An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/83755 |
Resumo: | OBJECTIVES: Our study aimed to investigate the impact of fatigue on the severity of stroke and to explore the underlying mechanisms. METHODS: Fatigued male rats underwent middle cerebral artery occlusion and the infarcted brain area was determined. Then, coagulation parameters were assessed in the fatigued group and a control group. In addition, the level of fibrinogen was determined in rats deprived of sleep for various numbers of days. To study whether interleukin-6 was involved in fibrinogen synthesis during fatigue, we also measured levels of interleukin-6 in rats deprived of sleep for various numbers of days. Furthermore, brain injury by middle cerebral artery occlusion was measured in wild-type mice, interleukin-6-/- mice and wild-type mice treated with bezafibrate. RESULTS: More severe cerebral infarction was observed in the fatigued rats, resulting in an infarct ratio of 23.4%. The infarct ratio was significantly increased in the fatigued rats compared with that in the control group (8%, p |
id |
USP-19_9f3c8d4b66f1262545e3f179b4b5894c |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/83755 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis OBJECTIVES: Our study aimed to investigate the impact of fatigue on the severity of stroke and to explore the underlying mechanisms. METHODS: Fatigued male rats underwent middle cerebral artery occlusion and the infarcted brain area was determined. Then, coagulation parameters were assessed in the fatigued group and a control group. In addition, the level of fibrinogen was determined in rats deprived of sleep for various numbers of days. To study whether interleukin-6 was involved in fibrinogen synthesis during fatigue, we also measured levels of interleukin-6 in rats deprived of sleep for various numbers of days. Furthermore, brain injury by middle cerebral artery occlusion was measured in wild-type mice, interleukin-6-/- mice and wild-type mice treated with bezafibrate. RESULTS: More severe cerebral infarction was observed in the fatigued rats, resulting in an infarct ratio of 23.4%. The infarct ratio was significantly increased in the fatigued rats compared with that in the control group (8%, pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/8375510.6061/clinics/2014(06)10Clinics; Vol. 69 No. 6 (2014); 426-432Clinics; v. 69 n. 6 (2014); 426-432Clinics; Vol. 69 Núm. 6 (2014); 426-4321980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/83755/86659Lei, Hong Xu, Jian Cheng, Li-Juan Guo, Qi Deng, An-Mei Li, Yong-Shen info:eu-repo/semantics/openAccess2014-08-12T22:31:56Zoai:revistas.usp.br:article/83755Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2014-08-12T22:31:56Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis |
title |
An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis |
spellingShingle |
An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis Lei, Hong |
title_short |
An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis |
title_full |
An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis |
title_fullStr |
An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis |
title_full_unstemmed |
An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis |
title_sort |
An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis |
author |
Lei, Hong |
author_facet |
Lei, Hong Xu, Jian Cheng, Li-Juan Guo, Qi Deng, An-Mei Li, Yong-Shen |
author_role |
author |
author2 |
Xu, Jian Cheng, Li-Juan Guo, Qi Deng, An-Mei Li, Yong-Shen |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Lei, Hong Xu, Jian Cheng, Li-Juan Guo, Qi Deng, An-Mei Li, Yong-Shen |
description |
OBJECTIVES: Our study aimed to investigate the impact of fatigue on the severity of stroke and to explore the underlying mechanisms. METHODS: Fatigued male rats underwent middle cerebral artery occlusion and the infarcted brain area was determined. Then, coagulation parameters were assessed in the fatigued group and a control group. In addition, the level of fibrinogen was determined in rats deprived of sleep for various numbers of days. To study whether interleukin-6 was involved in fibrinogen synthesis during fatigue, we also measured levels of interleukin-6 in rats deprived of sleep for various numbers of days. Furthermore, brain injury by middle cerebral artery occlusion was measured in wild-type mice, interleukin-6-/- mice and wild-type mice treated with bezafibrate. RESULTS: More severe cerebral infarction was observed in the fatigued rats, resulting in an infarct ratio of 23.4%. The infarct ratio was significantly increased in the fatigued rats compared with that in the control group (8%, p |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/83755 10.6061/clinics/2014(06)10 |
url |
https://www.revistas.usp.br/clinics/article/view/83755 |
identifier_str_mv |
10.6061/clinics/2014(06)10 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/83755/86659 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 69 No. 6 (2014); 426-432 Clinics; v. 69 n. 6 (2014); 426-432 Clinics; Vol. 69 Núm. 6 (2014); 426-432 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222761215328256 |