99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Monica Pires
Data de Publicação: 2013
Outros Autores: Souza, Sergio Augusto Lopes de, Lopes, Flavia Paiva Proenca Lobo, Rosado-de-Castro, Paulo Henrique, Fonseca, Lea Mirian Barbosa da, Gutfilen, Bianca
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/72123
Resumo: OBJECTIVE: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its sensitivity and specificity. The objective of this study with breast scintigraphy was to evaluate the uptake of 99mTc-thymine in mammary lesions. METHODS: A total of 45 patients were included in this study. Thirty-three patients (73%) were subjected to surgery or percutaneous biopsy, providing histopathological data. The other 12 patients who remained under surveillance received clinical examinations and biannual mammography with a normal follow-up of at least three years, the data from which were used for comparison with the scintimammography results. RESULTS: The majority of patients (64.4%) had clinically impalpable lesions with a mammogram diagnosis of microcalcifications, impalpable nodules, or focal asymmetry. Of the studied lesions, 87% were smaller or equal to 20 mm in diameter, and 22% had malignant histopathological findings. Scintigraphy with 99mTc-thymine had a sensitivity of 70%, a specificity of 85.7%, positive and negative predictive values of 58.3% and 90.9%, respectively, and an accuracy of 82.2%. CONCLUSIONS: The results of this study are consistent with those previously reported by other authors. The good specificity and high negative predictive value of this technique and the absence of uptake in the heart indicate that it may be a promising complementary method in clinical practice and that it may contribute to reducing unnecessary benign biopsies.
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spelling 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancerBreast Scintigraphy99mTc-thymineBreast CancerOBJECTIVE: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its sensitivity and specificity. The objective of this study with breast scintigraphy was to evaluate the uptake of 99mTc-thymine in mammary lesions. METHODS: A total of 45 patients were included in this study. Thirty-three patients (73%) were subjected to surgery or percutaneous biopsy, providing histopathological data. The other 12 patients who remained under surveillance received clinical examinations and biannual mammography with a normal follow-up of at least three years, the data from which were used for comparison with the scintimammography results. RESULTS: The majority of patients (64.4%) had clinically impalpable lesions with a mammogram diagnosis of microcalcifications, impalpable nodules, or focal asymmetry. Of the studied lesions, 87% were smaller or equal to 20 mm in diameter, and 22% had malignant histopathological findings. Scintigraphy with 99mTc-thymine had a sensitivity of 70%, a specificity of 85.7%, positive and negative predictive values of 58.3% and 90.9%, respectively, and an accuracy of 82.2%. CONCLUSIONS: The results of this study are consistent with those previously reported by other authors. The good specificity and high negative predictive value of this technique and the absence of uptake in the heart indicate that it may be a promising complementary method in clinical practice and that it may contribute to reducing unnecessary benign biopsies.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/7212310.1590/clin.v68i3.72123Clinics; Vol. 68 No. 3 (2013); 283-289Clinics; v. 68 n. 3 (2013); 283-289Clinics; Vol. 68 Núm. 3 (2013); 283-2891980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/72123/75358Ribeiro, Monica PiresSouza, Sergio Augusto Lopes deLopes, Flavia Paiva Proenca LoboRosado-de-Castro, Paulo HenriqueFonseca, Lea Mirian Barbosa daGutfilen, Biancainfo:eu-repo/semantics/openAccess2014-01-28T17:05:36Zoai:revistas.usp.br:article/72123Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2014-01-28T17:05:36Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
title 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
spellingShingle 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
Ribeiro, Monica Pires
Breast Scintigraphy
99mTc-thymine
Breast Cancer
title_short 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
title_full 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
title_fullStr 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
title_full_unstemmed 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
title_sort 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer
author Ribeiro, Monica Pires
author_facet Ribeiro, Monica Pires
Souza, Sergio Augusto Lopes de
Lopes, Flavia Paiva Proenca Lobo
Rosado-de-Castro, Paulo Henrique
Fonseca, Lea Mirian Barbosa da
Gutfilen, Bianca
author_role author
author2 Souza, Sergio Augusto Lopes de
Lopes, Flavia Paiva Proenca Lobo
Rosado-de-Castro, Paulo Henrique
Fonseca, Lea Mirian Barbosa da
Gutfilen, Bianca
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro, Monica Pires
Souza, Sergio Augusto Lopes de
Lopes, Flavia Paiva Proenca Lobo
Rosado-de-Castro, Paulo Henrique
Fonseca, Lea Mirian Barbosa da
Gutfilen, Bianca
dc.subject.por.fl_str_mv Breast Scintigraphy
99mTc-thymine
Breast Cancer
topic Breast Scintigraphy
99mTc-thymine
Breast Cancer
description OBJECTIVE: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its sensitivity and specificity. The objective of this study with breast scintigraphy was to evaluate the uptake of 99mTc-thymine in mammary lesions. METHODS: A total of 45 patients were included in this study. Thirty-three patients (73%) were subjected to surgery or percutaneous biopsy, providing histopathological data. The other 12 patients who remained under surveillance received clinical examinations and biannual mammography with a normal follow-up of at least three years, the data from which were used for comparison with the scintimammography results. RESULTS: The majority of patients (64.4%) had clinically impalpable lesions with a mammogram diagnosis of microcalcifications, impalpable nodules, or focal asymmetry. Of the studied lesions, 87% were smaller or equal to 20 mm in diameter, and 22% had malignant histopathological findings. Scintigraphy with 99mTc-thymine had a sensitivity of 70%, a specificity of 85.7%, positive and negative predictive values of 58.3% and 90.9%, respectively, and an accuracy of 82.2%. CONCLUSIONS: The results of this study are consistent with those previously reported by other authors. The good specificity and high negative predictive value of this technique and the absence of uptake in the heart indicate that it may be a promising complementary method in clinical practice and that it may contribute to reducing unnecessary benign biopsies.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/72123
10.1590/clin.v68i3.72123
url https://www.revistas.usp.br/clinics/article/view/72123
identifier_str_mv 10.1590/clin.v68i3.72123
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/72123/75358
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 68 No. 3 (2013); 283-289
Clinics; v. 68 n. 3 (2013); 283-289
Clinics; Vol. 68 Núm. 3 (2013); 283-289
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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