The effect of acute magnesium loading on the maximal exercise performance of stable chronic obstructive pulmonary disease patients
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/40016 |
Resumo: | OBJECTIVE: The potential influence of magnesium on exercise performance is a subject of increasing interest. Magnesium has been shown to have bronchodilatatory properties in asthma and chronic obstructive pulmonary disease patients. The aim of this study was to investigate the effects of acute magnesium IV loading on the aerobic exercise performance of stable chronic obstructive pulmonary disease patients. METHODS: Twenty male chronic obstructive pulmonary disease patients (66.2 + 8.3 years old, FEV1: 49.3+19.8%) received an IV infusion of 2 g of either magnesium sulfate or saline on two randomly assigned occasions approximately two days apart. Spirometry was performed both before and 45 minutes after the infusions. A symptom-limited incremental maximal cardiopulmonary test was performed on a cycle ergometer at approximately 100 minutes after the end of the infusion. ClinicalTrials.gov: NCT00500864 RESULTS: Magnesium infusion was associated with significant reductions in the functional residual capacity (-0.41 l) and residual volume (-0.47 l), the mean arterial blood pressure (-5.6 mmHg) and the cardiac double product (734.8 mmHg.bpm) at rest. Magnesium treatment led to significant increases in the maximal load reached (+8 w) and the respiratory exchange ratio (0.06) at peak exercise. The subgroup of patients who showed increases in the work load equal to or greater than 5 w also exhibited significantly greater improvements in inspiratory capacity (0.29 l). CONCLUSIONS: The acute IV loading of magnesium promotes a reduction in static lung hyperinflation and improves the exercise performance in stable chronic obstructive pulmonary disease patients. Improvements in respiratory mechanics appear to be responsible for the latter finding. |
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Clinics |
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The effect of acute magnesium loading on the maximal exercise performance of stable chronic obstructive pulmonary disease patientsPulmonary DiseaseChronic ObstructiveMagnesiumCardiopulmonary Exercise TestSpirometryBlood PressureCirculatory and Respiratory PhysiologyOBJECTIVE: The potential influence of magnesium on exercise performance is a subject of increasing interest. Magnesium has been shown to have bronchodilatatory properties in asthma and chronic obstructive pulmonary disease patients. The aim of this study was to investigate the effects of acute magnesium IV loading on the aerobic exercise performance of stable chronic obstructive pulmonary disease patients. METHODS: Twenty male chronic obstructive pulmonary disease patients (66.2 + 8.3 years old, FEV1: 49.3+19.8%) received an IV infusion of 2 g of either magnesium sulfate or saline on two randomly assigned occasions approximately two days apart. Spirometry was performed both before and 45 minutes after the infusions. A symptom-limited incremental maximal cardiopulmonary test was performed on a cycle ergometer at approximately 100 minutes after the end of the infusion. ClinicalTrials.gov: NCT00500864 RESULTS: Magnesium infusion was associated with significant reductions in the functional residual capacity (-0.41 l) and residual volume (-0.47 l), the mean arterial blood pressure (-5.6 mmHg) and the cardiac double product (734.8 mmHg.bpm) at rest. Magnesium treatment led to significant increases in the maximal load reached (+8 w) and the respiratory exchange ratio (0.06) at peak exercise. The subgroup of patients who showed increases in the work load equal to or greater than 5 w also exhibited significantly greater improvements in inspiratory capacity (0.29 l). CONCLUSIONS: The acute IV loading of magnesium promotes a reduction in static lung hyperinflation and improves the exercise performance in stable chronic obstructive pulmonary disease patients. Improvements in respiratory mechanics appear to be responsible for the latter finding.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/4001610.6061/clinics/2012(06)12Clinics; Vol. 67 No. 6 (2012); 615-622Clinics; v. 67 n. 6 (2012); 615-622Clinics; Vol. 67 Núm. 6 (2012); 615-6221980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/40016/42882Amaral, Angélica Florípedes doGallo Jr., LourencoVannucchi, HélioCrescêncio, Júlio CésarVianna, Elcio OliveiraMartinez, José Antônio Baddiniinfo:eu-repo/semantics/openAccess2012-08-23T18:00:38Zoai:revistas.usp.br:article/40016Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-08-23T18:00:38Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
