Red blood cell distribution width is associated with myocardial injury in non-ST-elevation acute coronary syndrome

Detalhes bibliográficos
Autor(a) principal: Tenekecioglu, Erhan
Data de Publicação: 2015
Outros Autores: Yilmaz, Mustafa, Yontar, Osman Can, Bekler, Adem, Peker, Tezcan, Karaagac, Kemal, Ozluk, Ozlem Arican, Agca, Fahriye Vatansever, Kuzeytemiz, Mustafa, Senturk, Muhammed, Aslan, Burhan, Topal, Dursun
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/96936
Resumo: OBJECTIVES: The red blood cell distribution width has been associated with an increased risk of cardiovascular events. In the present study, we assessed the relationship between red cell distribution width values and cardiac troponin I levels in patients admitted with non-ST-elevation acute coronary syndrome. METHODS: We analyzed blood parameters in 251 adult patients who were consecutively admitted to the intensive coronary care unit with non-ST-elevation acute coronary syndrome over a 1-year period. For all patients, a baseline blood sample was collected for routine hematological testing. Cardiac troponin I was measured at baseline and after 6 h. The patients were diagnosed with non-ST-elevation myocardial infarction or unstable angina based on the elevation of cardiac troponin I levels. RESULTS: The red cell distribution width was higher in the group with non-ST-elevation myocardial infarction compared with the patient group with unstable angina (14.6±1.0 vs 13.06±1.7, respectively; p = 0.006). Coronary thrombus was detected more frequently in the group of patients with non-ST-elevation myocardial infarction than in the patients with unstable angina (72% vs 51%, respectively; p = 0.007). Using receiver operating characteristic curve analysis for the prediction of non-ST-elevation myocardial infarction based on the red cell distribution width, the area under the curve was 0.649 (95% confidence interval: 0.546-0.753; p = 0.006), suggesting a modest model for the prediction of non-ST-elevation myocardial infarction using the red cell distribution width. At a cut-off value of 14%, the sensitivity and specificity of the red cell distribution width were 73% and 59%, respectively. Additionally, the red cell distribution width was positively correlated with cardiac troponin I (r = 0.19; p = 0.006). CONCLUSION: A greater baseline red cell distribution width value was associated with myocardial injury and elevated cardiac troponin I levels in non-ST-elevation acute coronary syndrome. Therefore, the red cell distribution width could be considered for risk stratification of acute coronary syndrome patients admitted to emergency departments.
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spelling Red blood cell distribution width is associated with myocardial injury in non-ST-elevation acute coronary syndrome OBJECTIVES: The red blood cell distribution width has been associated with an increased risk of cardiovascular events. In the present study, we assessed the relationship between red cell distribution width values and cardiac troponin I levels in patients admitted with non-ST-elevation acute coronary syndrome. METHODS: We analyzed blood parameters in 251 adult patients who were consecutively admitted to the intensive coronary care unit with non-ST-elevation acute coronary syndrome over a 1-year period. For all patients, a baseline blood sample was collected for routine hematological testing. Cardiac troponin I was measured at baseline and after 6 h. The patients were diagnosed with non-ST-elevation myocardial infarction or unstable angina based on the elevation of cardiac troponin I levels. RESULTS: The red cell distribution width was higher in the group with non-ST-elevation myocardial infarction compared with the patient group with unstable angina (14.6±1.0 vs 13.06±1.7, respectively; p = 0.006). Coronary thrombus was detected more frequently in the group of patients with non-ST-elevation myocardial infarction than in the patients with unstable angina (72% vs 51%, respectively; p = 0.007). Using receiver operating characteristic curve analysis for the prediction of non-ST-elevation myocardial infarction based on the red cell distribution width, the area under the curve was 0.649 (95% confidence interval: 0.546-0.753; p = 0.006), suggesting a modest model for the prediction of non-ST-elevation myocardial infarction using the red cell distribution width. At a cut-off value of 14%, the sensitivity and specificity of the red cell distribution width were 73% and 59%, respectively. Additionally, the red cell distribution width was positively correlated with cardiac troponin I (r = 0.19; p = 0.006). CONCLUSION: A greater baseline red cell distribution width value was associated with myocardial injury and elevated cardiac troponin I levels in non-ST-elevation acute coronary syndrome. Therefore, the red cell distribution width could be considered for risk stratification of acute coronary syndrome patients admitted to emergency departments. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/9693610.6061/clinics/2015(01)04Clinics; Vol. 70 No. 1 (2015); 18-23Clinics; v. 70 n. 1 (2015); 18-23Clinics; Vol. 70 Núm. 1 (2015); 18-231980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/96936/96016Copyright (c) 2015 Clinicsinfo:eu-repo/semantics/openAccessTenekecioglu, Erhan Yilmaz, Mustafa Yontar, Osman Can Bekler, Adem Peker, Tezcan Karaagac, Kemal Ozluk, Ozlem Arican Agca, Fahriye Vatansever Kuzeytemiz, Mustafa Senturk, Muhammed Aslan, Burhan Topal, Dursun 2015-03-27T19:04:38Zoai:revistas.usp.br:article/96936Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2015-03-27T19:04:38Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Red blood cell distribution width is associated with myocardial injury in non-ST-elevation acute coronary syndrome
