Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities

Detalhes bibliográficos
Autor(a) principal: Aguiar Junior, Samuel
Data de Publicação: 2009
Outros Autores: Ferreira, Fábio de Oliveira, Rossi, Benedito Mauro, Santos, Érika Maria Monteiro, Salvajoli, João Victor, Lopes, Ademar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/18069
Resumo: INTRODUCTION AND OBJECTIVE: Neoadjuvant and adjuvant therapies for soft tissue sarcomas of the extremities are still controversial. The aim of this study was to analyze the results of a protocol of neoadjuvant chemoradiation therapy for extremity sarcomas. METHODS: A retrospective analysis was carried out in a consecutive series of 49 adult patients with advanced extremity soft tissue sarcomas that could not be resected with adequate margins during the primary resection. All patients were treated with a protocol of preoperative radiation therapy at a total dose of 30 Gy, concomitant with doxorubicin (60 mg/m²) chemotherapy. The main endpoints assessed were local recurrence-free survival, metastasis-free survival and overall survival. The median follow-up time was 32.1 months. RESULTS: The five-year local recurrence-free survival, metastasis-free survival and overall survival rates were 81.5%, 46.7% and 58.3%, respectively. For high-grade tumors, the five-year metastasis-free and overall survival rates were only 36.3% and 41.2%, respectively. Severe wound complications were observed in 41.8% of the patients who underwent surgery. These complications precluded adjuvant chemotherapy in 73.7% (14/19) of the patients eligible to receive it. CONCLUSIONS: In this study, neoadjuvant chemoradiation therapy was associated with a good local control rate, but the distant relapse-free rate and overall survival rate were still poor. The high rate of wound complications modified the planning of adjuvant treatment in most patients.
id USP-19_74a0cbe5585649c5483c7d2d2dfebc4c
oai_identifier_str oai:revistas.usp.br:article/18069
network_acronym_str USP-19
network_name_str Clinics
repository_id_str
spelling Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities Connective tissue neoplasmsRadiotherapyChemotherapyAdjuvant treatmentSurvival INTRODUCTION AND OBJECTIVE: Neoadjuvant and adjuvant therapies for soft tissue sarcomas of the extremities are still controversial. The aim of this study was to analyze the results of a protocol of neoadjuvant chemoradiation therapy for extremity sarcomas. METHODS: A retrospective analysis was carried out in a consecutive series of 49 adult patients with advanced extremity soft tissue sarcomas that could not be resected with adequate margins during the primary resection. All patients were treated with a protocol of preoperative radiation therapy at a total dose of 30 Gy, concomitant with doxorubicin (60 mg/m²) chemotherapy. The main endpoints assessed were local recurrence-free survival, metastasis-free survival and overall survival. The median follow-up time was 32.1 months. RESULTS: The five-year local recurrence-free survival, metastasis-free survival and overall survival rates were 81.5%, 46.7% and 58.3%, respectively. For high-grade tumors, the five-year metastasis-free and overall survival rates were only 36.3% and 41.2%, respectively. Severe wound complications were observed in 41.8% of the patients who underwent surgery. These complications precluded adjuvant chemotherapy in 73.7% (14/19) of the patients eligible to receive it. CONCLUSIONS: In this study, neoadjuvant chemoradiation therapy was associated with a good local control rate, but the distant relapse-free rate and overall survival rate were still poor. The high rate of wound complications modified the planning of adjuvant treatment in most patients. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2009-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1806910.1590/S1807-59322009001100005Clinics; Vol. 64 No. 11 (2009); 1059-1064 Clinics; v. 64 n. 11 (2009); 1059-1064 Clinics; Vol. 64 Núm. 11 (2009); 1059-1064 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18069/20133Aguiar Junior, SamuelFerreira, Fábio de OliveiraRossi, Benedito MauroSantos, Érika Maria MonteiroSalvajoli, João VictorLopes, Ademarinfo:eu-repo/semantics/openAccess2012-05-22T18:54:09Zoai:revistas.usp.br:article/18069Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:54:09Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities
title Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities
spellingShingle Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities
Aguiar Junior, Samuel
Connective tissue neoplasms
Radiotherapy
Chemotherapy
Adjuvant treatment
Survival
title_short Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities
title_full Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities
title_fullStr Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities
title_full_unstemmed Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities
title_sort Neoadjuvant chemoradiation therapy for soft tissue sarcomas of the extremities
author Aguiar Junior, Samuel
author_facet Aguiar Junior, Samuel
Ferreira, Fábio de Oliveira
Rossi, Benedito Mauro
Santos, Érika Maria Monteiro
Salvajoli, João Victor
Lopes, Ademar
author_role author
author2 Ferreira, Fábio de Oliveira
Rossi, Benedito Mauro
Santos, Érika Maria Monteiro
Salvajoli, João Victor
Lopes, Ademar
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Aguiar Junior, Samuel
Ferreira, Fábio de Oliveira
Rossi, Benedito Mauro
Santos, Érika Maria Monteiro
Salvajoli, João Victor
Lopes, Ademar
dc.subject.por.fl_str_mv Connective tissue neoplasms
Radiotherapy
Chemotherapy
Adjuvant treatment
Survival
topic Connective tissue neoplasms
Radiotherapy
Chemotherapy
Adjuvant treatment
Survival
description INTRODUCTION AND OBJECTIVE: Neoadjuvant and adjuvant therapies for soft tissue sarcomas of the extremities are still controversial. The aim of this study was to analyze the results of a protocol of neoadjuvant chemoradiation therapy for extremity sarcomas. METHODS: A retrospective analysis was carried out in a consecutive series of 49 adult patients with advanced extremity soft tissue sarcomas that could not be resected with adequate margins during the primary resection. All patients were treated with a protocol of preoperative radiation therapy at a total dose of 30 Gy, concomitant with doxorubicin (60 mg/m²) chemotherapy. The main endpoints assessed were local recurrence-free survival, metastasis-free survival and overall survival. The median follow-up time was 32.1 months. RESULTS: The five-year local recurrence-free survival, metastasis-free survival and overall survival rates were 81.5%, 46.7% and 58.3%, respectively. For high-grade tumors, the five-year metastasis-free and overall survival rates were only 36.3% and 41.2%, respectively. Severe wound complications were observed in 41.8% of the patients who underwent surgery. These complications precluded adjuvant chemotherapy in 73.7% (14/19) of the patients eligible to receive it. CONCLUSIONS: In this study, neoadjuvant chemoradiation therapy was associated with a good local control rate, but the distant relapse-free rate and overall survival rate were still poor. The high rate of wound complications modified the planning of adjuvant treatment in most patients.
publishDate 2009
dc.date.none.fl_str_mv 2009-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18069
10.1590/S1807-59322009001100005
url https://www.revistas.usp.br/clinics/article/view/18069
identifier_str_mv 10.1590/S1807-59322009001100005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18069/20133
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 64 No. 11 (2009); 1059-1064
Clinics; v. 64 n. 11 (2009); 1059-1064
Clinics; Vol. 64 Núm. 11 (2009); 1059-1064
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
_version_ 1800222754800140288