Circulating microparticles and central blood pressure according to antihypertensive strategy
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/164160 |
Resumo: | OBJECTIVES: This prospective, randomized, open-label study aimed to compare the effects of antihypertensive treatment based on amlodipine or hydrochlorothiazide on the circulating microparticles and central blood pressure values of hypertensive patients. METHODS: The effects of treatments on circulating microparticles were assessed during monotherapy and after the consecutive addition of valsartan and rosuvastatin followed by the withdrawal of rosuvastatin. Each treatment period lasted for 30 days. Central blood pressure and pulse wave velocity were measured at the end of each period. Endothelial, monocyte, and platelet circulating microparticles were determined by flow cytometry. Central blood pressure values and pulse wave velocity were recorded at the end of each treatment period. RESULTS: No differences in brachial blood pressure were observed between the treatment groups throughout the study. Although similar central blood pressure values were observed during monotherapy, lower systolic and diastolic central blood pressure values and early and late blood pressure peaks were observed in the amlodipine arm after the addition of valsartan alone or combined with rosuvastatin. Hydrochlorothiazide-based therapy was associated with a lower number of endothelial microparticles throughout the study, whereas a higher number of platelet microparticles was observed after rosuvastatin withdrawal in the amlodipine arm. CONCLUSIONS: Despite similar brachial blood pressure values between groups throughout the study, exposure to amlodipine was associated with lower central blood pressure values after combination with valsartan, indicating a beneficial interaction. Differences between circulating microparticles were modest and were mainly influenced by rosuvastatin withdrawal in the amlodipine arm. |
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Clinics |
repository_id_str |
|
spelling |
Circulating microparticles and central blood pressure according to antihypertensive strategyEndothelial MicroparticlesMonocyte MicroparticlesPlatelet MicroparticlesCentral Blood PressureHydrochlorothiazideAmlodipineOBJECTIVES: This prospective, randomized, open-label study aimed to compare the effects of antihypertensive treatment based on amlodipine or hydrochlorothiazide on the circulating microparticles and central blood pressure values of hypertensive patients. METHODS: The effects of treatments on circulating microparticles were assessed during monotherapy and after the consecutive addition of valsartan and rosuvastatin followed by the withdrawal of rosuvastatin. Each treatment period lasted for 30 days. Central blood pressure and pulse wave velocity were measured at the end of each period. Endothelial, monocyte, and platelet circulating microparticles were determined by flow cytometry. Central blood pressure values and pulse wave velocity were recorded at the end of each treatment period. RESULTS: No differences in brachial blood pressure were observed between the treatment groups throughout the study. Although similar central blood pressure values were observed during monotherapy, lower systolic and diastolic central blood pressure values and early and late blood pressure peaks were observed in the amlodipine arm after the addition of valsartan alone or combined with rosuvastatin. Hydrochlorothiazide-based therapy was associated with a lower number of endothelial microparticles throughout the study, whereas a higher number of platelet microparticles was observed after rosuvastatin withdrawal in the amlodipine arm. CONCLUSIONS: Despite similar brachial blood pressure values between groups throughout the study, exposure to amlodipine was associated with lower central blood pressure values after combination with valsartan, indicating a beneficial interaction. Differences between circulating microparticles were modest and were mainly influenced by rosuvastatin withdrawal in the amlodipine arm.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-11-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/16416010.6061/clinics/2019/e1234Clinics; Vol. 74 (2019); e1234Clinics; v. 74 (2019); e1234Clinics; Vol. 74 (2019); e12341980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/164160/157552https://www.revistas.usp.br/clinics/article/view/164160/157553Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessMassunaga, Nayara D.França, Carolina N.Bianco, Henrique T.Ferreira, Carlos E.S.Kato, Juliana T.Póvoa, Rui M.S.Figueiredo Neto, Antonio M.Izar, Maria Cristina O.Fonseca, Francisco Antonio Helfenstein2019-11-18T12:51:45Zoai:revistas.usp.br:article/164160Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-11-18T12:51:45Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Circulating microparticles and central blood pressure according to antihypertensive strategy |
