Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease

Detalhes bibliográficos
Autor(a) principal: Vilela, Eduardo Machado
Data de Publicação: 2011
Outros Autores: Bastos, Jessica Amaral, Fernandes, Natalia, Ferreira, Ana Paula, Chaoubah, Alfredo, Bastos, Marcus Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/19600
Resumo: OBJECTIVE: To determine the impact of periodontal treatment on serum levels of prohepcidin (the prohormone of hepcidin) and systemic inflammation markers, as well as correlations among these markers, in patients with chronic periodontitis and chronic kidney disease who were not undergoing dialysis. METHODS: We included 56 chronic periodontitis patients, 36 with chronic kidney disease and 20 without systemic diseases and with normal renal function (control group). Chronic kidney disease was defined as suggested by the clinical practice guidelines in the National Kidney Foundation. Chronic periodontitis was defined through clinical attachment level and by probing pocket depth, according to the American Association of Periodontology. The inflammatory markers ultrasensitive C-reactive protein, interleukin-6, and prohepcidin were evaluated before and 3 months after periodontal treatment. RESULTS: The efficacy of periodontal treatment was confirmed by the improvement in clinical parameters of chronic periodontitis in the control and chronic kidney disease groups. Periodontal treatment resulted in significant reductions in ultrasensitive C-reactive protein, interleukin-6 and serum prohepcidin levels in both groups. Moreover, in multivariate linear regression, the reduction in prohepcidin after periodontal treatment was significantly and independently associated with interleukin-6 levels in the control group. CONCLUSIONS: By inducing a decline in the systemic inflammatory response and a decrease in serum prohepcidin, successful periodontal treatment may represent an important means of ameliorating the inflammatory burden seen in patients with chronic kidney disease.
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spelling Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease Prohepcidinhronic periodontitishronic kidney diseaseinflammatory markersperiodontal treatment OBJECTIVE: To determine the impact of periodontal treatment on serum levels of prohepcidin (the prohormone of hepcidin) and systemic inflammation markers, as well as correlations among these markers, in patients with chronic periodontitis and chronic kidney disease who were not undergoing dialysis. METHODS: We included 56 chronic periodontitis patients, 36 with chronic kidney disease and 20 without systemic diseases and with normal renal function (control group). Chronic kidney disease was defined as suggested by the clinical practice guidelines in the National Kidney Foundation. Chronic periodontitis was defined through clinical attachment level and by probing pocket depth, according to the American Association of Periodontology. The inflammatory markers ultrasensitive C-reactive protein, interleukin-6, and prohepcidin were evaluated before and 3 months after periodontal treatment. RESULTS: The efficacy of periodontal treatment was confirmed by the improvement in clinical parameters of chronic periodontitis in the control and chronic kidney disease groups. Periodontal treatment resulted in significant reductions in ultrasensitive C-reactive protein, interleukin-6 and serum prohepcidin levels in both groups. Moreover, in multivariate linear regression, the reduction in prohepcidin after periodontal treatment was significantly and independently associated with interleukin-6 levels in the control group. CONCLUSIONS: By inducing a decline in the systemic inflammatory response and a decrease in serum prohepcidin, successful periodontal treatment may represent an important means of ameliorating the inflammatory burden seen in patients with chronic kidney disease. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1960010.1590/S1807-59322011000400022Clinics; Vol. 66 No. 4 (2011); 657-662 Clinics; v. 66 n. 4 (2011); 657-662 Clinics; Vol. 66 Núm. 4 (2011); 657-662 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19600/21663Vilela, Eduardo MachadoBastos, Jessica AmaralFernandes, NataliaFerreira, Ana PaulaChaoubah, AlfredoBastos, Marcus Gomesinfo:eu-repo/semantics/openAccess2012-05-23T16:50:55Zoai:revistas.usp.br:article/19600Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:50:55Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease
title Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease
spellingShingle Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease
Vilela, Eduardo Machado
Prohepcidin
hronic periodontitis
hronic kidney disease
inflammatory markers
periodontal treatment
title_short Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease
title_full Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease
title_fullStr Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease
title_full_unstemmed Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease
title_sort Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease
author Vilela, Eduardo Machado
author_facet Vilela, Eduardo Machado
Bastos, Jessica Amaral
Fernandes, Natalia
Ferreira, Ana Paula
Chaoubah, Alfredo
Bastos, Marcus Gomes
author_role author
author2 Bastos, Jessica Amaral
Fernandes, Natalia
Ferreira, Ana Paula
Chaoubah, Alfredo
Bastos, Marcus Gomes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vilela, Eduardo Machado
Bastos, Jessica Amaral
Fernandes, Natalia
Ferreira, Ana Paula
Chaoubah, Alfredo
Bastos, Marcus Gomes
dc.subject.por.fl_str_mv Prohepcidin
hronic periodontitis
hronic kidney disease
inflammatory markers
periodontal treatment
topic Prohepcidin
hronic periodontitis
hronic kidney disease
inflammatory markers
periodontal treatment
description OBJECTIVE: To determine the impact of periodontal treatment on serum levels of prohepcidin (the prohormone of hepcidin) and systemic inflammation markers, as well as correlations among these markers, in patients with chronic periodontitis and chronic kidney disease who were not undergoing dialysis. METHODS: We included 56 chronic periodontitis patients, 36 with chronic kidney disease and 20 without systemic diseases and with normal renal function (control group). Chronic kidney disease was defined as suggested by the clinical practice guidelines in the National Kidney Foundation. Chronic periodontitis was defined through clinical attachment level and by probing pocket depth, according to the American Association of Periodontology. The inflammatory markers ultrasensitive C-reactive protein, interleukin-6, and prohepcidin were evaluated before and 3 months after periodontal treatment. RESULTS: The efficacy of periodontal treatment was confirmed by the improvement in clinical parameters of chronic periodontitis in the control and chronic kidney disease groups. Periodontal treatment resulted in significant reductions in ultrasensitive C-reactive protein, interleukin-6 and serum prohepcidin levels in both groups. Moreover, in multivariate linear regression, the reduction in prohepcidin after periodontal treatment was significantly and independently associated with interleukin-6 levels in the control group. CONCLUSIONS: By inducing a decline in the systemic inflammatory response and a decrease in serum prohepcidin, successful periodontal treatment may represent an important means of ameliorating the inflammatory burden seen in patients with chronic kidney disease.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19600
10.1590/S1807-59322011000400022
url https://www.revistas.usp.br/clinics/article/view/19600
identifier_str_mv 10.1590/S1807-59322011000400022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19600/21663
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 66 No. 4 (2011); 657-662
Clinics; v. 66 n. 4 (2011); 657-662
Clinics; Vol. 66 Núm. 4 (2011); 657-662
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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