The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/117969 |
Resumo: | OBJECTIVE: The aim of the present study was to assess nasal mucociliary clearance, mucus properties and inflammation in smokers and subjects enrolled in a Smoking Cessation Program (referred to as quitters). METHOD: A total of 33 subjects with a median (IQR) smoking history of 34 (20-58) pack years were examined for nasal mucociliary clearance using a saccharine transit test, mucus properties using contact angle and sneeze clearability tests, and quantification of inflammatory and epithelial cells, IL-6 and IL-8 concentrations in nasal lavage fluid. Twenty quitters (mean age: 51 years, 9 male) were assessed at baseline, 1 month, 3 months and 12 months after smoking cessation, and 13 smokers (mean age: 52 years, 6 male) were assessed at baseline and after 12 months. Clinicaltrials.gov: NCT02136550. RESULTS: Smokers and quitters showed similar demographic characteristics and morbidities. At baseline, all subjects showed impaired nasal mucociliary clearance (mean 17.6 min), although 63% and 85% of the quitters demonstrated significant nasal mucociliary clearance improvement at 1 month and 12 months, respectively. At 12 months, quitters also showed mucus sneeze clearability improvement (∼26%), an increased number of macrophages (2-fold) and no changes in mucus contact angle or cytokine concentrations. CONCLUSION: This study showed that smoking cessation induced early improvements in nasal mucociliary clearance independent of mucus properties and inflammation. Changes in mucus properties were observed after only 12 months of smoking cessation. |
id |
USP-19_795efa9230301b171856ecd08295c009 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/117969 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation OBJECTIVE: The aim of the present study was to assess nasal mucociliary clearance, mucus properties and inflammation in smokers and subjects enrolled in a Smoking Cessation Program (referred to as quitters). METHOD: A total of 33 subjects with a median (IQR) smoking history of 34 (20-58) pack years were examined for nasal mucociliary clearance using a saccharine transit test, mucus properties using contact angle and sneeze clearability tests, and quantification of inflammatory and epithelial cells, IL-6 and IL-8 concentrations in nasal lavage fluid. Twenty quitters (mean age: 51 years, 9 male) were assessed at baseline, 1 month, 3 months and 12 months after smoking cessation, and 13 smokers (mean age: 52 years, 6 male) were assessed at baseline and after 12 months. Clinicaltrials.gov: NCT02136550. RESULTS: Smokers and quitters showed similar demographic characteristics and morbidities. At baseline, all subjects showed impaired nasal mucociliary clearance (mean 17.6 min), although 63% and 85% of the quitters demonstrated significant nasal mucociliary clearance improvement at 1 month and 12 months, respectively. At 12 months, quitters also showed mucus sneeze clearability improvement (∼26%), an increased number of macrophages (2-fold) and no changes in mucus contact angle or cytokine concentrations. CONCLUSION: This study showed that smoking cessation induced early improvements in nasal mucociliary clearance independent of mucus properties and inflammation. Changes in mucus properties were observed after only 12 months of smoking cessation. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/11796910.6061/clinics/2016(06)10Clinics; Vol. 71 No. 6 (2016); 344-350Clinics; v. 71 n. 6 (2016); 344-350Clinics; Vol. 71 Núm. 6 (2016); 344-3501980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/117969/115614Copyright (c) 2016 Clinicsinfo:eu-repo/semantics/openAccessUtiyama, Daniela Mitiyo OdagiriYoshida, Carolina TiekoGoto, Danielle Miyukide Santana Carvalho, Tômasde Paula Santos, UbiratanKoczulla, Andreas RembertSaldiva, Paulo Hilário NascimentoNakagawa, Naomi Kondo2016-07-19T19:47:01Zoai:revistas.usp.br:article/117969Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2016-07-19T19:47:01Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation |
title |
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation |
spellingShingle |
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation Utiyama, Daniela Mitiyo Odagiri |
title_short |
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation |
title_full |
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation |
title_fullStr |
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation |
title_full_unstemmed |
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation |
title_sort |
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation |
author |
Utiyama, Daniela Mitiyo Odagiri |
author_facet |
Utiyama, Daniela Mitiyo Odagiri Yoshida, Carolina Tieko Goto, Danielle Miyuki de Santana Carvalho, Tômas de Paula Santos, Ubiratan Koczulla, Andreas Rembert Saldiva, Paulo Hilário Nascimento Nakagawa, Naomi Kondo |
author_role |
author |
author2 |
Yoshida, Carolina Tieko Goto, Danielle Miyuki de Santana Carvalho, Tômas de Paula Santos, Ubiratan Koczulla, Andreas Rembert Saldiva, Paulo Hilário Nascimento Nakagawa, Naomi Kondo |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Utiyama, Daniela Mitiyo Odagiri Yoshida, Carolina Tieko Goto, Danielle Miyuki de Santana Carvalho, Tômas de Paula Santos, Ubiratan Koczulla, Andreas Rembert Saldiva, Paulo Hilário Nascimento Nakagawa, Naomi Kondo |
description |
OBJECTIVE: The aim of the present study was to assess nasal mucociliary clearance, mucus properties and inflammation in smokers and subjects enrolled in a Smoking Cessation Program (referred to as quitters). METHOD: A total of 33 subjects with a median (IQR) smoking history of 34 (20-58) pack years were examined for nasal mucociliary clearance using a saccharine transit test, mucus properties using contact angle and sneeze clearability tests, and quantification of inflammatory and epithelial cells, IL-6 and IL-8 concentrations in nasal lavage fluid. Twenty quitters (mean age: 51 years, 9 male) were assessed at baseline, 1 month, 3 months and 12 months after smoking cessation, and 13 smokers (mean age: 52 years, 6 male) were assessed at baseline and after 12 months. Clinicaltrials.gov: NCT02136550. RESULTS: Smokers and quitters showed similar demographic characteristics and morbidities. At baseline, all subjects showed impaired nasal mucociliary clearance (mean 17.6 min), although 63% and 85% of the quitters demonstrated significant nasal mucociliary clearance improvement at 1 month and 12 months, respectively. At 12 months, quitters also showed mucus sneeze clearability improvement (∼26%), an increased number of macrophages (2-fold) and no changes in mucus contact angle or cytokine concentrations. CONCLUSION: This study showed that smoking cessation induced early improvements in nasal mucociliary clearance independent of mucus properties and inflammation. Changes in mucus properties were observed after only 12 months of smoking cessation. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/117969 10.6061/clinics/2016(06)10 |
url |
https://www.revistas.usp.br/clinics/article/view/117969 |
identifier_str_mv |
10.6061/clinics/2016(06)10 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/117969/115614 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2016 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2016 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 71 No. 6 (2016); 344-350 Clinics; v. 71 n. 6 (2016); 344-350 Clinics; Vol. 71 Núm. 6 (2016); 344-350 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222762637197312 |