Antibody response following Hepatitis B vaccination in peritoneal dialysis patients: does normalized urea clearance matter?

Detalhes bibliográficos
Autor(a) principal: Dervisoglu, Erkan
Data de Publicação: 2011
Outros Autores: Simsek, Melih, Yilmaz, Ahmet
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/19423
Resumo: OBJECTIVES: Data on the factors that contribute to the antibody response to hepatitis B virus vaccination in peritoneal dialysis patients are scarce. The current study was conducted on a group of peritoneal dialysis patients to learn how the response to hepatitis B virus vaccination varies according to the patient's clearance of urea normalized to total body water (Kt/V). METHODS: A convenience sample of 33 peritoneal dialysis patients (13 women and 20 men, with a mean age of 49¡12 years) was administered double doses (20 &#956;g IM in each deltoid muscle) of recombinant hepatitis B vaccine at 0, 1, 2, and 6 months. Response to immunization was measured at one to three months after the final dose of vaccine. The subjects were divided into groups according to the level of antibodies to hepatitis B surface antigen (anti-HBs), including non-responders ( < 10 IU/L), weak responders (10-100 IU/L), and good responders ( &gt; 100 IU/L). RESULTS: Among non-responders, weak responders, and good responders, significant differences were found in age (54 ± 12 vs. 56 ± 9 vs. 45¡12 years, respectively; p = 0.049) and recombinant human erythropoietin use (20 vs. 29 vs. 76%, respectively; p = 0.016). No significant differences in weekly total Kt/V (p = 0.704), weekly peritoneal Kt/V (p = 0.064) and residual glomerular filtration rate (p = 0.355) were found across the three groups. CONCLUSIONS: Delivered clearance measured by weekly peritoneal Kt/V and total clearance measured by weekly total Kt/V did not predict the response to hepatitis B virus vaccination in patients on peritoneal dialysis.
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spelling Antibody response following Hepatitis B vaccination in peritoneal dialysis patients: does normalized urea clearance matter? Continuous ambulatory peritoneal dialysisHepatitis B virusVaccinationDialysis adequacyKt/V OBJECTIVES: Data on the factors that contribute to the antibody response to hepatitis B virus vaccination in peritoneal dialysis patients are scarce. The current study was conducted on a group of peritoneal dialysis patients to learn how the response to hepatitis B virus vaccination varies according to the patient's clearance of urea normalized to total body water (Kt/V). METHODS: A convenience sample of 33 peritoneal dialysis patients (13 women and 20 men, with a mean age of 49¡12 years) was administered double doses (20 &#956;g IM in each deltoid muscle) of recombinant hepatitis B vaccine at 0, 1, 2, and 6 months. Response to immunization was measured at one to three months after the final dose of vaccine. The subjects were divided into groups according to the level of antibodies to hepatitis B surface antigen (anti-HBs), including non-responders ( < 10 IU/L), weak responders (10-100 IU/L), and good responders ( &gt; 100 IU/L). RESULTS: Among non-responders, weak responders, and good responders, significant differences were found in age (54 ± 12 vs. 56 ± 9 vs. 45¡12 years, respectively; p = 0.049) and recombinant human erythropoietin use (20 vs. 29 vs. 76%, respectively; p = 0.016). No significant differences in weekly total Kt/V (p = 0.704), weekly peritoneal Kt/V (p = 0.064) and residual glomerular filtration rate (p = 0.355) were found across the three groups. CONCLUSIONS: Delivered clearance measured by weekly peritoneal Kt/V and total clearance measured by weekly total Kt/V did not predict the response to hepatitis B virus vaccination in patients on peritoneal dialysis. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1942310.1590/S1807-59322011000900009Clinics; Vol. 66 No. 9 (2011); 1559-1562 Clinics; v. 66 n. 9 (2011); 1559-1562 Clinics; Vol. 66 Núm. 9 (2011); 1559-1562 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19423/21486Dervisoglu, ErkanSimsek, MelihYilmaz, Ahmetinfo:eu-repo/semantics/openAccess2012-05-23T16:40:04Zoai:revistas.usp.br:article/19423Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:40:04Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Antibody response following Hepatitis B vaccination in peritoneal dialysis patients: does normalized urea clearance matter?
title Antibody response following Hepatitis B vaccination in peritoneal dialysis patients: does normalized urea clearance matter?
spellingShingle Antibody response following Hepatitis B vaccination in peritoneal dialysis patients: does normalized urea clearance matter?
