Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19

Detalhes bibliográficos
Autor(a) principal: Theodoro-Filho, Jair
Data de Publicação: 2021
Outros Autores: Monteiro, Renata Aparecida de Almeida, Duarte-Neto, Amaro Nunes, Mauad, Thais, Silva, Luiz Fernando Ferraz da, Saldiva, Paulo Hilário Nascimento, Dolhnikoff, Marisa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/212944
Resumo: OBJECTIVES: Ultrasound-guided minimally invasive autopsies (MIA-US) are an alternative to conventional autopsies and have been used in our institution to investigate the pathophysiology of COVID-19 since the beginning of the pandemic. Owing to the limitations of post-mortem biopsies for evaluating cardiopulmonary events involving large vessels, we continuously improved the technique during this period. Objectives: To demonstrate the usefulness of an extended MIA-US technique (EMIA-US) for the study of thoracic involvement in COVID-19. METHOD: US-guided percutaneous tissue sampling was combined with a small thoracic incision (≤5 cm), allowing for the sampling of larger tissue samples or even the entire organ (lungs and heart). RESULTS: EMIA-US was performed for eight patients who died of COVID-19 in 2021. We demonstrate cardiopulmonary events, mainly thromboembolism and myocardial infarction, that could be evaluated using EMIA-US. CONCLUSIONS: Minimally invasive image-guided post-mortem tissue sampling is a flexible and practical method to conduct post-mortem studies of human diseases, mainly in areas that do not have autopsy facilities or, alternatively, when autopsy is not possible owing to financial constraints, cultural and religious values, or for safety reasons, such as in the case of highly contagious infectious diseases. We present evidence that EMIA-US is feasible and can be used as an alternative to increase the accuracy of MIA-US in detecting cardiopulmonary events involving large vessels, which may not be assessed through post-mortem biopsies.
id USP-19_70ddbabc7b1931fec6e6324a7a52d887
oai_identifier_str oai:revistas.usp.br:article/212944
network_acronym_str USP-19
network_name_str Clinics
repository_id_str
spelling Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19AutopsyMinimally Invasive AutopsyOBJECTIVES: Ultrasound-guided minimally invasive autopsies (MIA-US) are an alternative to conventional autopsies and have been used in our institution to investigate the pathophysiology of COVID-19 since the beginning of the pandemic. Owing to the limitations of post-mortem biopsies for evaluating cardiopulmonary events involving large vessels, we continuously improved the technique during this period. Objectives: To demonstrate the usefulness of an extended MIA-US technique (EMIA-US) for the study of thoracic involvement in COVID-19. METHOD: US-guided percutaneous tissue sampling was combined with a small thoracic incision (≤5 cm), allowing for the sampling of larger tissue samples or even the entire organ (lungs and heart). RESULTS: EMIA-US was performed for eight patients who died of COVID-19 in 2021. We demonstrate cardiopulmonary events, mainly thromboembolism and myocardial infarction, that could be evaluated using EMIA-US. CONCLUSIONS: Minimally invasive image-guided post-mortem tissue sampling is a flexible and practical method to conduct post-mortem studies of human diseases, mainly in areas that do not have autopsy facilities or, alternatively, when autopsy is not possible owing to financial constraints, cultural and religious values, or for safety reasons, such as in the case of highly contagious infectious diseases. We present evidence that EMIA-US is feasible and can be used as an alternative to increase the accuracy of MIA-US in detecting cardiopulmonary events involving large vessels, which may not be assessed through post-mortem biopsies.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2021-11-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21294410.6061/clinics/2021/e3543Clinics; Vol. 76 (2021); e3543Clinics; v. 76 (2021); e3543Clinics; Vol. 76 (2021); e35431980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/212944/194985Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessTheodoro-Filho, JairMonteiro, Renata Aparecida de AlmeidaDuarte-Neto, Amaro NunesMauad, ThaisSilva, Luiz Fernando Ferraz daSaldiva, Paulo Hilário NascimentoDolhnikoff, Marisa2023-07-06T13:04:05Zoai:revistas.usp.br:article/212944Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:04:05Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19
title Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19
spellingShingle Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19
Theodoro-Filho, Jair
Autopsy
Minimally Invasive Autopsy
title_short Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19
title_full Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19
title_fullStr Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19
title_full_unstemmed Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19
title_sort Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19
author Theodoro-Filho, Jair
author_facet Theodoro-Filho, Jair
Monteiro, Renata Aparecida de Almeida
Duarte-Neto, Amaro Nunes
Mauad, Thais
Silva, Luiz Fernando Ferraz da
Saldiva, Paulo Hilário Nascimento
Dolhnikoff, Marisa
author_role author
author2 Monteiro, Renata Aparecida de Almeida
Duarte-Neto, Amaro Nunes
Mauad, Thais
Silva, Luiz Fernando Ferraz da
Saldiva, Paulo Hilário Nascimento
Dolhnikoff, Marisa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Theodoro-Filho, Jair
Monteiro, Renata Aparecida de Almeida
Duarte-Neto, Amaro Nunes
Mauad, Thais
Silva, Luiz Fernando Ferraz da
Saldiva, Paulo Hilário Nascimento
Dolhnikoff, Marisa
dc.subject.por.fl_str_mv Autopsy
Minimally Invasive Autopsy
topic Autopsy
Minimally Invasive Autopsy
description OBJECTIVES: Ultrasound-guided minimally invasive autopsies (MIA-US) are an alternative to conventional autopsies and have been used in our institution to investigate the pathophysiology of COVID-19 since the beginning of the pandemic. Owing to the limitations of post-mortem biopsies for evaluating cardiopulmonary events involving large vessels, we continuously improved the technique during this period. Objectives: To demonstrate the usefulness of an extended MIA-US technique (EMIA-US) for the study of thoracic involvement in COVID-19. METHOD: US-guided percutaneous tissue sampling was combined with a small thoracic incision (≤5 cm), allowing for the sampling of larger tissue samples or even the entire organ (lungs and heart). RESULTS: EMIA-US was performed for eight patients who died of COVID-19 in 2021. We demonstrate cardiopulmonary events, mainly thromboembolism and myocardial infarction, that could be evaluated using EMIA-US. CONCLUSIONS: Minimally invasive image-guided post-mortem tissue sampling is a flexible and practical method to conduct post-mortem studies of human diseases, mainly in areas that do not have autopsy facilities or, alternatively, when autopsy is not possible owing to financial constraints, cultural and religious values, or for safety reasons, such as in the case of highly contagious infectious diseases. We present evidence that EMIA-US is feasible and can be used as an alternative to increase the accuracy of MIA-US in detecting cardiopulmonary events involving large vessels, which may not be assessed through post-mortem biopsies.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-26
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/212944
10.6061/clinics/2021/e3543
url https://www.revistas.usp.br/clinics/article/view/212944
identifier_str_mv 10.6061/clinics/2021/e3543
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/212944/194985
dc.rights.driver.fl_str_mv Copyright (c) 2023 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 76 (2021); e3543
Clinics; v. 76 (2021); e3543
Clinics; Vol. 76 (2021); e3543
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
_version_ 1800222766136295424