Fetuin-A levels in hyperthyroidism
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/72137 |
Resumo: | OBJECTIVE: Fetuin-A is a protein secreted from the liver that inhibits arterial calcification deposition and can contribute to insulin resistance. Hyperthyroidism is also associated with insulin resistance. It is not known whether hyperthyroidism has an effect on fetuin-A levels. METHODS: We measured fetuin-A levels and homeostasis model of assessment-insulin resistance before hyperthyroidism treatment was initiated and after euthyroidism was achieved. A total of 42 patients diagnosed with hyperthyroidism were enrolled in this study. Fetuin-A, insulin, high-sensitivity C-reactive protein, fasting blood glucose, free T3 (fT3), free T4 (fT4), and thyrotropin were measured before and after euthyroidism was established. RESULTS: Basal fasting blood glucose, high-sensitivity C-reactive protein, insulin, c-peptide, homeostasis model of assessment-insulin resistance, fT3, fT4 and fetuin-A levels were significantly decreased after euthyroidism was achieved (Table 1). Basal fasting blood glucose (r:0.407, p:0.008), high-sensitivity C-reactive protein (r:0.523, p |
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Clinics |
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|
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Fetuin-A levels in hyperthyroidismFetuin-AHyperthyroidismInsulin ResistanceOBJECTIVE: Fetuin-A is a protein secreted from the liver that inhibits arterial calcification deposition and can contribute to insulin resistance. Hyperthyroidism is also associated with insulin resistance. It is not known whether hyperthyroidism has an effect on fetuin-A levels. METHODS: We measured fetuin-A levels and homeostasis model of assessment-insulin resistance before hyperthyroidism treatment was initiated and after euthyroidism was achieved. A total of 42 patients diagnosed with hyperthyroidism were enrolled in this study. Fetuin-A, insulin, high-sensitivity C-reactive protein, fasting blood glucose, free T3 (fT3), free T4 (fT4), and thyrotropin were measured before and after euthyroidism was established. RESULTS: Basal fasting blood glucose, high-sensitivity C-reactive protein, insulin, c-peptide, homeostasis model of assessment-insulin resistance, fT3, fT4 and fetuin-A levels were significantly decreased after euthyroidism was achieved (Table 1). Basal fasting blood glucose (r:0.407, p:0.008), high-sensitivity C-reactive protein (r:0.523, pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/7213710.1590/clin.v68i3.72137Clinics; Vol. 68 No. 3 (2013); 379-383Clinics; v. 68 n. 3 (2013); 379-383Clinics; Vol. 68 Núm. 3 (2013); 379-3831980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/72137/75372Pamuk, Bariş OnderYilmaz, HamiyetTopcuoglu, TugbaBilgir, OktayÇalan, OzlemPamuk, GulserenErtugrul, Derun Tanerinfo:eu-repo/semantics/openAccess2014-01-28T17:05:37Zoai:revistas.usp.br:article/72137Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2014-01-28T17:05:37Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Fetuin-A levels in hyperthyroidism |
title |
Fetuin-A levels in hyperthyroidism |
spellingShingle |
Fetuin-A levels in hyperthyroidism Pamuk, Bariş Onder Fetuin-A Hyperthyroidism Insulin Resistance |
title_short |
Fetuin-A levels in hyperthyroidism |
title_full |
Fetuin-A levels in hyperthyroidism |
title_fullStr |
Fetuin-A levels in hyperthyroidism |
title_full_unstemmed |
Fetuin-A levels in hyperthyroidism |
title_sort |
Fetuin-A levels in hyperthyroidism |
author |
Pamuk, Bariş Onder |
author_facet |
Pamuk, Bariş Onder Yilmaz, Hamiyet Topcuoglu, Tugba Bilgir, Oktay Çalan, Ozlem Pamuk, Gulseren Ertugrul, Derun Taner |
author_role |
author |
author2 |
Yilmaz, Hamiyet Topcuoglu, Tugba Bilgir, Oktay Çalan, Ozlem Pamuk, Gulseren Ertugrul, Derun Taner |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Pamuk, Bariş Onder Yilmaz, Hamiyet Topcuoglu, Tugba Bilgir, Oktay Çalan, Ozlem Pamuk, Gulseren Ertugrul, Derun Taner |
dc.subject.por.fl_str_mv |
Fetuin-A Hyperthyroidism Insulin Resistance |
topic |
Fetuin-A Hyperthyroidism Insulin Resistance |
description |
OBJECTIVE: Fetuin-A is a protein secreted from the liver that inhibits arterial calcification deposition and can contribute to insulin resistance. Hyperthyroidism is also associated with insulin resistance. It is not known whether hyperthyroidism has an effect on fetuin-A levels. METHODS: We measured fetuin-A levels and homeostasis model of assessment-insulin resistance before hyperthyroidism treatment was initiated and after euthyroidism was achieved. A total of 42 patients diagnosed with hyperthyroidism were enrolled in this study. Fetuin-A, insulin, high-sensitivity C-reactive protein, fasting blood glucose, free T3 (fT3), free T4 (fT4), and thyrotropin were measured before and after euthyroidism was established. RESULTS: Basal fasting blood glucose, high-sensitivity C-reactive protein, insulin, c-peptide, homeostasis model of assessment-insulin resistance, fT3, fT4 and fetuin-A levels were significantly decreased after euthyroidism was achieved (Table 1). Basal fasting blood glucose (r:0.407, p:0.008), high-sensitivity C-reactive protein (r:0.523, p |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/72137 10.1590/clin.v68i3.72137 |
url |
https://www.revistas.usp.br/clinics/article/view/72137 |
identifier_str_mv |
10.1590/clin.v68i3.72137 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/72137/75372 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 68 No. 3 (2013); 379-383 Clinics; v. 68 n. 3 (2013); 379-383 Clinics; Vol. 68 Núm. 3 (2013); 379-383 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222759809187840 |