title Red blood cell distribution width is associated with myocardial injury in non-ST-elevation acute coronary syndrome
spellingShingle Red blood cell distribution width is associated with myocardial injury in non-ST-elevation acute coronary syndrome
Tenekecioglu, Erhan
title_short Red blood cell distribution width is associated with myocardial injury in non-ST-elevation acute coronary syndrome
title_full Red blood cell distribution width is associated with myocardial injury in non-ST-elevation acute coronary syndrome
title_fullStr Red blood cell distribution width is associated with myocardial injury in non-ST-elevation acute coronary syndrome
title_full_unstemmed Red blood cell distribution width is associated with myocardial injury in non-ST-elevation acute coronary syndrome
title_sort Red blood cell distribution width is associated with myocardial injury in non-ST-elevation acute coronary syndrome
author Tenekecioglu, Erhan
author_facet Tenekecioglu, Erhan
Yilmaz, Mustafa
Yontar, Osman Can
Bekler, Adem
Peker, Tezcan
Karaagac, Kemal
Ozluk, Ozlem Arican
Agca, Fahriye Vatansever
Kuzeytemiz, Mustafa
Senturk, Muhammed
Aslan, Burhan
Topal, Dursun
author_role author
author2 Yilmaz, Mustafa
Yontar, Osman Can
Bekler, Adem
Peker, Tezcan
Karaagac, Kemal
Ozluk, Ozlem Arican
Agca, Fahriye Vatansever
Kuzeytemiz, Mustafa
Senturk, Muhammed
Aslan, Burhan
Topal, Dursun
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tenekecioglu, Erhan
Yilmaz, Mustafa
Yontar, Osman Can
Bekler, Adem
Peker, Tezcan
Karaagac, Kemal
Ozluk, Ozlem Arican
Agca, Fahriye Vatansever
Kuzeytemiz, Mustafa
Senturk, Muhammed
Aslan, Burhan
Topal, Dursun
description OBJECTIVES: The red blood cell distribution width has been associated with an increased risk of cardiovascular events. In the present study, we assessed the relationship between red cell distribution width values and cardiac troponin I levels in patients admitted with non-ST-elevation acute coronary syndrome. METHODS: We analyzed blood parameters in 251 adult patients who were consecutively admitted to the intensive coronary care unit with non-ST-elevation acute coronary syndrome over a 1-year period. For all patients, a baseline blood sample was collected for routine hematological testing. Cardiac troponin I was measured at baseline and after 6 h. The patients were diagnosed with non-ST-elevation myocardial infarction or unstable angina based on the elevation of cardiac troponin I levels. RESULTS: The red cell distribution width was higher in the group with non-ST-elevation myocardial infarction compared with the patient group with unstable angina (14.6±1.0 vs 13.06±1.7, respectively; p = 0.006). Coronary thrombus was detected more frequently in the group of patients with non-ST-elevation myocardial infarction than in the patients with unstable angina (72% vs 51%, respectively; p = 0.007). Using receiver operating characteristic curve analysis for the prediction of non-ST-elevation myocardial infarction based on the red cell distribution width, the area under the curve was 0.649 (95% confidence interval: 0.546-0.753; p = 0.006), suggesting a modest model for the prediction of non-ST-elevation myocardial infarction using the red cell distribution width. At a cut-off value of 14%, the sensitivity and specificity of the red cell distribution width were 73% and 59%, respectively. Additionally, the red cell distribution width was positively correlated with cardiac troponin I (r = 0.19; p = 0.006). CONCLUSION: A greater baseline red cell distribution width value was associated with myocardial injury and elevated cardiac troponin I levels in non-ST-elevation acute coronary syndrome. Therefore, the red cell distribution width could be considered for risk stratification of acute coronary syndrome patients admitted to emergency departments.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/96936
10.6061/clinics/2015(01)04
url https://www.revistas.usp.br/clinics/article/view/96936
identifier_str_mv 10.6061/clinics/2015(01)04
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/96936/96016
dc.rights.driver.fl_str_mv Copyright (c) 2015 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2015 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 70 No. 1 (2015); 18-23
Clinics; v. 70 n. 1 (2015); 18-23
Clinics; Vol. 70 Núm. 1 (2015); 18-23
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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