Addition of n-butyl cyanoacrylate to classic transarterial chemoembolization may improve the radiological response in patients with hepatocellular carcinoma

Detalhes bibliográficos
Autor(a) principal: Monsignore, Lucas Moretti
Data de Publicação: 2015
Outros Autores: Elias-Junior, Jorge, Muglia, Valdair Francisco, Teixeira, Andreza Correa, Mente, Enio David, Martinelli, Ana de Lourdes Candolo, Abud, Daniel Giansante
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/109994
Resumo: OBJECTIVE: Transarterial chemoembolization is the treatment of choice for intermediate-stage hepatocellular carcinoma. However, there are no clear data supporting transarterial chemoembolization vs . transarterial embolization or regarding the best chemotherapeutic agent, which may suggest a preponderant role of ischemia over chemotherapeutic action. This study sought to evaluate the radiological response and outcome of transarterial chemoembolization modified by n-butyl cyanoacrylate addition compared to conventional transarterial chemoembolization in hepatocellular carcinoma patients. MATERIALS AND METHODS: A retrospective review identified forty-seven patients who underwent modified chemoembolization and thirty-three who underwent conventional chemoembolization between June 2006 and December 2011. The radiological response was reassessed using the modified Response Evaluation Criteria in Solid Tumors. The sustained complete response, time to progression and overall survival rates were also analyzed. RESULTS: Complete response rates were significantly higher in patients who had undergone modified chemoembolization compared to those who had undergone conventional treatment (61.7% and 24.3%, respectively; p
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spelling Addition of n-butyl cyanoacrylate to classic transarterial chemoembolization may improve the radiological response in patients with hepatocellular carcinoma OBJECTIVE: Transarterial chemoembolization is the treatment of choice for intermediate-stage hepatocellular carcinoma. However, there are no clear data supporting transarterial chemoembolization vs . transarterial embolization or regarding the best chemotherapeutic agent, which may suggest a preponderant role of ischemia over chemotherapeutic action. This study sought to evaluate the radiological response and outcome of transarterial chemoembolization modified by n-butyl cyanoacrylate addition compared to conventional transarterial chemoembolization in hepatocellular carcinoma patients. MATERIALS AND METHODS: A retrospective review identified forty-seven patients who underwent modified chemoembolization and thirty-three who underwent conventional chemoembolization between June 2006 and December 2011. The radiological response was reassessed using the modified Response Evaluation Criteria in Solid Tumors. The sustained complete response, time to progression and overall survival rates were also analyzed. RESULTS: Complete response rates were significantly higher in patients who had undergone modified chemoembolization compared to those who had undergone conventional treatment (61.7% and 24.3%, respectively; p Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/10999410.6061/clinics/2015(12)04Clinics; Vol. 70 No. 12 (2015); 781-789Clinics; v. 70 n. 12 (2015); 781-789Clinics; Vol. 70 Núm. 12 (2015); 781-7891980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/109994/108598Copyright (c) 2016 Clinicsinfo:eu-repo/semantics/openAccessMonsignore, Lucas MorettiElias-Junior, JorgeMuglia, Valdair FranciscoTeixeira, Andreza CorreaMente, Enio DavidMartinelli, Ana de Lourdes CandoloAbud, Daniel Giansante2016-01-19T10:57:42Zoai:revistas.usp.br:article/109994Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2016-01-19T10:57:42Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Addition of n-butyl cyanoacrylate to classic transarterial chemoembolization may improve the radiological response in patients with hepatocellular carcinoma
title Addition of n-butyl cyanoacrylate to classic transarterial chemoembolization may improve the radiological response in patients with hepatocellular carcinoma
spellingShingle Addition of n-butyl cyanoacrylate to classic transarterial chemoembolization may improve the radiological response in patients with hepatocellular carcinoma
Monsignore, Lucas Moretti
title_short Addition of n-butyl cyanoacrylate to classic transarterial chemoembolization may improve the radiological response in patients with hepatocellular carcinoma
title_full Addition of n-butyl cyanoacrylate to classic transarterial chemoembolization may improve the radiological response in patients with hepatocellular carcinoma
title_fullStr Addition of n-butyl cyanoacrylate to classic transarterial chemoembolization may improve the radiological response in patients with hepatocellular carcinoma
title_full_unstemmed Addition of n-butyl cyanoacrylate to classic transarterial chemoembolization may improve the radiological response in patients with hepatocellular carcinoma
title_sort Addition of n-butyl cyanoacrylate to classic transarterial chemoembolization may improve the radiological response in patients with hepatocellular carcinoma
author Monsignore, Lucas Moretti
author_facet Monsignore, Lucas Moretti
Elias-Junior, Jorge
Muglia, Valdair Francisco
Teixeira, Andreza Correa
Mente, Enio David
Martinelli, Ana de Lourdes Candolo
Abud, Daniel Giansante
author_role author
author2 Elias-Junior, Jorge
Muglia, Valdair Francisco
Teixeira, Andreza Correa
Mente, Enio David
Martinelli, Ana de Lourdes Candolo
Abud, Daniel Giansante
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Monsignore, Lucas Moretti
Elias-Junior, Jorge
Muglia, Valdair Francisco
Teixeira, Andreza Correa
Mente, Enio David
Martinelli, Ana de Lourdes Candolo
Abud, Daniel Giansante
description OBJECTIVE: Transarterial chemoembolization is the treatment of choice for intermediate-stage hepatocellular carcinoma. However, there are no clear data supporting transarterial chemoembolization vs . transarterial embolization or regarding the best chemotherapeutic agent, which may suggest a preponderant role of ischemia over chemotherapeutic action. This study sought to evaluate the radiological response and outcome of transarterial chemoembolization modified by n-butyl cyanoacrylate addition compared to conventional transarterial chemoembolization in hepatocellular carcinoma patients. MATERIALS AND METHODS: A retrospective review identified forty-seven patients who underwent modified chemoembolization and thirty-three who underwent conventional chemoembolization between June 2006 and December 2011. The radiological response was reassessed using the modified Response Evaluation Criteria in Solid Tumors. The sustained complete response, time to progression and overall survival rates were also analyzed. RESULTS: Complete response rates were significantly higher in patients who had undergone modified chemoembolization compared to those who had undergone conventional treatment (61.7% and 24.3%, respectively; p
publishDate 2015
dc.date.none.fl_str_mv 2015-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/109994
10.6061/clinics/2015(12)04
url https://www.revistas.usp.br/clinics/article/view/109994
identifier_str_mv 10.6061/clinics/2015(12)04
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/109994/108598
dc.rights.driver.fl_str_mv Copyright (c) 2016 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2016 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 70 No. 12 (2015); 781-789
Clinics; v. 70 n. 12 (2015); 781-789
Clinics; Vol. 70 Núm. 12 (2015); 781-789
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
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