Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/18069 |
Resumo: | INTRODUCTION AND OBJECTIVE: Neoadjuvant and adjuvant therapies for soft tissue sarcomas of the extremities are still controversial. The aim of this study was to analyze the results of a protocol of neoadjuvant chemoradiation therapy for extremity sarcomas. METHODS: A retrospective analysis was carried out in a consecutive series of 49 adult patients with advanced extremity soft tissue sarcomas that could not be resected with adequate margins during the primary resection. All patients were treated with a protocol of preoperative radiation therapy at a total dose of 30 Gy, concomitant with doxorubicin (60 mg/m²) chemotherapy. The main endpoints assessed were local recurrence-free survival, metastasis-free survival and overall survival. The median follow-up time was 32.1 months. RESULTS: The five-year local recurrence-free survival, metastasis-free survival and overall survival rates were 81.5%, 46.7% and 58.3%, respectively. For high-grade tumors, the five-year metastasis-free and overall survival rates were only 36.3% and 41.2%, respectively. Severe wound complications were observed in 41.8% of the patients who underwent surgery. These complications precluded adjuvant chemotherapy in 73.7% (14/19) of the patients eligible to receive it. CONCLUSIONS: In this study, neoadjuvant chemoradiation therapy was associated with a good local control rate, but the distant relapse-free rate and overall survival rate were still poor. The high rate of wound complications modified the planning of adjuvant treatment in most patients. |
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Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities Connective tissue neoplasmsRadiotherapyChemotherapyAdjuvant treatmentSurvival INTRODUCTION AND OBJECTIVE: Neoadjuvant and adjuvant therapies for soft tissue sarcomas of the extremities are still controversial. The aim of this study was to analyze the results of a protocol of neoadjuvant chemoradiation therapy for extremity sarcomas. METHODS: A retrospective analysis was carried out in a consecutive series of 49 adult patients with advanced extremity soft tissue sarcomas that could not be resected with adequate margins during the primary resection. All patients were treated with a protocol of preoperative radiation therapy at a total dose of 30 Gy, concomitant with doxorubicin (60 mg/m²) chemotherapy. The main endpoints assessed were local recurrence-free survival, metastasis-free survival and overall survival. The median follow-up time was 32.1 months. RESULTS: The five-year local recurrence-free survival, metastasis-free survival and overall survival rates were 81.5%, 46.7% and 58.3%, respectively. For high-grade tumors, the five-year metastasis-free and overall survival rates were only 36.3% and 41.2%, respectively. Severe wound complications were observed in 41.8% of the patients who underwent surgery. These complications precluded adjuvant chemotherapy in 73.7% (14/19) of the patients eligible to receive it. CONCLUSIONS: In this study, neoadjuvant chemoradiation therapy was associated with a good local control rate, but the distant relapse-free rate and overall survival rate were still poor. The high rate of wound complications modified the planning of adjuvant treatment in most patients. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2009-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1806910.1590/S1807-59322009001100005Clinics; Vol. 64 No. 11 (2009); 1059-1064 Clinics; v. 64 n. 11 (2009); 1059-1064 Clinics; Vol. 64 Núm. 11 (2009); 1059-1064 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18069/20133Aguiar Junior, SamuelFerreira, Fábio de OliveiraRossi, Benedito MauroSantos, Érika Maria MonteiroSalvajoli, João VictorLopes, Ademarinfo:eu-repo/semantics/openAccess2012-05-22T18:54:09Zoai:revistas.usp.br:article/18069Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:54:09Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities |
title |
Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities |
spellingShingle |
Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities Aguiar Junior, Samuel Connective tissue neoplasms Radiotherapy Chemotherapy Adjuvant treatment Survival |
title_short |
Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities |
title_full |
Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities |
title_fullStr |
Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities |
title_full_unstemmed |
Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities |
title_sort |
Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities |
author |
Aguiar Junior, Samuel |
author_facet |
Aguiar Junior, Samuel Ferreira, Fábio de Oliveira Rossi, Benedito Mauro Santos, Érika Maria Monteiro Salvajoli, João Victor Lopes, Ademar |
author_role |
author |
author2 |
Ferreira, Fábio de Oliveira Rossi, Benedito Mauro Santos, Érika Maria Monteiro Salvajoli, João Victor Lopes, Ademar |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Aguiar Junior, Samuel Ferreira, Fábio de Oliveira Rossi, Benedito Mauro Santos, Érika Maria Monteiro Salvajoli, João Victor Lopes, Ademar |
dc.subject.por.fl_str_mv |
Connective tissue neoplasms Radiotherapy Chemotherapy Adjuvant treatment Survival |
topic |
Connective tissue neoplasms Radiotherapy Chemotherapy Adjuvant treatment Survival |
description |
INTRODUCTION AND OBJECTIVE: Neoadjuvant and adjuvant therapies for soft tissue sarcomas of the extremities are still controversial. The aim of this study was to analyze the results of a protocol of neoadjuvant chemoradiation therapy for extremity sarcomas. METHODS: A retrospective analysis was carried out in a consecutive series of 49 adult patients with advanced extremity soft tissue sarcomas that could not be resected with adequate margins during the primary resection. All patients were treated with a protocol of preoperative radiation therapy at a total dose of 30 Gy, concomitant with doxorubicin (60 mg/m²) chemotherapy. The main endpoints assessed were local recurrence-free survival, metastasis-free survival and overall survival. The median follow-up time was 32.1 months. RESULTS: The five-year local recurrence-free survival, metastasis-free survival and overall survival rates were 81.5%, 46.7% and 58.3%, respectively. For high-grade tumors, the five-year metastasis-free and overall survival rates were only 36.3% and 41.2%, respectively. Severe wound complications were observed in 41.8% of the patients who underwent surgery. These complications precluded adjuvant chemotherapy in 73.7% (14/19) of the patients eligible to receive it. CONCLUSIONS: In this study, neoadjuvant chemoradiation therapy was associated with a good local control rate, but the distant relapse-free rate and overall survival rate were still poor. The high rate of wound complications modified the planning of adjuvant treatment in most patients. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18069 10.1590/S1807-59322009001100005 |
url |
https://www.revistas.usp.br/clinics/article/view/18069 |
identifier_str_mv |
10.1590/S1807-59322009001100005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18069/20133 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 64 No. 11 (2009); 1059-1064 Clinics; v. 64 n. 11 (2009); 1059-1064 Clinics; Vol. 64 Núm. 11 (2009); 1059-1064 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222754800140288 |