Oxidative stress: therapeutic approaches for cervical cancer treatment

• Autor(a) principal: Silva, Gabriela Ávila Fernandes
• Data de Publicação: 2019
• Outros Autores: Nunes, Rafaella Almeida Lima, Morale, Mirian Galliote, Boccardo, Enrique, Aguayo, Francisco, Termini, Lara
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Clinics
• DOI: 10.6061/clinics/2018/e548s
• Texto Completo: https://www.revistas.usp.br/clinics/article/view/154895
• topic: Tumor Markers; Human Papillomavirus; Redox System; Cervical Cancer

OBJECTIVES: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory responses and reactive oxygen species production. In this context, oxidative stress, chronic inflammation and high-risk human papillomavirus can act in a synergistic manner. To counteract the harmful effects of oxidant species, protective molecules, known as antioxidant defenses, are produced by cells to maintain redox homeostasis. In recent years, the use of natural antioxidants as therapeutic strategies for cancer treatment has attracted the attention of the scientific community. This review discusses specific molecules and mechanisms that can act against or together with oxidative stress, presenting alternatives for cervical cancer prevention and treatment.