Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/146276 |
Resumo: | Increased stroke risk among chronic obstructive pulmonary disease patients has not yet been established. In this study, we conducted a systematic review and meta-analysis to assess stroke risk among chronic obstructive pulmonary disease patients. PubMed, EMBASE, and the Cochrane Library were systematically searched from database inception until December 31, 2016 to identify longitudinal observational studies that investigated the association between chronic obstructive pulmonary disease and stroke. Stroke risk was quantified by overall and subgroup analyses, and a pooled hazard ratio was calculated. Study quality was evaluated using the Newcastle-Ottawa Scale. Publication bias was assessed using Begg’s rank correlation test. Eight studies met the inclusion criteria. In a random-effects model, significantly increased stroke risk was observed among chronic obstructive pulmonary disease patients (hazard ratio, 1.30; 95% confidence interval, 1.18-1.43). In subgroup analyses stratified by stroke subtype, study quality, and adjustment by socioeconomic status, the association between increased stroke risk and chronic obstructive pulmonary disease patients was robust. Statistically significant publication bias was not detected. In summary, chronic obstructive pulmonary disease was found to be associated with increased stroke risk. Additional prospective studies are required to elucidate the mechanisms underlying the increase in stroke risk and identify effective preventive interventions. |
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Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysisCerebrovascular DiseaseChronic Obstructive Pulmonary DiseaseMeta-AnalysisStrokeIncreased stroke risk among chronic obstructive pulmonary disease patients has not yet been established. In this study, we conducted a systematic review and meta-analysis to assess stroke risk among chronic obstructive pulmonary disease patients. PubMed, EMBASE, and the Cochrane Library were systematically searched from database inception until December 31, 2016 to identify longitudinal observational studies that investigated the association between chronic obstructive pulmonary disease and stroke. Stroke risk was quantified by overall and subgroup analyses, and a pooled hazard ratio was calculated. Study quality was evaluated using the Newcastle-Ottawa Scale. Publication bias was assessed using Begg’s rank correlation test. Eight studies met the inclusion criteria. In a random-effects model, significantly increased stroke risk was observed among chronic obstructive pulmonary disease patients (hazard ratio, 1.30; 95% confidence interval, 1.18-1.43). In subgroup analyses stratified by stroke subtype, study quality, and adjustment by socioeconomic status, the association between increased stroke risk and chronic obstructive pulmonary disease patients was robust. Statistically significant publication bias was not detected. In summary, chronic obstructive pulmonary disease was found to be associated with increased stroke risk. Additional prospective studies are required to elucidate the mechanisms underlying the increase in stroke risk and identify effective preventive interventions.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/14627610.6061/clinics/2018/e177Clinics; Vol. 73 (2018); e177Clinics; v. 73 (2018); e177Clinics; Vol. 73 (2018); e1771980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/146276/139966Copyright (c) 2018 Clinicsinfo:eu-repo/semantics/openAccessKim, Yu ReeHwang, In CheolLee, Yong JooHam, Eun BeePark, Dong KyunKim, Sewan2019-05-14T11:48:50Zoai:revistas.usp.br:article/146276Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-05-14T11:48:50Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis |
title |
Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis |
spellingShingle |
Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis Kim, Yu Ree Cerebrovascular Disease Chronic Obstructive Pulmonary Disease Meta-Analysis Stroke |
title_short |
Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis |
title_full |
Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis |
title_fullStr |
Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis |
title_full_unstemmed |
Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis |
title_sort |
Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis |
author |
Kim, Yu Ree |
author_facet |
Kim, Yu Ree Hwang, In Cheol Lee, Yong Joo Ham, Eun Bee Park, Dong Kyun Kim, Sewan |
author_role |
author |
author2 |
Hwang, In Cheol Lee, Yong Joo Ham, Eun Bee Park, Dong Kyun Kim, Sewan |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Kim, Yu Ree Hwang, In Cheol Lee, Yong Joo Ham, Eun Bee Park, Dong Kyun Kim, Sewan |
dc.subject.por.fl_str_mv |
Cerebrovascular Disease Chronic Obstructive Pulmonary Disease Meta-Analysis Stroke |
topic |
Cerebrovascular Disease Chronic Obstructive Pulmonary Disease Meta-Analysis Stroke |
description |
Increased stroke risk among chronic obstructive pulmonary disease patients has not yet been established. In this study, we conducted a systematic review and meta-analysis to assess stroke risk among chronic obstructive pulmonary disease patients. PubMed, EMBASE, and the Cochrane Library were systematically searched from database inception until December 31, 2016 to identify longitudinal observational studies that investigated the association between chronic obstructive pulmonary disease and stroke. Stroke risk was quantified by overall and subgroup analyses, and a pooled hazard ratio was calculated. Study quality was evaluated using the Newcastle-Ottawa Scale. Publication bias was assessed using Begg’s rank correlation test. Eight studies met the inclusion criteria. In a random-effects model, significantly increased stroke risk was observed among chronic obstructive pulmonary disease patients (hazard ratio, 1.30; 95% confidence interval, 1.18-1.43). In subgroup analyses stratified by stroke subtype, study quality, and adjustment by socioeconomic status, the association between increased stroke risk and chronic obstructive pulmonary disease patients was robust. Statistically significant publication bias was not detected. In summary, chronic obstructive pulmonary disease was found to be associated with increased stroke risk. Additional prospective studies are required to elucidate the mechanisms underlying the increase in stroke risk and identify effective preventive interventions. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/146276 10.6061/clinics/2018/e177 |
url |
https://www.revistas.usp.br/clinics/article/view/146276 |
identifier_str_mv |
10.6061/clinics/2018/e177 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/146276/139966 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 73 (2018); e177 Clinics; v. 73 (2018); e177 Clinics; Vol. 73 (2018); e177 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222763691016192 |