Nutritional profile of newborns with microcephaly and factors associated with worse outcomes
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/163617 |
Resumo: | OBJECTIVE: To describe the nutritional profile of newborns with microcephaly and factors associated with worse outcomes during the first 14 days of life. METHODS: This investigation is a longitudinal, descriptive study carried out in 21 full-term neonates exposed vertically to the Zika virus and hospitalized in a neonatal intensive care unit from February to September 2016. Patients receiving parenteral nutrition were excluded. Data analysis was performed using a generalized estimating equation model and Student’s t-test to evaluate the association between worsening weight-for-age z-scores and independent clinical, sociodemographic and nutritional variables during hospitalization, with po0.05 indicating significance. RESULTS: During hospitalization, there was a decrease in the mean values of the weight-for-age z-scores. The factors associated with worse nutritional outcomes were symptomatic exposure to the Zika virus, low maternal schooling, absence of maternal income and consumption of infant formula (po0.05). Calcification and severe microcephaly were also associated with poor nutritional outcomes. Energy and macronutrient consumption remained below the recommendations and had an upward trend during hospitalization. CONCLUSION: The presence of cerebral calcification, the severity of microcephaly and symptomatic maternal exposure to Zika virus affected the nutritional status of newborns. In terms of nutritional factors, human milk intake had a positive impact, reducing weight loss in the first days of life. Other known factors, such as income and maternal schooling, were still associated with a poor nutritional status. |
id |
USP-19_772ea093f999c3955163e228d47dbfd7 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/163617 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
Nutritional profile of newborns with microcephaly and factors associated with worse outcomesZika VirusMicrocephalyNutritional StatusNewbornOBJECTIVE: To describe the nutritional profile of newborns with microcephaly and factors associated with worse outcomes during the first 14 days of life. METHODS: This investigation is a longitudinal, descriptive study carried out in 21 full-term neonates exposed vertically to the Zika virus and hospitalized in a neonatal intensive care unit from February to September 2016. Patients receiving parenteral nutrition were excluded. Data analysis was performed using a generalized estimating equation model and Student’s t-test to evaluate the association between worsening weight-for-age z-scores and independent clinical, sociodemographic and nutritional variables during hospitalization, with po0.05 indicating significance. RESULTS: During hospitalization, there was a decrease in the mean values of the weight-for-age z-scores. The factors associated with worse nutritional outcomes were symptomatic exposure to the Zika virus, low maternal schooling, absence of maternal income and consumption of infant formula (po0.05). Calcification and severe microcephaly were also associated with poor nutritional outcomes. Energy and macronutrient consumption remained below the recommendations and had an upward trend during hospitalization. CONCLUSION: The presence of cerebral calcification, the severity of microcephaly and symptomatic maternal exposure to Zika virus affected the nutritional status of newborns. In terms of nutritional factors, human milk intake had a positive impact, reducing weight loss in the first days of life. Other known factors, such as income and maternal schooling, were still associated with a poor nutritional status.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-10-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/16361710.6061/clinics/2019/e798Clinics; v. 74 (2019); e798Clinics; Vol. 74 (2019); e798Clinics; Vol. 74 (2019); e7981980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/163617/157229https://www.revistas.usp.br/clinics/article/view/163617/157230Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessSantos, Samira Fernandes Morais dosSoares, Fernanda Valente MendesAbranches, Andrea Dunshee deCosta, Ana Carolina Carioca daGomes-Júnior, Saint Clair dos SantosFonseca, Vania de MatosMoreira, Maria Elisabeth Lopes2019-10-29T14:18:31Zoai:revistas.usp.br:article/163617Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-10-29T14:18:31Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Nutritional profile of newborns with microcephaly and factors associated with worse outcomes |
title |
Nutritional profile of newborns with microcephaly and factors associated with worse outcomes |
spellingShingle |
Nutritional profile of newborns with microcephaly and factors associated with worse outcomes Santos, Samira Fernandes Morais dos Zika Virus Microcephaly Nutritional Status Newborn |
title_short |
Nutritional profile of newborns with microcephaly and factors associated with worse outcomes |
title_full |
Nutritional profile of newborns with microcephaly and factors associated with worse outcomes |
title_fullStr |
Nutritional profile of newborns with microcephaly and factors associated with worse outcomes |
title_full_unstemmed |
Nutritional profile of newborns with microcephaly and factors associated with worse outcomes |
title_sort |
Nutritional profile of newborns with microcephaly and factors associated with worse outcomes |
author |
Santos, Samira Fernandes Morais dos |
author_facet |
Santos, Samira Fernandes Morais dos Soares, Fernanda Valente Mendes Abranches, Andrea Dunshee de Costa, Ana Carolina Carioca da Gomes-Júnior, Saint Clair dos Santos Fonseca, Vania de Matos Moreira, Maria Elisabeth Lopes |
author_role |
author |
author2 |
Soares, Fernanda Valente Mendes Abranches, Andrea Dunshee de Costa, Ana Carolina Carioca da Gomes-Júnior, Saint Clair dos Santos Fonseca, Vania de Matos Moreira, Maria Elisabeth Lopes |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Samira Fernandes Morais dos Soares, Fernanda Valente Mendes Abranches, Andrea Dunshee de Costa, Ana Carolina Carioca da Gomes-Júnior, Saint Clair dos Santos Fonseca, Vania de Matos Moreira, Maria Elisabeth Lopes |
dc.subject.por.fl_str_mv |
Zika Virus Microcephaly Nutritional Status Newborn |
topic |
Zika Virus Microcephaly Nutritional Status Newborn |
description |
OBJECTIVE: To describe the nutritional profile of newborns with microcephaly and factors associated with worse outcomes during the first 14 days of life. METHODS: This investigation is a longitudinal, descriptive study carried out in 21 full-term neonates exposed vertically to the Zika virus and hospitalized in a neonatal intensive care unit from February to September 2016. Patients receiving parenteral nutrition were excluded. Data analysis was performed using a generalized estimating equation model and Student’s t-test to evaluate the association between worsening weight-for-age z-scores and independent clinical, sociodemographic and nutritional variables during hospitalization, with po0.05 indicating significance. RESULTS: During hospitalization, there was a decrease in the mean values of the weight-for-age z-scores. The factors associated with worse nutritional outcomes were symptomatic exposure to the Zika virus, low maternal schooling, absence of maternal income and consumption of infant formula (po0.05). Calcification and severe microcephaly were also associated with poor nutritional outcomes. Energy and macronutrient consumption remained below the recommendations and had an upward trend during hospitalization. CONCLUSION: The presence of cerebral calcification, the severity of microcephaly and symptomatic maternal exposure to Zika virus affected the nutritional status of newborns. In terms of nutritional factors, human milk intake had a positive impact, reducing weight loss in the first days of life. Other known factors, such as income and maternal schooling, were still associated with a poor nutritional status. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/163617 10.6061/clinics/2019/e798 |
url |
https://www.revistas.usp.br/clinics/article/view/163617 |
identifier_str_mv |
10.6061/clinics/2019/e798 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/163617/157229 https://www.revistas.usp.br/clinics/article/view/163617/157230 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; v. 74 (2019); e798 Clinics; Vol. 74 (2019); e798 Clinics; Vol. 74 (2019); e798 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1787713181453385728 |