Evaluation of histological changes after tracheal occlusion at different gestational ages in a fetal rat model

Detalhes bibliográficos
Autor(a) principal: Gallindo, Rodrigo Melo
Data de Publicação: 2013
Outros Autores: Gonçalves, Frances Lilian Lanhellas, Barreto, Carolina Teixeira de Resende, Schmidt, Augusto Frederico Santos, Pereira, Luis Antonio Violin Dias, Sbragia, Lourenço
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/52317
Resumo: OBJECTIVES: To evaluate the histological changes of tracheal cartilage and epithelium caused by tracheal occlusion at different gestational ages in a fetal rat model. METHODS: Rat fetuses were divided into two groups: a) External control, composed of non-operated rats, and b) Interventional group, composed of rats operated upon on gestational day 18.5 (term = 22 days), divided into triads: 1) Tracheal occlusion, 2) Internal control and 3) Sham (manipulated but not operated). Morphological data for body weight, total lung weight and total lung weight/body weight ratio were collected and measured on gestational days 19.5, 20.5 and 21.5. Tracheal samples were histologically processed, and epithelial, chondral and total tracheal thicknesses were measured on each gestational day. RESULTS: The tracheal occlusion group exhibited an increase in total lung weight/body weight ratio (p
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spelling Evaluation of histological changes after tracheal occlusion at different gestational ages in a fetal rat model Therapeutic OcclusionTracheaHerniaDiaphragmaticRatsExperimental Model OBJECTIVES: To evaluate the histological changes of tracheal cartilage and epithelium caused by tracheal occlusion at different gestational ages in a fetal rat model. METHODS: Rat fetuses were divided into two groups: a) External control, composed of non-operated rats, and b) Interventional group, composed of rats operated upon on gestational day 18.5 (term = 22 days), divided into triads: 1) Tracheal occlusion, 2) Internal control and 3) Sham (manipulated but not operated). Morphological data for body weight, total lung weight and total lung weight/body weight ratio were collected and measured on gestational days 19.5, 20.5 and 21.5. Tracheal samples were histologically processed, and epithelial, chondral and total tracheal thicknesses were measured on each gestational day. RESULTS: The tracheal occlusion group exhibited an increase in total lung weight/body weight ratio (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/5231710.6061/clinics/2013(01)OA09Clinics; Vol. 68 No. 1 (2013); 59-63 Clinics; v. 68 n. 1 (2013); 59-63 Clinics; Vol. 68 Núm. 1 (2013); 59-63 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/52317/56344Gallindo, Rodrigo MeloGonçalves, Frances Lilian LanhellasBarreto, Carolina Teixeira de ResendeSchmidt, Augusto Frederico SantosPereira, Luis Antonio Violin DiasSbragia, Lourençoinfo:eu-repo/semantics/openAccess2013-03-09T14:08:18Zoai:revistas.usp.br:article/52317Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2013-03-09T14:08:18Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Evaluation of histological changes after tracheal occlusion at different gestational ages in a fetal rat model
title Evaluation of histological changes after tracheal occlusion at different gestational ages in a fetal rat model
spellingShingle Evaluation of histological changes after tracheal occlusion at different gestational ages in a fetal rat model
Gallindo, Rodrigo Melo
Therapeutic Occlusion
Trachea
Hernia
Diaphragmatic
Rats
Experimental Model
title_short Evaluation of histological changes after tracheal occlusion at different gestational ages in a fetal rat model
title_full Evaluation of histological changes after tracheal occlusion at different gestational ages in a fetal rat model
title_fullStr Evaluation of histological changes after tracheal occlusion at different gestational ages in a fetal rat model
title_full_unstemmed Evaluation of histological changes after tracheal occlusion at different gestational ages in a fetal rat model
title_sort Evaluation of histological changes after tracheal occlusion at different gestational ages in a fetal rat model
author Gallindo, Rodrigo Melo
author_facet Gallindo, Rodrigo Melo
Gonçalves, Frances Lilian Lanhellas
Barreto, Carolina Teixeira de Resende
Schmidt, Augusto Frederico Santos
Pereira, Luis Antonio Violin Dias
Sbragia, Lourenço
author_role author
author2 Gonçalves, Frances Lilian Lanhellas
Barreto, Carolina Teixeira de Resende
Schmidt, Augusto Frederico Santos
Pereira, Luis Antonio Violin Dias
Sbragia, Lourenço
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Gallindo, Rodrigo Melo
Gonçalves, Frances Lilian Lanhellas
Barreto, Carolina Teixeira de Resende
Schmidt, Augusto Frederico Santos
Pereira, Luis Antonio Violin Dias
Sbragia, Lourenço
dc.subject.por.fl_str_mv Therapeutic Occlusion
Trachea
Hernia
Diaphragmatic
Rats
Experimental Model
topic Therapeutic Occlusion
Trachea
Hernia
Diaphragmatic
Rats
Experimental Model
description OBJECTIVES: To evaluate the histological changes of tracheal cartilage and epithelium caused by tracheal occlusion at different gestational ages in a fetal rat model. METHODS: Rat fetuses were divided into two groups: a) External control, composed of non-operated rats, and b) Interventional group, composed of rats operated upon on gestational day 18.5 (term = 22 days), divided into triads: 1) Tracheal occlusion, 2) Internal control and 3) Sham (manipulated but not operated). Morphological data for body weight, total lung weight and total lung weight/body weight ratio were collected and measured on gestational days 19.5, 20.5 and 21.5. Tracheal samples were histologically processed, and epithelial, chondral and total tracheal thicknesses were measured on each gestational day. RESULTS: The tracheal occlusion group exhibited an increase in total lung weight/body weight ratio (p
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/52317
10.6061/clinics/2013(01)OA09
url https://www.revistas.usp.br/clinics/article/view/52317
identifier_str_mv 10.6061/clinics/2013(01)OA09
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/52317/56344
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 68 No. 1 (2013); 59-63
Clinics; v. 68 n. 1 (2013); 59-63
Clinics; Vol. 68 Núm. 1 (2013); 59-63
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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