Fatal pulmonary embolism in hospitalized patients: a large autopsy-based matched case-control study
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/76846 |
Resumo: | OBJECTIVE: Pulmonary embolism is an underdiagnosed major cause of death for hospitalized patients. The objective of this study was to identify the conditions associated with fatal pulmonary embolism in this population. METHODS: A total of 13,074 autopsy records were evaluated in a case-control study. Patients were matched by age, sex, and year of death, and factors potentially associated with fatal pulmonary embolism were analyzed using univariate and multivariate conditional logistic regression. RESULTS: Pulmonary embolism was considered fatal in 328 (2.5%) patients. In the multivariate analysis, conditions that were more common in patients who died of pulmonary embolism were atherosclerosis, congestive heart failure, and neurological surgery. Some conditions were negatively associated with fatal pulmonary embolism, including hemorrhagic stroke, aortic aneurism, cirrhosis, acquired immune deficiency syndrome, and pneumonia. In the control group, patients with hemorrhagic stroke and aortic aneurism had short hospital stays (8.5 and 8.8 days, respectively), and the hemorrhage itself was the main cause of death in most of them (90.6% and 68.4%, respectively), which may have prevented the development of pulmonary embolism. Cirrhotic patients in the control group also had short hospital stays (7 days), and 50% died from bleeding complications. CONCLUSIONS: In this large autopsy study, atherosclerosis, congestive heart failure, and neurological surgery were diagnoses associated with fatal pulmonary embolism. |
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Clinics |
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Fatal pulmonary embolism in hospitalized patients: a large autopsy-based matched case-control studyOBJECTIVE: Pulmonary embolism is an underdiagnosed major cause of death for hospitalized patients. The objective of this study was to identify the conditions associated with fatal pulmonary embolism in this population. METHODS: A total of 13,074 autopsy records were evaluated in a case-control study. Patients were matched by age, sex, and year of death, and factors potentially associated with fatal pulmonary embolism were analyzed using univariate and multivariate conditional logistic regression. RESULTS: Pulmonary embolism was considered fatal in 328 (2.5%) patients. In the multivariate analysis, conditions that were more common in patients who died of pulmonary embolism were atherosclerosis, congestive heart failure, and neurological surgery. Some conditions were negatively associated with fatal pulmonary embolism, including hemorrhagic stroke, aortic aneurism, cirrhosis, acquired immune deficiency syndrome, and pneumonia. In the control group, patients with hemorrhagic stroke and aortic aneurism had short hospital stays (8.5 and 8.8 days, respectively), and the hemorrhage itself was the main cause of death in most of them (90.6% and 68.4%, respectively), which may have prevented the development of pulmonary embolism. Cirrhotic patients in the control group also had short hospital stays (7 days), and 50% died from bleeding complications. CONCLUSIONS: In this large autopsy study, atherosclerosis, congestive heart failure, and neurological surgery were diagnoses associated with fatal pulmonary embolism.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2013-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/7684610.1590/clin.v68i5.76846Clinics; Vol. 68 No. 5 (2013); 679-685Clinics; v. 68 n. 5 (2013); 679-685Clinics; Vol. 68 Núm. 5 (2013); 679-6851980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/76846/80708Carvalho Bricola, Solange Aparecida PetiloPaiva, Edison FerreiraLichtenstein, ArnaldoGianini, Reinaldo JoséDuarte, Jurandir GodoyShinjo, Samuel KatsuyukiEluf-Neto, JoseArruda Martins, Miltoninfo:eu-repo/semantics/openAccess2014-03-21T19:31:26Zoai:revistas.usp.br:article/76846Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2014-03-21T19:31:26Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Fatal pulmonary embolism in hospitalized patients: a large autopsy-based matched case-control study |
title |
Fatal pulmonary embolism in hospitalized patients: a large autopsy-based matched case-control study |
spellingShingle |
Fatal pulmonary embolism in hospitalized patients: a large autopsy-based matched case-control study Carvalho Bricola, Solange Aparecida Petilo |
title_short |
Fatal pulmonary embolism in hospitalized patients: a large autopsy-based matched case-control study |
title_full |
Fatal pulmonary embolism in hospitalized patients: a large autopsy-based matched case-control study |
title_fullStr |
Fatal pulmonary embolism in hospitalized patients: a large autopsy-based matched case-control study |
title_full_unstemmed |
Fatal pulmonary embolism in hospitalized patients: a large autopsy-based matched case-control study |
title_sort |
Fatal pulmonary embolism in hospitalized patients: a large autopsy-based matched case-control study |
author |
Carvalho Bricola, Solange Aparecida Petilo |
author_facet |
Carvalho Bricola, Solange Aparecida Petilo Paiva, Edison Ferreira Lichtenstein, Arnaldo Gianini, Reinaldo José Duarte, Jurandir Godoy Shinjo, Samuel Katsuyuki Eluf-Neto, Jose Arruda Martins, Milton |
author_role |
author |
author2 |
Paiva, Edison Ferreira Lichtenstein, Arnaldo Gianini, Reinaldo José Duarte, Jurandir Godoy Shinjo, Samuel Katsuyuki Eluf-Neto, Jose Arruda Martins, Milton |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho Bricola, Solange Aparecida Petilo Paiva, Edison Ferreira Lichtenstein, Arnaldo Gianini, Reinaldo José Duarte, Jurandir Godoy Shinjo, Samuel Katsuyuki Eluf-Neto, Jose Arruda Martins, Milton |
description |
OBJECTIVE: Pulmonary embolism is an underdiagnosed major cause of death for hospitalized patients. The objective of this study was to identify the conditions associated with fatal pulmonary embolism in this population. METHODS: A total of 13,074 autopsy records were evaluated in a case-control study. Patients were matched by age, sex, and year of death, and factors potentially associated with fatal pulmonary embolism were analyzed using univariate and multivariate conditional logistic regression. RESULTS: Pulmonary embolism was considered fatal in 328 (2.5%) patients. In the multivariate analysis, conditions that were more common in patients who died of pulmonary embolism were atherosclerosis, congestive heart failure, and neurological surgery. Some conditions were negatively associated with fatal pulmonary embolism, including hemorrhagic stroke, aortic aneurism, cirrhosis, acquired immune deficiency syndrome, and pneumonia. In the control group, patients with hemorrhagic stroke and aortic aneurism had short hospital stays (8.5 and 8.8 days, respectively), and the hemorrhage itself was the main cause of death in most of them (90.6% and 68.4%, respectively), which may have prevented the development of pulmonary embolism. Cirrhotic patients in the control group also had short hospital stays (7 days), and 50% died from bleeding complications. CONCLUSIONS: In this large autopsy study, atherosclerosis, congestive heart failure, and neurological surgery were diagnoses associated with fatal pulmonary embolism. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/76846 10.1590/clin.v68i5.76846 |
url |
https://www.revistas.usp.br/clinics/article/view/76846 |
identifier_str_mv |
10.1590/clin.v68i5.76846 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/76846/80708 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 68 No. 5 (2013); 679-685 Clinics; v. 68 n. 5 (2013); 679-685 Clinics; Vol. 68 Núm. 5 (2013); 679-685 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222760180383744 |