title |
Circulating microparticles and central blood pressure according to antihypertensive strategy |
spellingShingle |
Circulating microparticles and central blood pressure according to antihypertensive strategy Massunaga, Nayara D. Endothelial Microparticles Monocyte Microparticles Platelet Microparticles Central Blood Pressure Hydrochlorothiazide Amlodipine |
title_short |
Circulating microparticles and central blood pressure according to antihypertensive strategy |
title_full |
Circulating microparticles and central blood pressure according to antihypertensive strategy |
title_fullStr |
Circulating microparticles and central blood pressure according to antihypertensive strategy |
title_full_unstemmed |
Circulating microparticles and central blood pressure according to antihypertensive strategy |
title_sort |
Circulating microparticles and central blood pressure according to antihypertensive strategy |
author |
Massunaga, Nayara D. |
author_facet |
Massunaga, Nayara D. França, Carolina N. Bianco, Henrique T. Ferreira, Carlos E.S. Kato, Juliana T. Póvoa, Rui M.S. Figueiredo Neto, Antonio M. Izar, Maria Cristina O. Fonseca, Francisco Antonio Helfenstein |
author_role |
author |
author2 |
França, Carolina N. Bianco, Henrique T. Ferreira, Carlos E.S. Kato, Juliana T. Póvoa, Rui M.S. Figueiredo Neto, Antonio M. Izar, Maria Cristina O. Fonseca, Francisco Antonio Helfenstein |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Massunaga, Nayara D. França, Carolina N. Bianco, Henrique T. Ferreira, Carlos E.S. Kato, Juliana T. Póvoa, Rui M.S. Figueiredo Neto, Antonio M. Izar, Maria Cristina O. Fonseca, Francisco Antonio Helfenstein |
dc.subject.por.fl_str_mv |
Endothelial Microparticles Monocyte Microparticles Platelet Microparticles Central Blood Pressure Hydrochlorothiazide Amlodipine |
topic |
Endothelial Microparticles Monocyte Microparticles Platelet Microparticles Central Blood Pressure Hydrochlorothiazide Amlodipine |
description |
OBJECTIVES: This prospective, randomized, open-label study aimed to compare the effects of antihypertensive treatment based on amlodipine or hydrochlorothiazide on the circulating microparticles and central blood pressure values of hypertensive patients. METHODS: The effects of treatments on circulating microparticles were assessed during monotherapy and after the consecutive addition of valsartan and rosuvastatin followed by the withdrawal of rosuvastatin. Each treatment period lasted for 30 days. Central blood pressure and pulse wave velocity were measured at the end of each period. Endothelial, monocyte, and platelet circulating microparticles were determined by flow cytometry. Central blood pressure values and pulse wave velocity were recorded at the end of each treatment period. RESULTS: No differences in brachial blood pressure were observed between the treatment groups throughout the study. Although similar central blood pressure values were observed during monotherapy, lower systolic and diastolic central blood pressure values and early and late blood pressure peaks were observed in the amlodipine arm after the addition of valsartan alone or combined with rosuvastatin. Hydrochlorothiazide-based therapy was associated with a lower number of endothelial microparticles throughout the study, whereas a higher number of platelet microparticles was observed after rosuvastatin withdrawal in the amlodipine arm. CONCLUSIONS: Despite similar brachial blood pressure values between groups throughout the study, exposure to amlodipine was associated with lower central blood pressure values after combination with valsartan, indicating a beneficial interaction. Differences between circulating microparticles were modest and were mainly influenced by rosuvastatin withdrawal in the amlodipine arm. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-18 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/164160 10.6061/clinics/2019/e1234 |
url |
https://www.revistas.usp.br/clinics/article/view/164160 |
identifier_str_mv |
10.6061/clinics/2019/e1234 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/164160/157552 https://www.revistas.usp.br/clinics/article/view/164160/157553 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 74 (2019); e1234 Clinics; v. 74 (2019); e1234 Clinics; Vol. 74 (2019); e1234 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222764650463232 |