The effect of acute magnesium loading on the maximal exercise performance of stable chronic obstructive pulmonary disease patients |
title |
The effect of acute magnesium loading on the maximal exercise performance of stable chronic obstructive pulmonary disease patients |
spellingShingle |
The effect of acute magnesium loading on the maximal exercise performance of stable chronic obstructive pulmonary disease patients Amaral, Angélica Florípedes do Pulmonary Disease Chronic Obstructive Magnesium Cardiopulmonary Exercise Test Spirometry Blood Pressure Circulatory and Respiratory Physiology |
title_short |
The effect of acute magnesium loading on the maximal exercise performance of stable chronic obstructive pulmonary disease patients |
title_full |
The effect of acute magnesium loading on the maximal exercise performance of stable chronic obstructive pulmonary disease patients |
title_fullStr |
The effect of acute magnesium loading on the maximal exercise performance of stable chronic obstructive pulmonary disease patients |
title_full_unstemmed |
The effect of acute magnesium loading on the maximal exercise performance of stable chronic obstructive pulmonary disease patients |
title_sort |
The effect of acute magnesium loading on the maximal exercise performance of stable chronic obstructive pulmonary disease patients |
author |
Amaral, Angélica Florípedes do |
author_facet |
Amaral, Angélica Florípedes do Gallo Jr., Lourenco Vannucchi, Hélio Crescêncio, Júlio César Vianna, Elcio Oliveira Martinez, José Antônio Baddini |
author_role |
author |
author2 |
Gallo Jr., Lourenco Vannucchi, Hélio Crescêncio, Júlio César Vianna, Elcio Oliveira Martinez, José Antônio Baddini |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Amaral, Angélica Florípedes do Gallo Jr., Lourenco Vannucchi, Hélio Crescêncio, Júlio César Vianna, Elcio Oliveira Martinez, José Antônio Baddini |
dc.subject.por.fl_str_mv |
Pulmonary Disease Chronic Obstructive Magnesium Cardiopulmonary Exercise Test Spirometry Blood Pressure Circulatory and Respiratory Physiology |
topic |
Pulmonary Disease Chronic Obstructive Magnesium Cardiopulmonary Exercise Test Spirometry Blood Pressure Circulatory and Respiratory Physiology |
description |
OBJECTIVE: The potential influence of magnesium on exercise performance is a subject of increasing interest. Magnesium has been shown to have bronchodilatatory properties in asthma and chronic obstructive pulmonary disease patients. The aim of this study was to investigate the effects of acute magnesium IV loading on the aerobic exercise performance of stable chronic obstructive pulmonary disease patients. METHODS: Twenty male chronic obstructive pulmonary disease patients (66.2 + 8.3 years old, FEV1: 49.3+19.8%) received an IV infusion of 2 g of either magnesium sulfate or saline on two randomly assigned occasions approximately two days apart. Spirometry was performed both before and 45 minutes after the infusions. A symptom-limited incremental maximal cardiopulmonary test was performed on a cycle ergometer at approximately 100 minutes after the end of the infusion. ClinicalTrials.gov: NCT00500864 RESULTS: Magnesium infusion was associated with significant reductions in the functional residual capacity (-0.41 l) and residual volume (-0.47 l), the mean arterial blood pressure (-5.6 mmHg) and the cardiac double product (734.8 mmHg.bpm) at rest. Magnesium treatment led to significant increases in the maximal load reached (+8 w) and the respiratory exchange ratio (0.06) at peak exercise. The subgroup of patients who showed increases in the work load equal to or greater than 5 w also exhibited significantly greater improvements in inspiratory capacity (0.29 l). CONCLUSIONS: The acute IV loading of magnesium promotes a reduction in static lung hyperinflation and improves the exercise performance in stable chronic obstructive pulmonary disease patients. Improvements in respiratory mechanics appear to be responsible for the latter finding. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/40016 10.6061/clinics/2012(06)12 |
url |
https://www.revistas.usp.br/clinics/article/view/40016 |
identifier_str_mv |
10.6061/clinics/2012(06)12 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/40016/42882 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 67 No. 6 (2012); 615-622 Clinics; v. 67 n. 6 (2012); 615-622 Clinics; Vol. 67 Núm. 6 (2012); 615-622 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222758662045696 |