenic cancer patients. METHODS: We performed a retrospective systematic analysis of chest computed tomography scans for eight hospitalized patients with fever, neutropenia, and confirmed diagnoses of influenza H1N1. The clinical data had been prospectively collected. RESULTS: Six of eight patients (75%) developed respiratory failure and required intensive care. Prolonged H1N1 shedding was observed in the three mechanically ventilated patients, and overall hospital mortality in our series was 25%. The most frequent computed tomography findings were ground-glass opacity (all patients), consolidation (7/8 cases), and airspace nodules (6/8 cases) that were frequently moderate or severe. Other parenchymal findings were not common. Five patients had features of pneumonia, two had computed tomography findings compatible with bronchitis and/or bronchiolitis, and one had tomographic signs of chronicity. CONCLUSION: In this series of neutropenic patients with severe influenza H1N1 infection, chest computed tomography demonstrated mainly moderate or severe parenchymatous disease, but bronchiolitis was not a common feature. These findings associated with febrile neutropenia should elicit a diagnosis of severe viral infection. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19641 10.6061/clinics/2012(04)03 |
url |
https://www.revistas.usp.br/clinics/article/view/19641 |
identifier_str_mv |
10.6061/clinics/2012(04)03 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19641/21705 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 67 No. 4 (2012); 313-318 Clinics; v. 67 n. 4 (2012); 313-318 Clinics; Vol. 67 Núm. 4 (2012); 313-318 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222758179700736 |