The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy

Detalhes bibliográficos
Autor(a) principal: Pimentel, Walace de Souza
Data de Publicação: 2012
Outros Autores: Ramires, Felix José Alvarez, lanni, Barbara Maria, Salemi, Vera Maria Cury, Bilate, Angelina Morand Bianchi, Cunha-Neto, Edecio, Oliveira, Adriana Morgan de, Fernandes, Fábio, Mady, Charles
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/45873
Resumo: OBJECTIVE: Chagas' disease has spread throughout Latin America because of the high rate of migration among these countries. Approximately 30% of Chagas' patients will develop cardiomyopathy, and 10% of these will develop severe cardiac damage leading to heart failure. Beta-blockade improves symptoms and survival in heart failure patients; however, its efficacy has not been well established in Chagas' disease. We evaluated the role of carvedilol in cardiac remodeling and mortality in a Chagas' cardiomyopathy animal model. METHODS: We studied Trypanosoma cruzi infection in 55 Syrian hamsters that were divided into three groups: control (15), infected (20), and infected + carvedilol (20). Animals underwent echocardiography, electrocardiography, and morphometry for collagen evaluation in ventricles stained with picrosirius red. RESULTS: The left ventricular diastolic diameter did not change between groups, although it was slightly larger in infected groups, as was left ventricular systolic diameter. Fractional shortening also did not change between groups, although it was slightly lower in infected groups. Collagen accumulation in the interstitial myocardial space was significantly higher in infected groups and was not attenuated by carvedilol. The same response was observed in the perivascular space. The survival curve showed significantly better survival in the control group compared with the infected groups; but no benefit of carvedilol was observed during the study. However, in the acute phase (up to 100 days of infection), carvedilol did reduce mortality. CONCLUSION: Carvedilol did not attenuate cardiac remodeling or mortality in this model of Chagas' cardiomyopathy. The treatment did improve survival in the acute phase of the disease.
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spelling The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathyChagas' CardiomyopathyMyocardial FibrosisBeta-BlockerCardiac DysfunctionMyocardial RemodelingOBJECTIVE: Chagas' disease has spread throughout Latin America because of the high rate of migration among these countries. Approximately 30% of Chagas' patients will develop cardiomyopathy, and 10% of these will develop severe cardiac damage leading to heart failure. Beta-blockade improves symptoms and survival in heart failure patients; however, its efficacy has not been well established in Chagas' disease. We evaluated the role of carvedilol in cardiac remodeling and mortality in a Chagas' cardiomyopathy animal model. METHODS: We studied Trypanosoma cruzi infection in 55 Syrian hamsters that were divided into three groups: control (15), infected (20), and infected + carvedilol (20). Animals underwent echocardiography, electrocardiography, and morphometry for collagen evaluation in ventricles stained with picrosirius red. RESULTS: The left ventricular diastolic diameter did not change between groups, although it was slightly larger in infected groups, as was left ventricular systolic diameter. Fractional shortening also did not change between groups, although it was slightly lower in infected groups. Collagen accumulation in the interstitial myocardial space was significantly higher in infected groups and was not attenuated by carvedilol. The same response was observed in the perivascular space. The survival curve showed significantly better survival in the control group compared with the infected groups; but no benefit of carvedilol was observed during the study. However, in the acute phase (up to 100 days of infection), carvedilol did reduce mortality. CONCLUSION: Carvedilol did not attenuate cardiac remodeling or mortality in this model of Chagas' cardiomyopathy. The treatment did improve survival in the acute phase of the disease.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/4587310.6061/clinics/2012(09)14Clinics; Vol. 67 No. 9 (2012); 1063-1069Clinics; v. 67 n. 9 (2012); 1063-1069Clinics; Vol. 67 Núm. 9 (2012); 1063-10691980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/45873/49476Pimentel, Walace de SouzaRamires, Felix José Alvarezlanni, Barbara MariaSalemi, Vera Maria CuryBilate, Angelina Morand BianchiCunha-Neto, EdecioOliveira, Adriana Morgan deFernandes, FábioMady, Charlesinfo:eu-repo/semantics/openAccess2012-10-10T20:42:29Zoai:revistas.usp.br:article/45873Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-10-10T20:42:29Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy
title The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy
spellingShingle The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy
Pimentel, Walace de Souza
Chagas' Cardiomyopathy
Myocardial Fibrosis
Beta-Blocker
Cardiac Dysfunction
Myocardial Remodeling
title_short The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy
title_full The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy
title_fullStr The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy
title_full_unstemmed The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy
title_sort The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy
author Pimentel, Walace de Souza
author_facet Pimentel, Walace de Souza
Ramires, Felix José Alvarez
lanni, Barbara Maria
Salemi, Vera Maria Cury
Bilate, Angelina Morand Bianchi
Cunha-Neto, Edecio
Oliveira, Adriana Morgan de
Fernandes, Fábio
Mady, Charles
author_role author
author2 Ramires, Felix José Alvarez
lanni, Barbara Maria
Salemi, Vera Maria Cury
Bilate, Angelina Morand Bianchi
Cunha-Neto, Edecio
Oliveira, Adriana Morgan de
Fernandes, Fábio
Mady, Charles
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pimentel, Walace de Souza
Ramires, Felix José Alvarez
lanni, Barbara Maria
Salemi, Vera Maria Cury
Bilate, Angelina Morand Bianchi
Cunha-Neto, Edecio
Oliveira, Adriana Morgan de
Fernandes, Fábio
Mady, Charles
dc.subject.por.fl_str_mv Chagas' Cardiomyopathy
Myocardial Fibrosis
Beta-Blocker
Cardiac Dysfunction
Myocardial Remodeling
topic Chagas' Cardiomyopathy
Myocardial Fibrosis
Beta-Blocker
Cardiac Dysfunction
Myocardial Remodeling
description OBJECTIVE: Chagas' disease has spread throughout Latin America because of the high rate of migration among these countries. Approximately 30% of Chagas' patients will develop cardiomyopathy, and 10% of these will develop severe cardiac damage leading to heart failure. Beta-blockade improves symptoms and survival in heart failure patients; however, its efficacy has not been well established in Chagas' disease. We evaluated the role of carvedilol in cardiac remodeling and mortality in a Chagas' cardiomyopathy animal model. METHODS: We studied Trypanosoma cruzi infection in 55 Syrian hamsters that were divided into three groups: control (15), infected (20), and infected + carvedilol (20). Animals underwent echocardiography, electrocardiography, and morphometry for collagen evaluation in ventricles stained with picrosirius red. RESULTS: The left ventricular diastolic diameter did not change between groups, although it was slightly larger in infected groups, as was left ventricular systolic diameter. Fractional shortening also did not change between groups, although it was slightly lower in infected groups. Collagen accumulation in the interstitial myocardial space was significantly higher in infected groups and was not attenuated by carvedilol. The same response was observed in the perivascular space. The survival curve showed significantly better survival in the control group compared with the infected groups; but no benefit of carvedilol was observed during the study. However, in the acute phase (up to 100 days of infection), carvedilol did reduce mortality. CONCLUSION: Carvedilol did not attenuate cardiac remodeling or mortality in this model of Chagas' cardiomyopathy. The treatment did improve survival in the acute phase of the disease.
publishDate 2012
dc.date.none.fl_str_mv 2012-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/45873
10.6061/clinics/2012(09)14
url https://www.revistas.usp.br/clinics/article/view/45873
identifier_str_mv 10.6061/clinics/2012(09)14
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/45873/49476
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 67 No. 9 (2012); 1063-1069
Clinics; v. 67 n. 9 (2012); 1063-1069
Clinics; Vol. 67 Núm. 9 (2012); 1063-1069
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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