Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/212944 |
Resumo: | OBJECTIVES: Ultrasound-guided minimally invasive autopsies (MIA-US) are an alternative to conventional autopsies and have been used in our institution to investigate the pathophysiology of COVID-19 since the beginning of the pandemic. Owing to the limitations of post-mortem biopsies for evaluating cardiopulmonary events involving large vessels, we continuously improved the technique during this period. Objectives: To demonstrate the usefulness of an extended MIA-US technique (EMIA-US) for the study of thoracic involvement in COVID-19. METHOD: US-guided percutaneous tissue sampling was combined with a small thoracic incision (≤5 cm), allowing for the sampling of larger tissue samples or even the entire organ (lungs and heart). RESULTS: EMIA-US was performed for eight patients who died of COVID-19 in 2021. We demonstrate cardiopulmonary events, mainly thromboembolism and myocardial infarction, that could be evaluated using EMIA-US. CONCLUSIONS: Minimally invasive image-guided post-mortem tissue sampling is a flexible and practical method to conduct post-mortem studies of human diseases, mainly in areas that do not have autopsy facilities or, alternatively, when autopsy is not possible owing to financial constraints, cultural and religious values, or for safety reasons, such as in the case of highly contagious infectious diseases. We present evidence that EMIA-US is feasible and can be used as an alternative to increase the accuracy of MIA-US in detecting cardiopulmonary events involving large vessels, which may not be assessed through post-mortem biopsies. |
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oai:revistas.usp.br:article/212944 |
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Clinics |
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Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19AutopsyMinimally Invasive AutopsyOBJECTIVES: Ultrasound-guided minimally invasive autopsies (MIA-US) are an alternative to conventional autopsies and have been used in our institution to investigate the pathophysiology of COVID-19 since the beginning of the pandemic. Owing to the limitations of post-mortem biopsies for evaluating cardiopulmonary events involving large vessels, we continuously improved the technique during this period. Objectives: To demonstrate the usefulness of an extended MIA-US technique (EMIA-US) for the study of thoracic involvement in COVID-19. METHOD: US-guided percutaneous tissue sampling was combined with a small thoracic incision (≤5 cm), allowing for the sampling of larger tissue samples or even the entire organ (lungs and heart). RESULTS: EMIA-US was performed for eight patients who died of COVID-19 in 2021. We demonstrate cardiopulmonary events, mainly thromboembolism and myocardial infarction, that could be evaluated using EMIA-US. CONCLUSIONS: Minimally invasive image-guided post-mortem tissue sampling is a flexible and practical method to conduct post-mortem studies of human diseases, mainly in areas that do not have autopsy facilities or, alternatively, when autopsy is not possible owing to financial constraints, cultural and religious values, or for safety reasons, such as in the case of highly contagious infectious diseases. We present evidence that EMIA-US is feasible and can be used as an alternative to increase the accuracy of MIA-US in detecting cardiopulmonary events involving large vessels, which may not be assessed through post-mortem biopsies.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2021-11-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21294410.6061/clinics/2021/e3543Clinics; Vol. 76 (2021); e3543Clinics; v. 76 (2021); e3543Clinics; Vol. 76 (2021); e35431980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/212944/194985Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessTheodoro-Filho, JairMonteiro, Renata Aparecida de AlmeidaDuarte-Neto, Amaro NunesMauad, ThaisSilva, Luiz Fernando Ferraz daSaldiva, Paulo Hilário NascimentoDolhnikoff, Marisa2023-07-06T13:04:05Zoai:revistas.usp.br:article/212944Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:04:05Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19 |
title |
Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19 |
spellingShingle |
Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19 Theodoro-Filho, Jair Autopsy Minimally Invasive Autopsy |
title_short |
Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19 |
title_full |
Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19 |
title_fullStr |
Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19 |
title_full_unstemmed |
Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19 |
title_sort |
Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19 |
author |
Theodoro-Filho, Jair |
author_facet |
Theodoro-Filho, Jair Monteiro, Renata Aparecida de Almeida Duarte-Neto, Amaro Nunes Mauad, Thais Silva, Luiz Fernando Ferraz da Saldiva, Paulo Hilário Nascimento Dolhnikoff, Marisa |
author_role |
author |
author2 |
Monteiro, Renata Aparecida de Almeida Duarte-Neto, Amaro Nunes Mauad, Thais Silva, Luiz Fernando Ferraz da Saldiva, Paulo Hilário Nascimento Dolhnikoff, Marisa |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Theodoro-Filho, Jair Monteiro, Renata Aparecida de Almeida Duarte-Neto, Amaro Nunes Mauad, Thais Silva, Luiz Fernando Ferraz da Saldiva, Paulo Hilário Nascimento Dolhnikoff, Marisa |
dc.subject.por.fl_str_mv |
Autopsy Minimally Invasive Autopsy |
topic |
Autopsy Minimally Invasive Autopsy |
description |
OBJECTIVES: Ultrasound-guided minimally invasive autopsies (MIA-US) are an alternative to conventional autopsies and have been used in our institution to investigate the pathophysiology of COVID-19 since the beginning of the pandemic. Owing to the limitations of post-mortem biopsies for evaluating cardiopulmonary events involving large vessels, we continuously improved the technique during this period. Objectives: To demonstrate the usefulness of an extended MIA-US technique (EMIA-US) for the study of thoracic involvement in COVID-19. METHOD: US-guided percutaneous tissue sampling was combined with a small thoracic incision (≤5 cm), allowing for the sampling of larger tissue samples or even the entire organ (lungs and heart). RESULTS: EMIA-US was performed for eight patients who died of COVID-19 in 2021. We demonstrate cardiopulmonary events, mainly thromboembolism and myocardial infarction, that could be evaluated using EMIA-US. CONCLUSIONS: Minimally invasive image-guided post-mortem tissue sampling is a flexible and practical method to conduct post-mortem studies of human diseases, mainly in areas that do not have autopsy facilities or, alternatively, when autopsy is not possible owing to financial constraints, cultural and religious values, or for safety reasons, such as in the case of highly contagious infectious diseases. We present evidence that EMIA-US is feasible and can be used as an alternative to increase the accuracy of MIA-US in detecting cardiopulmonary events involving large vessels, which may not be assessed through post-mortem biopsies. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/212944 10.6061/clinics/2021/e3543 |
url |
https://www.revistas.usp.br/clinics/article/view/212944 |
identifier_str_mv |
10.6061/clinics/2021/e3543 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/212944/194985 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 76 (2021); e3543 Clinics; v. 76 (2021); e3543 Clinics; Vol. 76 (2021); e3543 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222766136295424 |