The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/18482 |
Resumo: | OBJECTIVE: This study aimed to determine the frequency of the PROGINS polymorphism in women with endometriosis-associated infertility, in infertile women without endometriosis and in controls. INTRODUCTION: The human progesterone receptor gene has two isoforms that modulate the biological action of progesterone: isoform A, which is capable of inhibiting the activation of the estrogen receptors, and isoform B, which has the capacity to activate the estrogen receptors. Several polymorphisms have been described for this gene, among which one stands out: a polymorphism named PROGINS, which has been speculated to be related to the genesis of endometriosis by several studies with conflicting results. METHODS: This was a prospective study that included 148 patients with endometriosis-associated infertility, 50 idiopathic infertile patients and 179 fertile women as controls. The PROGINS polymorphism was studied by PCR. RESULTS: Genotypes P1P1, P1P2 and P2P2 (P2 representing the PROGINS polymorphism) of the progesterone receptor gene presented frequencies of 93.9%, 5.4% and 0.7%, respectively, in the women with endometriosis-associated infertility (p=0.2101, OR=0.51, 95% CI=0.24-1.09); 94.4%, 4.2% and 1.4%, respectively, in the patients with minimal/mild endometriosis (p=0.2725, OR=0.53, 95% CI=0.20-1.43); 93.5%, 6.5% and 0%, respectively, among the patients with moderate/severe endometriosis (p=0.3679, OR=0.49, 95% CI=0.18-1.31); 86.0%, 14.0% and 0%, respectively, in idiopathic infertile women (p=0.8146, OR=1.10, 95% CI=0.46-2.63); and 88.3%, 10.6% and 1.1%, respectively, in the control group. CONCLUSION: The data suggest that PROGINS is not related either to endometriosis-associated infertility or to idiopathic infertility in the population studied. |
id |
USP-19_93958bbc37b0d9c9e54d9fe1f7c73d62 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/18482 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility endometriosispolymorphismPROGINSprogesterone receptor geneinfertility OBJECTIVE: This study aimed to determine the frequency of the PROGINS polymorphism in women with endometriosis-associated infertility, in infertile women without endometriosis and in controls. INTRODUCTION: The human progesterone receptor gene has two isoforms that modulate the biological action of progesterone: isoform A, which is capable of inhibiting the activation of the estrogen receptors, and isoform B, which has the capacity to activate the estrogen receptors. Several polymorphisms have been described for this gene, among which one stands out: a polymorphism named PROGINS, which has been speculated to be related to the genesis of endometriosis by several studies with conflicting results. METHODS: This was a prospective study that included 148 patients with endometriosis-associated infertility, 50 idiopathic infertile patients and 179 fertile women as controls. The PROGINS polymorphism was studied by PCR. RESULTS: Genotypes P1P1, P1P2 and P2P2 (P2 representing the PROGINS polymorphism) of the progesterone receptor gene presented frequencies of 93.9%, 5.4% and 0.7%, respectively, in the women with endometriosis-associated infertility (p=0.2101, OR=0.51, 95% CI=0.24-1.09); 94.4%, 4.2% and 1.4%, respectively, in the patients with minimal/mild endometriosis (p=0.2725, OR=0.53, 95% CI=0.20-1.43); 93.5%, 6.5% and 0%, respectively, among the patients with moderate/severe endometriosis (p=0.3679, OR=0.49, 95% CI=0.18-1.31); 86.0%, 14.0% and 0%, respectively, in idiopathic infertile women (p=0.8146, OR=1.10, 95% CI=0.46-2.63); and 88.3%, 10.6% and 1.1%, respectively, in the control group. CONCLUSION: The data suggest that PROGINS is not related either to endometriosis-associated infertility or to idiopathic infertility in the population studied. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1848210.1590/S1807-59322010001100002Clinics; Vol. 65 No. 11 (2010); 1073-1076 Clinics; v. 65 n. 11 (2010); 1073-1076 Clinics; Vol. 65 Núm. 11 (2010); 1073-1076 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18482/20545Gimenes, CristianeBianco, BiancaMafra, Fernanda AbaniRosset, VictorChristofolini, Denise MariaBarbosa, Caio Parenteinfo:eu-repo/semantics/openAccess2012-05-23T11:26:38Zoai:revistas.usp.br:article/18482Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:26:38Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility |
title |
The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility |
spellingShingle |
The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility Gimenes, Cristiane endometriosis polymorphism PROGINS progesterone receptor gene infertility |
title_short |
The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility |
title_full |
The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility |
title_fullStr |
The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility |
title_full_unstemmed |
The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility |
title_sort |
The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility |
author |
Gimenes, Cristiane |
author_facet |
Gimenes, Cristiane Bianco, Bianca Mafra, Fernanda Abani Rosset, Victor Christofolini, Denise Maria Barbosa, Caio Parente |
author_role |
author |
author2 |
Bianco, Bianca Mafra, Fernanda Abani Rosset, Victor Christofolini, Denise Maria Barbosa, Caio Parente |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gimenes, Cristiane Bianco, Bianca Mafra, Fernanda Abani Rosset, Victor Christofolini, Denise Maria Barbosa, Caio Parente |
dc.subject.por.fl_str_mv |
endometriosis polymorphism PROGINS progesterone receptor gene infertility |
topic |
endometriosis polymorphism PROGINS progesterone receptor gene infertility |
description |
OBJECTIVE: This study aimed to determine the frequency of the PROGINS polymorphism in women with endometriosis-associated infertility, in infertile women without endometriosis and in controls. INTRODUCTION: The human progesterone receptor gene has two isoforms that modulate the biological action of progesterone: isoform A, which is capable of inhibiting the activation of the estrogen receptors, and isoform B, which has the capacity to activate the estrogen receptors. Several polymorphisms have been described for this gene, among which one stands out: a polymorphism named PROGINS, which has been speculated to be related to the genesis of endometriosis by several studies with conflicting results. METHODS: This was a prospective study that included 148 patients with endometriosis-associated infertility, 50 idiopathic infertile patients and 179 fertile women as controls. The PROGINS polymorphism was studied by PCR. RESULTS: Genotypes P1P1, P1P2 and P2P2 (P2 representing the PROGINS polymorphism) of the progesterone receptor gene presented frequencies of 93.9%, 5.4% and 0.7%, respectively, in the women with endometriosis-associated infertility (p=0.2101, OR=0.51, 95% CI=0.24-1.09); 94.4%, 4.2% and 1.4%, respectively, in the patients with minimal/mild endometriosis (p=0.2725, OR=0.53, 95% CI=0.20-1.43); 93.5%, 6.5% and 0%, respectively, among the patients with moderate/severe endometriosis (p=0.3679, OR=0.49, 95% CI=0.18-1.31); 86.0%, 14.0% and 0%, respectively, in idiopathic infertile women (p=0.8146, OR=1.10, 95% CI=0.46-2.63); and 88.3%, 10.6% and 1.1%, respectively, in the control group. CONCLUSION: The data suggest that PROGINS is not related either to endometriosis-associated infertility or to idiopathic infertility in the population studied. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18482 10.1590/S1807-59322010001100002 |
url |
https://www.revistas.usp.br/clinics/article/view/18482 |
identifier_str_mv |
10.1590/S1807-59322010001100002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18482/20545 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 65 No. 11 (2010); 1073-1076 Clinics; v. 65 n. 11 (2010); 1073-1076 Clinics; Vol. 65 Núm. 11 (2010); 1073-1076 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222755652632576 |