Dervisoglu, Erkan
Continuous ambulatory peritoneal dialysis
Hepatitis B virus
Vaccination
Dialysis adequacy
Kt/V
title_short Antibody response following Hepatitis B vaccination in peritoneal dialysis patients: does normalized urea clearance matter?
title_full Antibody response following Hepatitis B vaccination in peritoneal dialysis patients: does normalized urea clearance matter?
title_fullStr Antibody response following Hepatitis B vaccination in peritoneal dialysis patients: does normalized urea clearance matter?
title_full_unstemmed Antibody response following Hepatitis B vaccination in peritoneal dialysis patients: does normalized urea clearance matter?
title_sort Antibody response following Hepatitis B vaccination in peritoneal dialysis patients: does normalized urea clearance matter?
author Dervisoglu, Erkan
author_facet Dervisoglu, Erkan
Simsek, Melih
Yilmaz, Ahmet
author_role author
author2 Simsek, Melih
Yilmaz, Ahmet
author2_role author
author
dc.contributor.author.fl_str_mv Dervisoglu, Erkan
Simsek, Melih
Yilmaz, Ahmet
dc.subject.por.fl_str_mv Continuous ambulatory peritoneal dialysis
Hepatitis B virus
Vaccination
Dialysis adequacy
Kt/V
topic Continuous ambulatory peritoneal dialysis
Hepatitis B virus
Vaccination
Dialysis adequacy
Kt/V
description OBJECTIVES: Data on the factors that contribute to the antibody response to hepatitis B virus vaccination in peritoneal dialysis patients are scarce. The current study was conducted on a group of peritoneal dialysis patients to learn how the response to hepatitis B virus vaccination varies according to the patient's clearance of urea normalized to total body water (Kt/V). METHODS: A convenience sample of 33 peritoneal dialysis patients (13 women and 20 men, with a mean age of 49¡12 years) was administered double doses (20 &#956;g IM in each deltoid muscle) of recombinant hepatitis B vaccine at 0, 1, 2, and 6 months. Response to immunization was measured at one to three months after the final dose of vaccine. The subjects were divided into groups according to the level of antibodies to hepatitis B surface antigen (anti-HBs), including non-responders ( < 10 IU/L), weak responders (10-100 IU/L), and good responders ( &gt; 100 IU/L). RESULTS: Among non-responders, weak responders, and good responders, significant differences were found in age (54 ± 12 vs. 56 ± 9 vs. 45¡12 years, respectively; p = 0.049) and recombinant human erythropoietin use (20 vs. 29 vs. 76%, respectively; p = 0.016). No significant differences in weekly total Kt/V (p = 0.704), weekly peritoneal Kt/V (p = 0.064) and residual glomerular filtration rate (p = 0.355) were found across the three groups. CONCLUSIONS: Delivered clearance measured by weekly peritoneal Kt/V and total clearance measured by weekly total Kt/V did not predict the response to hepatitis B virus vaccination in patients on peritoneal dialysis.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19423
10.1590/S1807-59322011000900009
url https://www.revistas.usp.br/clinics/article/view/19423
identifier_str_mv 10.1590/S1807-59322011000900009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19423/21486
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 66 No. 9 (2011); 1559-1562
Clinics; v. 66 n. 9 (2011); 1559-1562
Clinics; Vol. 66 Núm. 9 (2011); 1559-1562
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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